The invention discloses a men's health preserving and life lengthening wine and its preparation method, and belongs to the technical field of healthcare wines. The men's health preserving and life lengthening wine comprises the following raw materials, by weight, 1-3 parts of ginseng, 2-10 parts of wolfberry fruit, 1-5 parts of Rhodiola rosea, 1-5 parts of mulberry, 2-10 parts of Cordyceps militaris, 2-10 parts of Polygonatum sibiricum, 1-3 parts of raw haw, 2-10 parts of Rhizoma Polygonati Odorati, and 100-200 parts of an above 60DEG raw wine or white wine. The preparation method comprises a step of crushing, a step of dipping, a step of percolating, a step of adding auxiliary materials, and a step of filtering to obtain the finished men's health preserving and life lengthening wine. The men's health preserving and life lengthening wine which is prepared according to the theoretic formula of traditional Chinese medicinal science has the efficacies of anti-fatigue, cancer prevention, anti-ageing, yang invigorating, blood fat reducing, blood sugar reducing and blood pressure reducing, can supplement high-quality vitamins and trace elements, and is suitable for men's health preserving.