Zinc lysine pharmaceutical composition including chiral isomeric compound and use thereof

Abstract

The present invention provides a zinc lisine composition containing a chiral isomer compound and a preparation method thereof for the prevention or treatment of growth retardation, malnutrition, etc. caused by zinc and lysine deficiency in humans or mammals, and as health food and medicine In clinical application, the obtained product has a new adaptation group or better pertinence or clinical safety in clinical use.

Description

technical field

[0001] The invention relates to the field of medical technology, in particular to provide zinc lysine or zinc lysine for the prevention or treatment of growth retardation and malnutrition caused by zinc and lysine deficiency in humans or mammals Or the pharmaceutical composition of zinc lysine gluconate and its preparation method and application. Background technique

[0002] Lysine is a basic amino acid and has three basic forms: DL-lysine, D-lysine and L-lysine. L-lysine is one of the eight essential amino acids for the human body. L-lysine Provides structural components for the synthesis of carnitine, which drives the synthesis of fatty acids in cells. Especially in the period of child development, recovery after illness, pregnancy and lactation, etc., the demand for L-lysine is higher. Due to its low content in foods such as rice and corn, it is easy to cause deficiency in the human body, and it is called "the first amino acid deficiency".

[0003] L-l...

Examples

Embodiment 1

[0048] Example 1 Preparation of L-Lysine Hydrochloride Zinc Gluconate Capsules (Specification: L-Lysine Hydrochloride 125mg / Zinc Gluconate 35mg / granule, calculated as L-Lysine Hydrochloride and Zinc Gluconate Anhydrous ) Prescription: 125g of L-lysine hydrochloride, 35g of zinc gluconate trihydrate (weight converted to zinc gluconate anhydrate);

[0049] Preparation process: Take the prescription amount of L-lysine hydrochloride and zinc gluconate trihydrate after crushing and passing through 60-80 mesh sieves, mix evenly, measure the content of the main drug in the granules, fill capsules, pack, and inspect , get products.

Embodiment 2

[0050] Example 2 The preparation of L-lysine hydrochloride zinc gluconate capsules (specification: L-lysine hydrochloride 62.5mg / zinc gluconate 17.5mg / grain, with L-lysine hydrochloride and zinc gluconate anhydrous respectively Material) Prescription: L-lysine hydrochloride 125g, zinc gluconate trihydrate (weight converted to zinc gluconate anhydrate) 35g;

[0051] Preparation process: Take L-lysine hydrochloride and zinc gluconate 3 hydrate which are pulverized and passed through a 60-80 mesh sieve, mix evenly, measure the content of the main drug in the granules, fill capsules, pack, and inspect , get products.

Embodiment 3

[0052] Example 3 Preparation of L-Lysine Hydrochloride Zinc Gluconate Capsules (specification: 112.5mg / 38.5mg / capsule, calculated as L-lysine hydrochloride and zinc gluconate anhydrous respectively) Prescription: L-lysine hydrochloride Amino acid 112.5g, zinc gluconate trihydrate (weight converted to zinc gluconate anhydrate) 38.5g, magnesium stearate 0.5g;

[0053] Preparation process: Take L-lysine hydrochloride, zinc gluconate trihydrate, and magnesium stearate in the prescribed amount after crushing and passing through a 60-100 mesh sieve, mix evenly, measure the content of the main drug in the granules, and fill Capsules, packaging, testing, and finished products.

technical field

[0001] The invention relates to the field of medical technology, in particular to provide zinc lysine or zinc lysine for the prevention or treatment of growth retardation and malnutrition caused by zinc and lysine deficiency in humans or mammals Or the pharmaceutical composition of zinc lysine gluconate and its preparation method and application. Background technique

[0002] Lysine is a basic amino acid and has three basic forms: DL-lysine, D-lysine and L-lysine. L-lysine is one of the eight essential amino acids for the human body. L-lysine Provides structural components for the synthesis of carnitine, which drives the synthesis of fatty acids in cells. Especially in the period of child development, recovery after illness, pregnancy and lactation, etc., the demand for L-lysine is higher. Due to its low content in foods such as rice and corn, it is easy to cause deficiency in the human body, and it is called "the first amino acid deficiency".

[0003] L-l...

Examples

Embodiment 1

[0048] Example 1 Preparation of L-Lysine Hydrochloride Zinc Gluconate Capsules (Specification: L-Lysine Hydrochloride 125mg / Zinc Gluconate 35mg / granule, calculated as L-Lysine Hydrochloride and Zinc Gluconate Anhydrous ) Prescription: 125g of L-lysine hydrochloride, 35g of zinc gluconate trihydrate (weight converted to zinc gluconate anhydrate);

[0049] Preparation process: Take the prescription amount of L-lysine hydrochloride and zinc gluconate trihydrate after crushing and passing through 60-80 mesh sieves, mix evenly, measure the content of the main drug in the granules, fill capsules, pack, and inspect , get products.

Embodiment 2

[0050] Example 2 The preparation of L-lysine hydrochloride zinc gluconate capsules (specification: L-lysine hydrochloride 62.5mg / zinc gluconate 17.5mg / grain, with L-lysine hydrochloride and zinc gluconate anhydrous respectively Material) Prescription: L-lysine hydrochloride 125g, zinc gluconate trihydrate (weight converted to zinc gluconate anhydrate) 35g;

[0051] Preparation process: Take L-lysine hydrochloride and zinc gluconate 3 hydrate which are pulverized and passed through a 60-80 mesh sieve, mix evenly, measure the content of the main drug in the granules, fill capsules, pack, and inspect , get products.

Embodiment 3

[0052] Example 3 Preparation of L-Lysine Hydrochloride Zinc Gluconate Capsules (specification: 112.5mg / 38.5mg / capsule, calculated as L-lysine hydrochloride and zinc gluconate anhydrous respectively) Prescription: L-lysine hydrochloride Amino acid 112.5g, zinc gluconate trihydrate (weight converted to zinc gluconate anhydrate) 38.5g, magnesium stearate 0.5g;

[0053] Preparation process: Take L-lysine hydrochloride, zinc gluconate trihydrate, and magnesium stearate in the prescribed amount after crushing and passing through a 60-100 mesh sieve, mix evenly, measure the content of the main drug in the granules, and fill Capsules, packaging, testing, and finished products.

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