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Liposome-based immunotherapy

A technology for liposomes and autoimmune diseases, applied in the medical field, can solve problems such as slowing down the progress, and achieve the effects of convenient uniformity, guaranteed uniformity, and easy access

Active Publication Date: 2016-10-26
FUNDACIO INST DINVESTIGACIO & CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, limited understanding of the intricate details of different autoimmune diseases has substantially slowed progress in the field

Method used

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Experimental program
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Effect test

Embodiment

[0093] Materials and methods:

[0094] Preparation of liposomes

[0095] Phosphatidylserine (PS) and phosphatidylcholine (PC) were purchased from Lipoid, Steinhausen, Switzerland. Cholesterol (CHOL) was purchased from Sigma Aldrich, Saint Louis, USA. The lipid-conjugated fluorescent dye Oregon Green 488DHPE was purchased from Invitrogen, California, USA. Alexa Fluor 750 was obtained from Invitrogen in the form of its succinimide ester and was conjugated to lipid DOPE supplied by Avanti Polar Lipids (Alabaster, USA). Peptides of SEQ ID NO: 1 (GIVDQCCTSICSLYQLENYCN) and SEQ ID NO: 2 (FVKQHLCGSHLVEALYLVCGERGFFYTPMS) derived from insulin A chain and insulin B chain, respectively, were obtained from Genosphere Biotechnologies (Paris, France) with >95% purity and removal of trifluoro Acetic acid (tfa). The peptide of SEQ ID NO: 3 (YRSPFSRVVHLYRNGK) derived from myelin oligodendrocyte glycoprotein (MOG) was obtained from Institut de Recerca Biomèdica de Barcelona, ​​IRBB, Barce...

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Abstract

The present invention provides a liposome encapsulating an autoantigen, wherein the liposome has a size comprised from 500 to 15000 nm and the liposome membrane comprises phosphatydilserine (PS) in an amount comprised from 10 to 40% by weight with respect to the total membrane liposomal composition. Pharmaceutical or veterinary compositions comprising a therapeutically effective amount of said liposome are also provided. Further, the invention provides liposomes and pharmaceutical or veterinary compositions as defined above for use as a medicament, particularly for the treatment of autoimmune diseases. Finally the present invention provides liposomes and pharmaceutical or veterinary compositions as defined above for use in the restoration of tolerance to self in a patient suffering from an autoimmune disease.

Description

[0001] The present invention relates to the field of medicine. In particular, the present invention provides liposomes encapsulating autoantigens for use in the prevention or treatment of autoimmune disorders. Background technique [0002] Autoimmunity is the failure of an organism to recognize its own constituent parts by itself, resulting in an immune response against its own cells and tissues. Any disease caused by an abnormal immune response is called an autoimmune disease. Prominent examples include type 1 diabetes (T1D), lupus, rheumatoid arthritis, multiple sclerosis (MS), Addison's disease, celiac disease, dermatomyositis, Hashimoto's thyroiditis, myasthenia gravis, pernicious anemia, Reactive arthritis, Sjogren syndrome. [0003] These diseases, which are often chronic, debilitating and life-threatening, have been calculated to affect 7% to 10% of the population in developed countries. Autoimmune-related medical care costs continue to increase, as autoimmune condit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/00A61K9/127A61P3/10
CPCA61K39/0008A61K2039/577A61K9/127A61P1/00A61P17/00A61P17/02A61P17/06A61P19/02A61P21/00A61P21/04A61P25/00A61P29/00A61P37/02A61P5/00A61P5/14A61P5/18A61P7/00A61P7/06A61P3/10
Inventor 丹尼尔·马斯波奇科马玛拉安东尼娅·玛丽亚·卡诺萨拉比尔玛尔塔·维沃斯皮厄玛·普约尔奥特内尔胡安·维达格尔奥特内尔
Owner FUNDACIO INST DINVESTIGACIO & CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL
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