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A nanofiber-reinforced absorbable bone internal fixation material and its preparation method

A nanofiber, fixing material technology, applied in fiber processing, surgery, filament/thread forming, etc., can solve the problems of obvious brittleness, low toughness, poor crack resistance, etc.

Active Publication Date: 2021-04-27
STAR SPORTS MEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] With the iterative update of medical technology, although traditional metals have high mechanical strength and fatigue resistance, which can meet the performance requirements of clinical operations, metal materials cannot be degraded in the body after they are implanted into the human body. Afterwards, a second operation is required to remove it, causing secondary injury to the patient.
In recent years, absorbable fixed grafts have received extensive attention due to their unique advantages, but there are also a series of problems, but compared with other non-absorbable materials, they also have certain limitations, such as poor crack resistance, low toughness, and brittleness. Obviously, the degradation rate is inconsistent with the bone ingrowth rate, etc., to a certain extent, it affects the appearance and service life of the absorbable fixation material, and the most important thing is that it will seriously threaten the life safety of patients.

Method used

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  • A nanofiber-reinforced absorbable bone internal fixation material and its preparation method
  • A nanofiber-reinforced absorbable bone internal fixation material and its preparation method
  • A nanofiber-reinforced absorbable bone internal fixation material and its preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0036] In Example 1, the nanofiber-reinforced absorbable bone internal fixation material is composed of polyglycolide-lactide copolymer nanofibers, polyglycolide-lactide copolymer pellets, and β-tricalcium phosphate; , the consumption of polyglycolide-lactide copolymer nanofiber is 15g, the consumption of polyglycolide-lactide copolymer pellet is 65g, the consumption of β-tricalcium phosphate is 20g.

[0037] The preparation process is:

[0038] 1. Using electrospinning technology to prepare polyglycolide-lactide copolymer nanofibers, specifically including: adding polyglycolide-lactide high-molecular polymers into a solvent, performing magnetic stirring, and serving as an electrospinning solution; Adding the prepared electrospinning solution into the nozzle for electrospinning to obtain polyglycolide-lactide copolymer nanofibers;

[0039] The concentration of the electrospinning solution was 20%, the magnetic stirring time was 6 h, the electrospinning voltage was 20 kV, the ...

Embodiment 2

[0045] The nanofiber-reinforced absorbable bone internal fixation material is composed of polylactic acid nanofibers, polyglycolide-lactide copolymer pellets, and β-tricalcium phosphate artificial bone material; wherein, the dosage of polylactic acid nanofibers and nanofibers is 15g, the dosage of polyglycolide-lactide copolymer pellets is 65g, and the dosage of β-tricalcium phosphate artificial bone material is 20g.

[0046] The preparation process is:

[0047] 1. Using electrospinning technology to prepare polylactic acid nanofibers, specifically including: adding polylactic acid polymers to chloroform solvents, performing magnetic stirring, as an electrospinning solution; adding the prepared electrospinning solution to the nozzle, Electrospinning is carried out to obtain polylactic acid nanofibers;

[0048] The concentration of electrospinning solution was 20%, the time of magnetic stirring was 6h, the voltage of electrospinning was 20kV, the advancing speed of spinning so...

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Abstract

The invention provides a nanofiber-reinforced absorbable bone internal fixation material and a preparation method thereof. The nanofiber-reinforced bone internal fixation material is mainly composed of biodegradable polymer materials, nanofibers and artificial bone materials; wherein the surface of the nanofibers is modified or modified, and the content of the nanofibers accounts for 1% of the material. 10-20% of the total weight; the content of the biodegradable polymer material accounts for 60-80% of the total weight of the material; the artificial bone material accounts for 10-20% of the total weight of the material. The nanofiber-reinforced absorbable bone internal fixation material of the present invention overcomes the multi-scale fracture characteristics of common bone internal fixation materials; the nanofiber has the characteristics of large specific surface area, high porosity, strong modification ability and high elastic modulus, which greatly improves Improve the mechanical properties of absorbable bone internal fixation materials, and at the same time further promote bone resorption and bone ingrowth, and speed up postoperative recovery.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a nanofiber-reinforced absorbable bone internal fixation material and a preparation method thereof. Background technique [0002] With the iterative update of medical technology, although traditional metals have high mechanical strength and fatigue resistance, which can meet the performance requirements of clinical operations, metal materials cannot be degraded in the body after they are implanted into the human body. Afterwards, a second operation is required to remove it, causing secondary injury to the patient. In recent years, absorbable fixed grafts have received extensive attention due to their unique advantages, but there are also a series of problems, but compared with other non-absorbable materials, they also have certain limitations, such as poor crack resistance, low toughness, and brittleness. Obviously, the degradation rate is not consistent with the bone ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/12A61L31/14B29C45/00D01D5/00D01D5/247
CPCA61L31/127A61L31/129A61L31/14A61L31/146A61L31/148B29C45/00D01D5/003D01D5/247C08L67/04
Inventor 董文兴赵树宇杨腾飞
Owner STAR SPORTS MEDICINE CO LTD
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