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Method for ultrasonic-aqueous extraction of scutellarin from shortscape fleabane herb

A technology of scutellarin and scutellaria, applied in chemical instruments and methods, sugar derivatives, sugar derivatives, etc., can solve the problems of solvent residual environment, high solvent cost, low extraction efficiency, etc., and achieve a simple waste liquid treatment method. , The effect of reducing the extraction cost and extracting less impurities

Active Publication Date: 2016-11-23
BEIJING LUORUI BIOLOGICAL TECH CO LTD
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AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a fast, efficient and safe extraction method from Erigeron breviscapus for the problems of high solvent cost, large dosage, low extraction efficiency, environmental pollution caused by solvent residue, and large-scale production safety in the existing extraction method. A New Approach to Scutellarin

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  • Method for ultrasonic-aqueous extraction of scutellarin from shortscape fleabane herb

Examples

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Effect test

example 1

[0019] Take 100.0 grams of the whole herb of scutellaria breviscapus (the content of scutellarin is 3.14%), and grind it to 20 mesh. Add 4.0 liters of water, the water temperature is controlled at 50° C., ultrasonically extract for 1 hour, filter and centrifuge the scutellaria breviscapus water extract to obtain the scutellaria breviscapus water extract. The water extract of scutellaria scutellaria was adsorbed to saturation with AB-8 resin, and the adsorption column was desorbed with acetic acid-ethanol solution to obtain the eluate, which was concentrated under reduced pressure to obtain 9.3 grams of scutellarin crude extract, the content of which was 28.9% (HPLC).

example 2

[0021] Take 5.0 kg of the whole herb of scutellaria breviscapus (the content of scutellarin is 3.48%), and grind it to 40 mesh. 200.0 liters of water was added, the water temperature was controlled at 55° C., ultrasonic extraction was performed for 1 hour, and then the water extract of scutellaria scutellaria was filtered and centrifuged to obtain the water extract of scutellaria breviscapus. The water extract of scutellaria scutellaria was adsorbed to saturation with D101 resin, and the adsorption column was desorbed with acetic acid-ethanol solution to obtain the eluent, which was concentrated under reduced pressure to obtain 540.1 g of scutellarin crude extract, with a scutellarin content of 28.3% (HPLC).

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Abstract

The invention relates to the technical field of extraction of scutellarin, in particular to a method for obtaining a crude scutellarin product through ultrasonic-aqueous solution extraction, adsorption by macroporous adsorption resin, elution by an organic solvent and vacuum concentration after dried shortscape fleabane herb is ground. The extraction process comprises the following steps: 1, the dried shortscape fleabane herb is ground and mixed with an aqueous solvent, and a shortscape fleabane herb water extract is obtained through an ultrasonic extraction process; 2, the shortscape fleabane herb water extract is filtered and centrifuged, a product is directly adsorbed by the macroporous adsorption resin, eluted and concentrated, and the crude scutellarin product is obtained. The method adopts the ultrasonic-aqueous technology instead of organic solvent extraction to extract the scutellarin and can still reach the same yield, the solvent cost is low, the safety is high, and environmental pollution is avoided; the water extract is directly adsorbed by the macroporous adsorption resin, eluted and concentrated under vacuum, and the crude scutellarin product with higher scutellarin content is obtained.

Description

technical field [0001] The invention relates to the technical field of extraction of scutellarin, in particular to the ultrasonic extraction technology of aqueous solution of scutellarin. Background technique [0002] Erigeron breviscapus, also known as Erigeron breviscapus, is the dry whole herb of Asteraceae breviscapita, mainly distributed in Southwest China, and is a commonly used traditional Chinese medicine. Scutellarin has various pharmacological effects, such as dilating cerebral blood vessels and coronary vessels, improving microcirculation, inhibiting platelet aggregation, anticoagulation, anti-myocardial infarction, preventing cerebral hypoxia and renal failure, etc. Clinically, it is mainly used to treat paralysis after stroke, coronary heart disease, etc. A variety of chemical components have been isolated and identified from Breviscapus, including flavonoids, benzoic acids, caffeoylquinic acids, γ-pyrone, terpenes, essential oils, etc., and have been identifie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07C07H1/08
Inventor 夏传递肖虎王惠芳焦燕玲
Owner BEIJING LUORUI BIOLOGICAL TECH CO LTD