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High strength degradable intraosseous fixation composite material

A composite material and high-strength technology, applied in medical science, surgery, etc., can solve problems such as false joints, affecting postoperative effects, and stress shielding

Inactive Publication Date: 2016-11-02
YUANRONG BIOLOGICAL PHARMA WUXI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional intervertebral fusions have stress shielding, subsidence, pseudarthrosis and other related complications, which affect the postoperative effect.

Method used

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  • High strength degradable intraosseous fixation composite material
  • High strength degradable intraosseous fixation composite material
  • High strength degradable intraosseous fixation composite material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1: Preparation of polylactic acid magnesium alloy composite material

[0027] (1) Soak the magnesium alloy pipe with hydrogen fluoride for 24 hours, wash and dry with 75% ethanol, first dissolve the polymer PLLA in chloroform solvent to make a 25% fluid solution, inject it into the pipe, heat and melt, vacuumize the air bubbles Take it out and get it, wherein the weight percentage of magnesium alloy tube: PLLA is (0.5:1);

Embodiment 2

[0028] (2) The polymer PLLA powder is packed in the magnesium alloy tubing of equal mass fraction, heated and melted, and the air bubbles are taken out by vacuuming; Example 2: Preparation of polylactate magnesium alloy composite material

[0029] Put the poly-L-lactic acid powder into the magnesium alloy tube, heat and melt, and vacuumize to extract the air bubbles. The weight percentage of the magnesium alloy tube: PLLA (viscosity average molecular weight: 200,000) is (1:1);

Embodiment 3

[0030] Example 3: Preparation of polylactic acid magnesium alloy composite material

[0031] The polymer PLLA is melted, injected into the magnesium alloy hollow pipe through an injection machine or a pouring machine, cooled and formed, and the weight percentage of the magnesium alloy pipe:PDLA (viscosity-average molecular weight: 500,000) is (1:2);

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Abstract

The invention discloses a high strength degradable intraosseous fixation composite material. A magnesium alloy pipe is filled with a high polymer material to form a high strength degradable sandwich composite material, by weight percentage, the degradable magnesium alloy pipe accounts for 5-70%, and the balance is the high polymer material, which is preferably polylactic acid. For the degradation product, because of the neutralization reaction of magnesium hydroxide and lactic acid, later-stage rapid degradation of polylactic acid is accelerated, thus solving the problem of aseptic inflammation caused by acidic accumulation in a degradation process of polylactic acid during clinical application. And magnesium alloy degradation and basically slight expansion of polylactic acid at the early stage further strengthen the support function of the composite material, therefore the high strength degradable intraosseous fixation composite material has very good clinical application prospect.

Description

technical field [0001] The invention relates to a high-strength bone internal fixation composite material, which forms a high-strength composite material by filling a magnesium alloy tube with a polymer material, and belongs to the field of degradable biomaterials. Background technique [0002] According to clinical data statistics, there are about 20 million cases of fractures in bone diseases every year in the country, and 15% of cases need surgical internal fixation, about 3 million cases. At present, most of them use metal internal fixation. At present, most of the absorbable products used in China are used in non-weighing bone parts. There are about 390,000 cases per year, accounting for only about 13% of the entire market. If products for load-bearing bones can be produced, when the products are supported in the body It is an ideal product among orthopedic internal fixation materials to maintain the corresponding support strength, meet the needs of bone growth, and con...

Claims

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Application Information

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IPC IPC(8): A61L31/12A61L31/14A61L31/18
Inventor 李斌白晶张文芳
Owner YUANRONG BIOLOGICAL PHARMA WUXI CO LTD
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