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High-bioavailability lycopene oral liquid product and preparing method

A technology of lycopene and availability, which is applied in the field of high bioavailability lycopene oral liquid products and preparation fields, can solve problems such as major safety risks and safety doubts, and achieves high bioavailability, stable quality and simple preparation process. Effect

Inactive Publication Date: 2016-12-14
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And when the particle size of food ingredients is less than 100nm, the chance of its entry and exit into human cells is greatly increased, and there may be a greater safety risk (Liu Jun, "Nano Food" Safety Doubts, Guangzhou Daily, September 30, 2010, Edition 033)

Method used

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  • High-bioavailability lycopene oral liquid product and preparing method
  • High-bioavailability lycopene oral liquid product and preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] (1) At 75°C, preheat 100mL of Tween80 aqueous solution with a mass percentage of 1% to obtain liquid A;

[0030] (2) Add 2g of glyceryl monostearate, 100mg of lycopene, and 1g of glyceryl caprylate into a light-proof container, protect with nitrogen, stir and heat (120°C, 2min) to obtain liquid B;

[0031] (3) Under room temperature and vigorous stirring, quickly add liquid A to liquid B, and continue stirring for 2 minutes;

[0032] (4) The mixed solution of step (3) is subjected to high-speed shear emulsification (10000r / min, 1.5min) to obtain a pre-emulsion;

[0033] (5) The pre-emulsion obtained in step (4) is homogenized under high pressure (30MPa, 3 cycles) to obtain lycopene emulsion;

[0034] (6) Rapidly cool the lycopene emulsion obtained in step (5) in a water bath at a temperature of 4° C. to obtain a lycopene oral liquid, wherein the lycopene content is 8.2 mg / 10 mL, and the cis configuration The proportion of lycopene to the total amount of lycopene is 50...

Embodiment 2

[0036] (1) At 75°C, preheat 100mL of Tween80 aqueous solution with a mass percentage of 2% to obtain liquid A;

[0037] (2) Add 5g of glyceryl monobehenate, 250mg of lycopene, and 2g of olive oil into a light-proof container, protect with nitrogen, stir and heat (140°C, 1min) to obtain liquid B;

[0038] (3) Under room temperature and vigorous stirring, quickly add liquid A to liquid B, and continue stirring for 2 minutes;

[0039] (4) The mixed solution of step (3) is subjected to high-speed shear emulsification (16000r / min, 2.5min) to obtain a pre-emulsion;

[0040](5) The pre-emulsion obtained in step (4) is subjected to high-pressure homogenization (50MPa, 3 cycles) to obtain lycopene emulsion;

[0041] (6) Rapidly cool the lycopene emulsion obtained in step (5) in a water bath at a temperature of 4°C to obtain a lycopene oral liquid, wherein the lycopene content is 20.1mg / 10mL, and the cis configuration Lycopene accounts for 52.62% of the total lycopene, and the average...

Embodiment 3

[0043] (1) At 75°C, preheat 100 mL of Tween80 aqueous solution with a mass percentage of 1.5% to obtain liquid A;

[0044] (2) Add 3g of glyceryl monostearate, 200mg of lycopene, and 1.5g of soybean oil into a light-proof container, protect with nitrogen, stir and heat (130°C, 1.5min) to obtain liquid B;

[0045] (3) Under room temperature and vigorous stirring, quickly add liquid A to liquid B, and continue stirring for 2 minutes;

[0046] (4) The mixed solution of step (3) is subjected to high-speed shear emulsification (16000r / min, 2.5min) to obtain a pre-emulsion;

[0047] (5) The pre-emulsion obtained in step (4) is subjected to high-pressure homogenization (40MPa, 3 cycles) to obtain lycopene emulsion;

[0048] (6) Rapidly cool the lycopene emulsion obtained in step (5) in a water bath at a temperature of 4°C to obtain a lycopene oral liquid, wherein the lycopene content is 16.5mg / 10mL, and the cis configuration Lycopene accounts for 49.85% of the total lycopene, and t...

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Abstract

The invention discloses a high-bioavailability lycopene oral liquid product and a preparing method. The solubility of lycopene in an oil-phase material is improved with a nitrogen protection method and a high-temperature thermal solution method, conversion of full-trans-lycopene into cis-configuration lycopene is promoted, then the ratio of the cis-configuration lycopene is increased, and the lycopene oral liquid product is prepared, wherein according to the lycopene oral liquid product, the particle size of prepared lycopene lipid particles ranges from 100 nm to 300 nm, the content of the lycopene is 8 mg / 10 mL to 22 mg / 10 mL, the ratio of the cis-configuration lycopene in the total amount of the lycopene is 50% or above, and the bioavailability is three or more times that of common lycopene products. The high-bioavailability lycopene oral liquid product has the advantages that the content of the lycopene is high, the ratio of cis-lycopene isomer is high, the bioavailability of the lycopene is high, the particle size of lipid microspheres is small, and the quality of the oral liquid product is stable.

Description

technical field [0001] The invention relates to a lycopene oral liquid product with high bioavailability and a preparation method thereof, which is characterized in that the particle size range of lycopene lipid particles in the product is 100-300nm, and the lycopene content is 8-22mg / 10mL , the cis-configuration lycopene accounts for more than 50% of the total lycopene, and the bioavailability of lycopene is more than 3 times that of ordinary lycopene products; the bioavailability of each lycopene oral solution (10mL) The availability is equivalent to soft capsules or compressed tablets containing 24-66 mg of lycopene. The invention belongs to the technical field of health food production. Background technique [0002] Lycopene is a carotenoid with various physiological functions such as anti-oxidation, enhancing human immunity, and helping to relieve symptoms of benign prostatic hyperplasia. It is widely used in health food, cosmetics and other fields. Since the lycopene...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/115A23L33/105
CPCA23V2002/00A23V2200/30A23V2250/213A23V2250/192A23V2250/194
Inventor 张连富孙清瑞刘会晓孟庆然
Owner JIANGNAN UNIV
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