Lysine and calcium hydrophosphate pharmaceutical composition comprising chiral isomeric compound and application of pharmaceutical composition

Abstract

The invention provides a pharmaceutical composition of lysine and calcium hydrophosphate or dihydrate of the calcium hydrophosphate, which comprises a chiral isomeric compound, and is used for preventing or treating L-lysine and calcium deficiency, retarded growth of children and teenagers, osteoporosis, metabolic acidosis and brain trauma, and regulating blood pressure and the like, a preparation method of the pharmaceutical composition, and an application of the pharmaceutical composition as health foods or medicines. The obtained product has new intended population, or relatively good pertinence and clinical safety in clinical application.

Description

technical field [0001] The present invention relates to the technical field of medicine, and specifically provides a pharmaceutical composition comprising chiral isomeric compounds of lysine and calcium hydrogen phosphate or calcium hydrogen phosphate 2 hydrate for preventing or treating calcium deficiency, and its preparation and application. Background technique [0002] Calcium ions are indispensable ions for various physiological activities of the body. It maintains the biological potential on both sides of the cell membrane, maintains normal nerve conduction function, etc., and the mechanism of action of some hormones is expressed through calcium ions. The main functions or mechanisms are: [0003] 1. Calcium ion is a coagulation factor and participates in the coagulation process; [0004] 2. Participate in the contraction process of muscles (including skeletal muscles and smooth muscles), and promote the beating of the heart. [0005] 3. Participate in the synthesis...

AI Technical Summary

Problems solved by technology

More importantly, there are many shortcomings or deficiencies in the preparations of the prior art! Lysine contains half of D-lysine and L-lysine. Only L-lysine is easily absorbed and utilized by the body, which has great use value for the human body, while D-lysine is not easily absorbed by the body. Absorption and utilization; although L-lysine hydrochloride granules with a single optical isomer are also publicly reported, they are limited to single-component administration

In addition, the compound lysine calcium hydrogen phosphate or tablets or granules in the prior art are also not suitable for patients with hyperchloremia, acidosis and renal insufficiency in some cases, especially when the drug is unknown or difficult to know in advance. The use of L-lysine is not limited in the current preparations, which makes the quality or nutritional or therapeutic value of the preparations limited or cannot be optimized; moreover, the current one The unit dose specifications are only 100mg of lysine hydrochloride and 100mg of calcium hydrogen phosphate or tablets or granules, and when or actually the single doses of lysine hydrochloride and calcium hydrogen phosphate reach or exceed 200mg, 300mg, 400mg, 500mg respectively , 600mg, which is not conducive to the convenience of daily use; in the preparation of doubling the dosage unit, add half of the D-lysine that is not easy to be absorbed and utilized. The larger the dosage of a unit, the longer the taking time and the greater the waste

This causes problems in manufacturing, taking convenience, transportation and packaging, or it is not suitable for clinical application, and it is not conducive to saving human resources and building a resource-saving society. This unfavorable situation has been ignored and improved for many years. , which actually causes waste of social resources and puts more pressure on environmental protection, but has yet to break through the old framework

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