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Medicine composition of compound amino acid injection 17AA-I and application thereof

A 17AA-I, compound amino acid technology, which is applied in drug combination, drug delivery, medical preparations containing active ingredients, etc., can solve problems such as restrictions, acid-base imbalance, and disease inability to use

Inactive Publication Date: 2014-11-19
刘力
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compound Amino Acid Injection (17AA-I), as an amino acid drug (National Drug Standard WS-10001-(HD-0847)-2002), is used for patients with insufficient protein intake, malabsorption and other amino acids that cannot meet the body's metabolic needs. It is used to improve the nutritional status of patients after surgery, but the infusion of existing preparations into the body in some cases may lead to acid-base imbalance or other adverse reactions or restrictions on indications, etc., resulting in some diseases that cannot be used or unexpected adverse problems after use etc., or restrict the clinical selectivity of the drug or the drug, making it the focus or object of research in pharmacy or pharmacology or related disciplines

Method used

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  • Medicine composition of compound amino acid injection 17AA-I and application thereof
  • Medicine composition of compound amino acid injection 17AA-I and application thereof
  • Medicine composition of compound amino acid injection 17AA-I and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0234] Embodiment 1, the preparation of compound amino acid injection (17AA-I), prescription:

[0235] L-Isoleucine 8.7g; L-Leucine 11.8g; L-Lysine Acetate 19.65g; L-Methionine 11.2g; L-Phenylalanine 10.3g; L-Threonine 11.2g g; L-Tryptophan 4.3g; L-Arginine 28.9g; L-Valine 9.5g; Glycine 32.3g; L-Histidine 7.3g; L-Tyrosine 1.65g; L-Alanine Acid 53.3g; L-proline 29.0g; L-serine 29.0g; N-acetyl-L-cysteine ​​2.2g; L-glutamic acid 22.8g; Sorbitol 500.00g; Sodium bisulfite 5.0g ;

[0236]

[0237] Preparation Process:

[0238] Weigh each raw material and auxiliary material according to the prescription; add 8000ml of water for injection into the dispensing tank, heat to boil, repeatedly vacuumize and replace with nitrogen to reduce the oxygen content in the dispensing tank, and then fill the tank with nitrogen during the whole process. Add raw and auxiliary materials sequentially between 96°C and 85°C: xylitol, antioxidant (sodium bisulfite), L-tyrosine, L-leucine, L-isoleuci...

Embodiment 2

[0240] Embodiment 2, the preparation of compound amino acid injection (17AA-I), prescription:

[0241] L-isoleucine 8.7g;

[0242] L-Leucine 11.8g;

[0243] L-Lysine acetate 19.65 g;

[0244] L-methionine 11.2g;

[0245] L-phenylalanine 10.3g;

[0246] L-Threonine 11.2g;

[0247] L-tryptophan 4.3g;

[0248] L-arginine 28.9 grams;

[0249] L-valine 9.5g;

[0250] Glycine 32.3g;

[0251] L-histidine 7.3 grams;

[0252] L-tyrosine 1.65g;

[0253] L-alanine 53.3g;

[0254] L-proline 29.0g;

[0255] L-serine 29.0g;

[0256] N-acetyl-L-cysteine ​​2.2g;

[0257] L-glutamic acid 22.8g;

[0258]Xylitol 500.0 grams;

[0259] Edetate calcium sodium 0.5 g (antioxidant);

[0260] Tartaric acid 1.0g (antioxidant)

[0261]

[0262] Preparation Process:

[0263] Weigh each raw material and auxiliary material according to the prescription; add 7500ml of water for injection into the dispensing tank, heat and boil, and repeatedly adopt vacuum pumping and nitrogen filling re...

Embodiment 3

[0265] Embodiment 3, the preparation of compound amino acid injection (17AA-I), prescription:

[0266] L-Isoleucine 8.7g; L-Leucine 11.8g; L-Lysine Acetate 19.65g; L-Methionine 11.2g; L-Phenylalanine 10.3g; L-Threonine 11.2g g; L-Tryptophan 4.3g; L-Arginine 28.9g; L-Valine 9.5g; Glycine 32.3g; L-Histidine 7.3g; L-Tyrosine 1.65g; L-Alanine L-proline 29.0g; L-serine 29.0g; N-acetyl-L-cysteine ​​2.2g; L-glutamic acid 22.8g; Sorbitol 500.0g; Edetate calcium sodium 0.5 gram, 1 gram of citric acid (antioxidant);

[0267]

[0268] Preparation Process:

[0269] Weigh each raw material and auxiliary material according to the prescription; 1), add the prescribed amount of sorbitol into a batching bucket, add 1000ml of water for injection, stir to dissolve, add 0.3 g of activated carbon, stir, heat and boil for 20 minutes, and cool to 65-80°C , nitrogen flow for 20 minutes, stand-by; 2), add 7000ml of water for injection in the concentrated mixing tank, fill nitrogen while heating...

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Abstract

The invention provides a new medicine composition of compound amino acid injection (17AA-I). The medicine composition can be used for preparing medicines suitable for patients suffering from insufficient protein intake and absorbing barrier so as not to meet metabolism requirement with amino acid and for improvement of nutriture of patients after operation and prevention or treatment of metabolic acidosis, so that the prepared products are applicable to more people in clinical or are more targeted and safer in clinical.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular, it is provided for patients whose amino acids cannot meet the metabolic needs of the body, such as insufficient protein intake and malabsorption. The pharmaceutical composition of the compound amino acid injection (17AA-I), which is also used to improve the nutritional status of patients after surgery, and its preparation and application. The product of the present invention is more suitable for patients who need to supplement 17AA-I amino acid injection under many diseases or symptoms such as metabolic acidosis or hyperchloremic metabolic acidosis, and the product of the present invention has wider safety in clinical use Or more or updated indications or adapted populations, etc. Background technique [0002] Protein is the main component of cell structure. The basic unit of protein structure is amino acid. The human body needs to take in a certain amount of protein every day to...

Claims

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Application Information

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IPC IPC(8): A61K31/4172A61K9/08A61P3/02A61P3/12A61K31/405A61K31/401A61K31/198A61K31/195
Inventor 刘力
Owner 刘力
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