Unlock instant, AI-driven research and patent intelligence for your innovation.

Water-soluble iron ion fluorescent probe and preparation method thereof

A fluorescent probe, water-soluble technology, used in fluorescence/phosphorescence, material analysis by optical means, instruments, etc., can solve the problems of living organism damage, toxicity, poor water solubility, etc., to achieve good anti-interference ability, excellent choice sexual effect

Active Publication Date: 2016-12-07
CHANGZHOU VOCATIONAL INST OF ENG
View PDF2 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the iron ion fluorescent probes have poor water solubility and need to add a certain proportion of organic solvents, which greatly limits their application, especially in aqueous environments containing living organisms, because the organisms lack such of organic solvents
If additional organic solvents are added, as organic solvents are often toxic and can cause damage to living organisms

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Water-soluble iron ion fluorescent probe and preparation method thereof
  • Water-soluble iron ion fluorescent probe and preparation method thereof
  • Water-soluble iron ion fluorescent probe and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The preparation method steps of embodiment 1 iron ion fluorescent probe compound C are as follows:

[0022] Synthesis of rhodamine 6G derivative (A): 2 mmol of rhodamine 6G was dissolved in 20 ml of hot ethanol, 1,3-propanediamine was added dropwise, and heated to reflux for 6 hours. The solution was cooled to room temperature, and a solid precipitated out, which was recrystallized with acetonitrile to obtain white crystal A. ( 1 H-NMR (CDCl 3 ):δ7.95(d,1H),7.47(t,2H),7.05(d,1H),6.34(s,2H),6.23(s,2H),3.50(t,2H),3.24(t, 4H),2.39(t,2H),1.90(s,6H),1.36(t,6H),1.19(m,2H))

[0023] The synthesis of polyethylene glycol methoxychloroacetate (B): polyethylene glycol monomethyl ether (such as MPEG2000, its molecular weight is about 2000, certainly, also can adopt the MPEG of other molecular weights) 10g, 5mmol, dissolve in Dichloromethane 20ml, triethylamine 2.09ml, 15mmol, add chloroacetyl chloride 7.95ml, 100mmol dropwise under N2 atmosphere, stir overnight in the dark, pre...

Embodiment 2

[0025] Embodiment 2 performance experiment of iron ion fluorescent probe compound

[0026] 1) Selectivity of iron ion probe

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a water-soluble iron ion fluorescent probe, and the fluorescent probe molecule comprises a structure which is shown in the following figure. The invention also discloses a preparation method of the water-soluble iron ion fluorescent probe.

Description

technical field [0001] The invention belongs to the field of ion probe new materials. In particular, it relates to a kind of OFF-ON fluorescent probe for ferric ion and a preparation method thereof. The probe can be used for the determination of ferric ion in the whole water system. Background technique [0002] Iron ion is one of the ions necessary for living organisms. It plays the role of transporting and storing oxygen in the body, and has extremely important physiological significance. On the other hand, although iron is an essential element for the body, excessive iron in the human body will produce excessive oxygen free radicals, which will cause damage to the body. Therefore, the development of Fe with excellent performance 3+ Fluorescent probes are necessary for real-time and online dynamic detection of Fe in organisms or environments. 3+ content and distribution. At present, most of the iron ion fluorescent probes have poor water solubility and need to add a ce...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D491/107G01N21/64C08G65/48
CPCC07D491/107C08G65/48G01N21/643G01N21/6486
Inventor 祁秀秀陈文华陈柏刘巧云李耀中刘文斌
Owner CHANGZHOU VOCATIONAL INST OF ENG