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Light-sensitive medicine nano-particles as well as preparation method and application thereof

A photosensitive drug and nanoparticle technology, applied in the field of nanomaterials, can solve problems such as affecting normal tissue growth and high cytotoxicity

Active Publication Date: 2016-10-12
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Traditional cross-linking methods mostly use chemically synthesized cross-linking agents, which themselves have relatively high cytotoxicity, resulting in the resulting biomaterials being implanted into receptors, which will affect the growth of normal tissues

Method used

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  • Light-sensitive medicine nano-particles as well as preparation method and application thereof
  • Light-sensitive medicine nano-particles as well as preparation method and application thereof
  • Light-sensitive medicine nano-particles as well as preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0037] Embodiment 1, preparation TAPP cross-linked nanoparticle with genipin

[0038] Mix 1 mg / mL TAPP and 1 mg / mL genipin in a volume ratio of 3:1, adjust the pH of the system to 7-8, and react in a water bath at 40°C for 48 hours. Afterwards, centrifuge at 9500 rpm for 20 min and wash with deionized water. Centrifuge twice and dry in vacuum to obtain photosensitive drug nanoparticles, such as figure 1 Shown is the TEM image of the nanoparticles obtained after the TAPP photosensitive drug was cross-linked with genipin.

[0039] Depend on figure 1 It can be seen that the photosensitive drug nanoparticles cross-linked with TAPP and genipin prepared in the present invention have uniform size and uniform dispersion, and the size is 150-300 nm.

Embodiment 2

[0040] Embodiment 2, preparation ALA cross-linked nanoparticles with genipin

[0041] Mix 1 mg / mL ALA and 1 mg / mL genipin at a volume ratio of 1:2, adjust the pH of the system to 7-8, and react in a water bath at 40°C for 48 hours. Afterwards, centrifuge at 9500 rpm for 20 min and wash with deionized water. Centrifuge twice and dry in vacuum to obtain photosensitive drug nanoparticles, such as figure 2 Shown is the SEM image of the nanoparticles obtained after cross-linking ALA photosensitive drug with genipin.

[0042] Depend on figure 2 It can be seen that the photosensitive drug nanoparticles cross-linked with ALA and genipin prepared in the present invention have a uniform size and a particle diameter of 150-300 nm.

Embodiment 3

[0043] Embodiment 3, preparation DOX cross-linked nanoparticle with genipin

[0044] Mix 1 mg / mL DOX and 1 mg / mL genipin at a volume ratio of 2:1, adjust the pH of the system to 7-8, and react in a water bath at 40°C for 48 hours. Afterwards, centrifuge at 9500 rpm for 20 min and wash with deionized water. Centrifuge twice and dry in vacuum to obtain photosensitive drug nanoparticles. Such as image 3 Shown is the state light scattering (DLS) data graph of nanoparticles cross-linked with DOX and genipin.

[0045] Depend on image 3 It can be seen that the photosensitive drug nanoparticles cross-linked by DOX and genipin prepared in the present invention have a uniform size and a particle diameter of 150-300 nm.

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Abstract

The invention discloses light-sensitive medicine nano-particles as well as a preparation method and application thereof. The light-sensitive medicine nano-particles disclosed by the invention are prepared from a light-sensitive medicine with an amino and a cross-linking agent through a reaction; the mass ratio of the light-sensitive medicine with the amino to the cross-linking agent is 1: (0.1 to 4.0). The preparation method of the light-sensitive medicine nano-particles comprises the following steps: mixing the light-sensitive medicine with the amino and the cross-linking agent; adjusting the pH value of the system and reacting to obtain the light-sensitive medicine nano-particles. The preparation method of the light-sensitive medicine nano-particles is simple; the light-sensitive medicine nano-particles can be effectively accumulated in cancer cells and can be used for preparing medicines for treating tumors.

Description

technical field [0001] The invention relates to a photosensitive drug nanoparticle and a preparation method and application thereof, belonging to the field of nanomaterials. Background technique [0002] Photodynamic therapy (Photodynamic Therapy.PDT) is a new cancer treatment technology developed in recent decades. This treatment technology mainly uses light to excite photosensitizer molecules (Photosensitizer, PS) inside cancer cells to generate highly cytotoxic singlet oxygen, so as to kill cancer cells inside cells and avoid damage to normal tissues. Photodynamic therapy is a new cancer treatment technology besides the three traditional tumor treatment methods such as surgery, chemotherapy and radiotherapy. Compared with traditional treatment techniques, it has the advantages of less toxic and side effects, broad-spectrum anti-cancer, minimally invasive or non-invasive, no drug resistance, and repeated application of treatment, which makes thousands of cancer patients b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/48A61K9/14A61K31/195A61K31/704A61K31/409A61P35/00
CPCA61K9/145A61K31/195A61K31/409A61K31/704A61K41/0057A61K41/0061A61K41/0071A61K2300/00
Inventor 李峻柏秦晨晨费进波崔巍
Owner INST OF CHEM CHINESE ACAD OF SCI
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