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Pharmaceutical application of nuciferine and its analogues

The technology of an analog, lotus leaf base, which is applied in the field of treating or preventing hyperuricemia, can solve problems such as complex composition, and achieve the effects of less dosage, good effect and clear composition.

Active Publication Date: 2017-03-08
GUANGDONG QIFANG MEDICINES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, Chinese Patent No. 201510567893.2 discloses a pharmaceutical composition including nuciferine, almond kernel, lapis lazuli, liensinine, jujube saponin and other raw materials for the prevention and treatment of gout. However, the composition of the pharmaceutical composition is complex, especially Nuciferine accounts for less than 5% of the API

Method used

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  • Pharmaceutical application of nuciferine and its analogues
  • Pharmaceutical application of nuciferine and its analogues
  • Pharmaceutical application of nuciferine and its analogues

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Experimental program
Comparison scheme
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Embodiment Construction

[0025] The content of the present invention will be further described through specific experiments below. If not detailed, you can refer to "Modern Pharmaceutical Experiment Course", "Chinese Pharmacopoeia", and relevant regulations and guidelines of drug regulatory authorities (eg, CFDA).

[0026] 1. Drugs to be tested

[0027] Nuciferine: can be purchased from Xi'an Kangnuo Chemical Co., Ltd., with a purity of 98%;

[0028] The compound represented by formula II: can be purchased from Chengdu Atmo Biotechnology Co., Ltd., with a purity of ≥98%.

[0029] 2. Experimental method

[0030] After one week of adaptive feeding, the ICR mice were randomly divided into 5 groups. In addition to being fed with the same basal diet, (1) normal group: intragastric administration of distilled water; (2) model group: intragastric administration of hypoxanthine and niacin; (3) drug group 1: intragastric administration of hypoxanthine, niacin and nuciferine (10mg / kg); (4) drug group 2: intr...

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Abstract

The invention provides combined application of nuciferine and analogue thereof and a drug. The drug is used for treating or preventing hyperuricemia and reducing the serum uric acid level.

Description

technical field [0001] The invention belongs to the technical field of medicine. Specifically, the invention provides the pharmaceutical application of nuciferine and its analogues and pharmaceutical preparations thereof, which are used to treat or prevent hyperuricemia, thereby eliminating or reducing the onset of gout. Background technique [0002] The structure of nucferine (nucferine) is as described in formula I, and it was originally extracted from lotus leaf. For example, Chinese Patent No. 200910117596.2 discloses extracting a variety of effective monomer components including nuciferine from lotus leaves, wherein compounds such as nuciferine can be used as acetylcholine inhibitors, which can be used to treat Alzheimer's disease, intestinal obstruction, myasthenia gravis, and glaucoma. [0003] [0004] Chinese Patent No. 201110431431.X discloses the application of nuciferine in the preparation of Malassezia inhibitors, so as to prevent or treat excessive dandruff...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/472A61K31/473A61P19/06
CPCA61K31/472A61K31/473A61K2300/00
Inventor 刘军杨春玮
Owner GUANGDONG QIFANG MEDICINES CO LTD