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A kind of extract and application thereof

A technology for the round leaves and extracts of Shanxiang, which is applied in the direction of drug combination, food science, plant raw materials, etc., can solve problems such as gastrointestinal reactions, ineffective effects, liver and kidney damage, achieve good hyperlipidemia, and save extraction time , the effect of preventing and treating hyperlipidemia

Active Publication Date: 2019-10-11
HUNAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When these drugs are used for a long time, the effect may not be good, or there may be serious side effects, such as causing greater damage to the liver and kidneys, and severe gastrointestinal reactions, etc.

Method used

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  • A kind of extract and application thereof
  • A kind of extract and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The present embodiment relates to the extract of the round leaf of the present invention, and its extraction method comprises the following steps:

[0024] 1) Grind the dry leaves of Turpinia arguta Seem. to 60-80 meshes, and mix water and Turpinia arguta Seem. Cellulase with a mass of 3.5% of the aqueous solution was extracted for 30 minutes at an ultrasonic power of 200 W and a temperature of 35° C., and then centrifuged at 5000 r / min after extraction, and the supernatant A was collected after 10 minutes;

[0025] 2) Concentrate the supernatant A of step (1) to a dry dosage of 0.5g / ml, add an absolute ethanol solution 4 times its volume to the concentrated product and mix well, when the ethanol concentration in the solution is 80% , let it stand at 4°C for 12 hours, then centrifuge at 5000 rpm, collect the supernatant after 10 minutes, concentrate until it has no alcohol smell, and then obtain the extract of Cymbidium rotundum.

Embodiment 2

[0027] The present embodiment relates to the extract of the original leaves of Shanxiang according to the present invention, and its extraction method comprises the following steps:

[0028] 1) Grind the dried leaves of Turpinia arguta Seem. to 60-80 meshes, and mix water and the original leaf powder of Turpinia arguta Seem. at a ratio of 40:1 to the obtained Turpinia arguta Seem. 4.0% cellulase in the aqueous solution was extracted at an ultrasonic power of 300W and a temperature of 25° C. for 40 minutes, then centrifuged at 4000 r / min after extraction, and the supernatant A was collected after 15 minutes;

[0029] 2) Concentrate the supernatant A of step (1) to a dry dosage of 0.8g / ml, add an absolute ethanol solution 3 times its volume to the concentrated product and mix well, when the ethanol concentration in the solution is 85% , let it stand at 2°C for 24 hours, then centrifuge at 5000 rpm, collect the supernatant after 10 minutes, concentrate until it has no alcohol sme...

Embodiment 3

[0031] The present embodiment relates to the extract of the original leaves of Shanxiang according to the present invention, and its extraction method comprises the following steps:

[0032] 1) Grind the dried leaves of Turpinia arguta Seem. to 60-80 meshes, and mix water and Turpinia arguta Seem. with the ratio of solid to liquid of 35:1 for the obtained Turpinia arguta Seem. 3.75% cellulase in the aqueous solution, extracted at 250W ultrasonic power and 30°C for 35min, centrifuged at 4000r / min after extraction, and collected supernatant A after 15min;

[0033] 2) Concentrating the supernatant A of step (1) until the dry drug amount is 1g / ml, adding 3 times the volume of dehydrated ethanol solution to the concentrated product and mixing, when the ethanol concentration in the solution is 75%, Let it stand at 2°C for 24 hours, then centrifuge at 5000 rpm, collect the supernatant after 10 minutes, concentrate until it has no alcohol smell, and then obtain the extract of Cymbidiu...

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Abstract

The invention relates to a folium turpiniae extract. The folium turpiniae extract is extracted through the following methods: (1) carrying out enzymolysis on an aqueous solution containing folium turpiniae powder by using cellulase in the presence of ultrasonic waves, centrifuging an enzymolysis solution, and then, collecting supernatant; (2) concentrating the supernatant, then, adjusting the concentration of ethanol in the concentrate to 75% to 85%, carrying out low-temperature standing, carrying out centrifuging to collect secondary supernatant, and carrying out concentrating until ethanol in the secondary supernatant is removed, thereby obtaining the folium turpiniae extract. According to the folium turpiniae extract provided by the invention, the extraction method is simple, and the cost is low; the folium turpiniae extract has a blood fat reducing effect and can be prepared into pharmaceutical compositions for reducing blood fat, so that the application prospect is broad.

Description

technical field [0001] The invention relates to the field of blood lipid-lowering medicines, in particular to an extract of Cynorrhizae round leaves. Background technique [0002] Hyperlipidemia refers to the high level of blood lipids, which is one of the important risk factors for coronary heart disease, atherosclerosis and other diseases that seriously endanger human health. With the improvement of people's living standards and changes in living habits, the incidence of the disease The age of onset is also advanced, and the number of people who die every year because of hyperlipidemia is also increasing. It is of great significance to study effective methods to prevent and treat the occurrence of hyperlipidemia. At present, the commonly used oral hypolipidemic drugs in clinic are statins (simvastatin, mevastatin, pravastatin, etc.), nicotinic acid (nicotinoinosinate, acipimox, etc.), fibrates (bezabenzidine, etc.) Mainly western medicines such as fenofibrate, gemfibrozil...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61P3/06A23L33/105
Inventor 林丽美夏伯候廖端芳周亚敏
Owner HUNAN UNIV OF CHINESE MEDICINE
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