Pharmaceutical composition for preventing and treating rhinitis and preparation method thereof
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A composition and drug technology, applied in the field of medicine, can solve the problems of patients with repeated illnesses, toxic side effects, nasal mucosa damage, etc., and achieve the effect of broad application prospects
Inactive Publication Date: 2016-11-09
成都萌斯特生物技术有限公司
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[0003] At present, there is no effective treatment for rhinitis in Western medicine, which can easily cause recurrence of the patient's condition; some drugs have obvious toxic and side effects, and may even cause drug-induced rhinitis, or cause damage to the nasal mucosa
For example, long-term use of ephedrine nasal drops can damage the cilia structure of the nasal mucosa and further aggravate rhinitis; nasal drops whose main component is nazoline have been proven to cause drug-induced rhinitis; commonly used drug cetirizine can cause drowsiness , drowsiness, headache, dizziness, excitement, dry mouth and gastrointestinal discomfort and other adverse reactions
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Embodiment 1
[0020] The preparation of embodiment 1 ethanol extract of the present invention
[0022] Extraction process: 8 times the volume of 60% v / v ethanol aqueous solution for the above 10 medicinal flavors, reflux extraction twice, each time for 3 hours, the reflux liquid was combined to recover ethanol, concentrated, and dried to a density of 1.20-1.25g / ml (60°C) , get extract.
[0023] The above obtained extract can be further prepared to obtain hard capsules, soft capsules, granules or tablets according to conventional methods.
[0024] Prove the beneficial effects of the present invention below by drug effect experiment.
experiment example 1
[0025] Experimental Example 1 Drug efficacy experiment of the pharmaceutical composition of the present invention
[0026] 1. Test drugs and reagents
[0027] Jiemin Decoction: Formula granules are used. The composition of the prescription is: Rubia 10g, Comfrey 10g, Fangfeng 6g, Chanyi 3g, Dilong 10g, Xu Changqing 10g, Wumei 10g. The traditional Chinese medicine is dissolved in distilled water in proportion to contain 3g of crude drug per milliliter.
[0028] Modified Jiemin Decoction (that is, the pharmaceutical composition of the present invention): formula granules are adopted, and the prescription is composed of: Rubia 9g, Comfrey 9g, Fangfeng 6g, Cicada slough 3g, Dilong 9g, Xu Changqing 9g, Ume 9g, Codonopsis 12g, Poria cocos 12g, Atractylodes macrocephala 12g. The traditional Chinese medicine is dissolved in distilled water in proportion to contain 3g of crude drug per milliliter.
[0029] Cetirizine: produced by Yangzijiang Pharmaceutical Industry, 10mg / tablet. Ov...
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Abstract
The invention discloses a pharmaceutical composition for preventing and treating rhinitis. The pharmaceutical composition is a preparation prepared from the following active pharmaceutical ingredients in parts by weight: 7 to 11 parts of radix rubiae, 7 to 11 parts of radix arnebiae seu lithospermi, 5 to 7 parts of radix sileris, 2 to 4 parts of cicada slough, 7 to 11 parts of earthworm, 7 to 11 parts of radix cynanchi panicullati, 7 to 11 parts of smoked plums, 10 to 15 parts of radix codonopsis, 10 to 15 parts of poria cocos and 10 to 15 parts of bighead atractylodes rhizome. The composition has the advantages that the traditional recipe Jiemin decoction of traditional Chinese medicine is used as a foundation recipe; on the basis of original recipe, three kinds of traditional Chinese medicine including the radix codonopsis, the poria cocos and the bighead atractylodes rhizome are added; all raw material medicine achieves the synergistic interaction effect in the specific proportion; the medicine with the obvious rhinitis treatment effect is obtained. Medicine effect experiments show that compared with that of clinically frequently-used Jiemin decoction and cetirizine, the rhinitis treatment effect of the pharmaceutical composition is obviously improved; wide application prospects are realized.
Description
technical field [0001] The invention relates to a pharmaceutical composition for preventing and treating rhinitis and a preparation method thereof, belonging to the field of medicine. Background technique [0002] Rhinitis is an inflammatory disease of the nasal cavity. It is an inflammation of the nasal mucosa caused by viruses, bacteria, allergens, various physical and chemical factors, and certain systemic diseases. Its clinical manifestations are nasal congestion, sneezing, and excessive nasal discharge. During rhinitis attack, symptoms such as nasal congestion, constant sneezing, runny nose and headache have seriously affected people's normal work and life. [0003] At present, there is no effective treatment for rhinitis in Western medicine, which can easily cause recurrence of the patient's condition; some drugs have obvious toxic and side effects, and may even cause drug-induced rhinitis, or cause damage to the nasal mucosa. For example, long-term use of ephedrine n...
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