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Zinc lysine pharmaceutical composition including chiral isomeric compound and use thereof

A composition and hydrate technology, applied in the field of medicine, can solve the problems of waste of social resources, limitation of preparation quality or nutritional or therapeutic value, and not being fully suitable for clinical application, etc.

Active Publication Date: 2017-10-27
刘力
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Because lysine contains half of D-lysine and L-lysine, only L-lysine is easily absorbed by the body and has great utilization value for the human body. D-lysine is not easily absorbed by the body. The L-lysine hydrochloride granules of a single optical isomer that are absorbed and utilized by the human body are also publicly reported, but they are limited to single-component administration
In addition, the compound lysine zinc glucose tablets or granules in the prior art are not suitable for patients with hyperchloremia, acidosis and renal insufficiency in some cases, and the current preparations do not limit the use of L-lysine acid and zinc gluconate (C 12 h 22 o 14 Zn) composition, this makes the quality or nutritional or therapeutic value of preparation or be restricted or can not be in optimized state; Moreover, present a unit dosage specification only has the lysine hydrochloride of 125mg and the zinc gluconate tablet of 35mg or Granules, so that there are problems in the convenience of taking and the accurate dosage of children's taking, or they are not suitable for clinical application.
In the preparation when the dosage unit is doubled, half of the D-lysine that is not easily absorbed and utilized by the human body is added, so that there are also problems in the convenience of taking, transportation and packaging, or it cannot be fully suitable for clinical applications, let alone It is conducive to saving human resources and building a resource-saving society. These various unfavorable or bad situations have been ignored by professionals for many years, which actually cause waste of social resources and increase pressure on environmental protection. However, there is no breakthrough in the old framework.

Method used

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  • Zinc lysine pharmaceutical composition including chiral isomeric compound and use thereof
  • Zinc lysine pharmaceutical composition including chiral isomeric compound and use thereof
  • Zinc lysine pharmaceutical composition including chiral isomeric compound and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Example 1 Preparation of L-Lysine Hydrochloride Zinc Gluconate Capsules (Specification: L-Lysine Hydrochloride 125mg / Zinc Gluconate 35mg / granule, calculated as L-Lysine Hydrochloride and Zinc Gluconate Anhydrous ) Prescription: 125g of L-lysine hydrochloride, 35g of zinc gluconate trihydrate (weight converted to zinc gluconate anhydrate);

[0049] Preparation process: Take the prescription amount of L-lysine hydrochloride and zinc gluconate trihydrate after crushing and passing through 60-80 mesh sieves, mix evenly, measure the content of the main drug in the granules, fill capsules, pack, and inspect , get products.

Embodiment 2

[0050] Example 2 The preparation of L-lysine hydrochloride zinc gluconate capsules (specification: L-lysine hydrochloride 62.5mg / zinc gluconate 17.5mg / grain, with L-lysine hydrochloride and zinc gluconate anhydrous respectively Material) Prescription: L-lysine hydrochloride 125g, zinc gluconate trihydrate (weight converted to zinc gluconate anhydrate) 35g;

[0051] Preparation process: Take L-lysine hydrochloride and zinc gluconate 3 hydrate which are pulverized and passed through a 60-80 mesh sieve, mix evenly, measure the content of the main drug in the granules, fill capsules, pack, and inspect , get products.

Embodiment 3

[0052] Example 3 Preparation of L-Lysine Hydrochloride Zinc Gluconate Capsules (specification: 112.5mg / 38.5mg / capsule, calculated as L-lysine hydrochloride and zinc gluconate anhydrous respectively) Prescription: L-lysine hydrochloride Amino acid 112.5g, zinc gluconate trihydrate (weight converted to zinc gluconate anhydrate) 38.5g, magnesium stearate 0.5g;

[0053] Preparation process: Take L-lysine hydrochloride, zinc gluconate trihydrate, and magnesium stearate in the prescribed amount after crushing and passing through a 60-100 mesh sieve, mix evenly, measure the content of the main drug in the granules, and fill Capsules, packaging, testing, and finished products.

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Abstract

The present invention provides a zinc lisine composition containing a chiral isomer compound and a preparation method thereof for the prevention or treatment of growth retardation, malnutrition, etc. caused by zinc and lysine deficiency in humans or mammals, and as health food and medicine In clinical application, the obtained product has a new adaptation group or better pertinence or clinical safety in clinical use.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to provide zinc lysine or zinc lysine for the prevention or treatment of growth retardation and malnutrition caused by zinc and lysine deficiency in humans or mammals Or the pharmaceutical composition of zinc lysine gluconate and its preparation method and application. Background technique [0002] Lysine is a basic amino acid and has three basic forms: DL-lysine, D-lysine and L-lysine. L-lysine is one of the eight essential amino acids for the human body. L-lysine Provides structural components for the synthesis of carnitine, which drives the synthesis of fatty acids in cells. Especially in the period of child development, recovery after illness, pregnancy and lactation, etc., the demand for L-lysine is higher. Due to its low content in foods such as rice and corn, it is easy to cause deficiency in the human body, and it is called "the first amino acid deficiency". [0003] L-l...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/198A61P3/02A61P1/14A23L33/10A61K31/191
Inventor 刘力
Owner 刘力
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