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SiO2 gold nanorod composite particle preparation method

A technology of composite particles and gold nanorods, applied in nanotechnology, nanotechnology, nanotechnology for materials and surface science, etc., can solve the problems of particle aggregation, local surface LSPR absorption peak shift, strong biological toxicity, etc. , to achieve good repeatability and improve application value

Inactive Publication Date: 2016-10-26
潘忠宁
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

However, CTAB has strong biological toxicity, and the existence of CTAB bilayer molecules also makes it difficult for other molecules to directly interact with the GNR surface.
After reducing the concentration of CTAB, GNR often exhibits particle aggregation, which leads to a very serious shift of its local surface LSPR absorption peak; after completely removing the surfactant, GNR will experience irreversible particle aggregation and completely lose its optical properties.
Moreover, as a drug loading platform, the specific surface area of ​​GNR is too small, which severely limits the drug loading capacity.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0013] Take 103 μL of 1 mg / mL chloroauric acid solution and mix it with 0.5 mL of 0.2 mol / L CTAB, and add 100 μL of newly prepared 0.227 mg / mL NaBH ４ solution, under vigorous stirring, was added to the above solution, the color of the solution changed from yellow to brownish yellow, and the stirring was stopped after 2 minutes to obtain seed crystals, which should be kept at 35°C for 25 minutes before use;

[0014] Prepare growth solution, put 1.8g CTAB and 0.22g 5-BrSA in a beaker and dissolve them with 95mL warm water (50-70℃), then add 3.8mL silver nitrate (AgNO3) solution (0.004mol / L) and 2.5mL Hydrochloric acid aqueous solution (1mol / L), the solution was cooled to 30°C, then 2.06mL of 10mg / mL chloroauric acid solution was added to it, the mixture was kept at 32°C for 20min, and then 0.4mL of 0.064mol / L Ascorbic acid, the solution was vigorously stirred for 30s until it became colorless, and the growth solution was obtained;

[0015] To prepare GNR, take 0.08 mL of seed c...

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Abstract

The invention discloses a SiO2 gold nanorod (GNR) composite particle preparation method, which comprises the steps of preparing growth solution, preparing GNR, and preparing GNR-SiO2. The method disclosed by the invention achieves good repeatability, ideal near-infrared excitation window and ideal light-thermal conversion efficiency, and improves the application value of the GNR in the biological field.

Description

technical field [0001] The invention relates to a material synthesis method, in particular to a preparation method of SiO2 gold nanorod composite particles. Background technique [0002] Due to its unique physical and chemical properties, gold nanoparticles have always been a hot spot in the research of nanomaterials, among which gold nanorods (GNRs) are the most prominent. Because the localized surface plasmon resonance (LSPR) of GNR is highly adjustable, it can ensure that its excitation window is in the near-infrared region with stronger tissue penetration and less cytotoxicity. Therefore, GNR has a wide range of applications in the field of tissue cell imaging. In addition, GNR can convert light energy into heat energy very efficiently through the photothermal effect. The generated thermal energy can not only be directly used for thermal treatment of tumor cells, but also be used to trigger the release of drugs in nanocarriers. [0003] The preparation method of GNR u...

Claims

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Application Information

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IPC IPC(8): B22F9/24B82Y40/00B82Y30/00
CPCB22F9/24B82Y30/00B82Y40/00
Inventor 潘忠宁
Owner 潘忠宁
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