Novel low-cross-pollution full-automatic biochemical analyzer

A biochemical analyzer, cross-contamination technology, applied in the field of medical equipment, can solve the problems of affecting the detection results, cross-contamination instrument performance of automatic biochemical analyzers, detection errors, etc., to achieve simple instrument structure, eliminate cross-contamination, and reduce failure rates Effect

Active Publication Date: 2016-12-14
SINNOWA MEDICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

One of the very common main problems in the use of existing full-automatic biochemical analyzers is that the existing full-automatic biochemical analyzers often need to use a variety of different reagents and detect different (concentration) samples in the detection work, and the instrument A common reagent needle is used to absorb different reagents and add them to each test cup for measurement. When drawing reagents, the inside and outside of the reagent needle, especially the reagent residue inside the needle often needs to use a lot of water, and even needs to be cleaned with a cleaning agent. Otherwise, residual The reagent will pollute the next inhaled reagent, which will affect the correctness of the test result
And some reagents may not be able to completely clean the inner and outer walls of the needle even though they use a large amount of water or even use cleaning agents at the same time.
In addition, there is also a design that uses a disposable tip to absorb samples or reagents. However, since a used tip needs to be discarded each time, a large space is needed to store the disposable tip to ensure that the instrument does not require operators to be on duty for a long time, and The instrument designed in this way produces more consumables during operation
In addition, the biochemical analyzer also needs to stir and mix the reactants (reagent and sample mixture) in the detection cup during detection to obtain good detection results. However, the stirring devices of the existing fully automatic biochemical analyzers mainly use shared The method of stirring needles that need to contact the reaction liquid, and because the stirring needles need to be stirred by contacting the reaction liquids of different reagents and samples, there must be cross-contamination
In addition, there is also non-contact stirring using ultrasonic waves, but the cost of the instrument is increased due to the complexity of the ultrasonic device, and the ultrasonic waves also cause cumulative damage to the instrument components such as the test cup and interfere with the detection signal of the instrument while stirring the liquid in the test cup. risk, so this technique is rarely used
In order to eliminate cross-contamination of reagent needles and stirring needles, the existing automatic biochemical analyzers generally use cleaning agents and a large amount of water to clean the reagent needles and stirring needles, so the instrument consumes a lot of water, but unfortunately, despite the Washing with a large amount of water sometimes cannot completely eliminate cross-contamination, and detection errors caused by cross-contamination occur from time to time
Cross-contamination of automatic biochemical analyzers is the main obstacle and bottleneck for instrument performance improvement

Method used

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  • Novel low-cross-pollution full-automatic biochemical analyzer
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  • Novel low-cross-pollution full-automatic biochemical analyzer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Such as Figure 1a , Figure 2a and Figure 3a Including: 2A: Reagent plate; 2B: Reagent bottle; 2C: Reagent needle holder; 2D; Sample; 2E: Moving arm of reagent needle moving device: 2F: Sample needle cleaning pool; 2G: Sample needle arm; R1: Reagent 1 plate ; R2: Reagent 2 trays; 2H: Detection cup and detection cup position; 2I: Reaction tray; 2J: Detection cup cleaning device. 3A: Reagent needle; 3D: Tubing between reagent aspiration syringe and reagent needle end connector; 3E: Reagent aspiration syringe; 3J: Pressure detector.

[0046] The main structure of the instrument includes an instrument control unit, a reaction plate unit (including a reaction plate 2I and multiple detection cups 2H on the reaction plate), an optical detection unit (including: a light source 4A, a monochromator 4B, and an optical signal detector 4C), a detection Cup cleaning unit 2J, non-intersecting reagent unit (comprising reagent disc 2A, a plurality of reagent bottles 2B loaded on the...

Embodiment 2

[0070] The difference between embodiment 2 and embodiment 1 is that this embodiment does not adopt the non-intersecting reagent unit designed by the present invention, but uses the existing common reagent plate and reagent needle structure, and adopts the non-contact type reagent unit designed by the present invention in addition. The uneven air pressure stirring unit is used to stir the reactants in the detection cup. An air pressure stirring needle 7M is respectively provided at positions RC3 and RC5 of the instrument reaction discs for stirring the reactants in the detection cup. The way it is stirred is as Figure 7a and 7b and 7c and 7d are shown. Figure 7a The medium air pressure stirring needle pressurizes and injects gas to one side of the liquid in the detection cup, causing the pressurized liquid in the detection cup to move downward and to the other side; Figure 7b It shows that when the air pressure stirring needle stops spraying and pressurizing into the dete...

Embodiment 3

[0076] The embodiment of a new type of fully automatic biochemical analyzer with low cross-contamination designed in this embodiment: the instrument has a non-cross-type reagent unit (comprising a plurality of reagent bottles loaded on the reagent tray, the reagent tray, and each reagent bottle respectively) at the same time. Equipped with independent reagent needle brackets and reusable reagent needles equipped on each bracket, a common reagent suction syringe and a common reagent needle connector connected by pipelines, reagent needle moving devices, etc.) and non-contact Type uneven air pressure stirring unit (its composition includes: air pump, pipeline, air pressure stirring needle, etc., and the unit can also include one of flow adjustment / switching device, air flow constant pressure device, gas heating and constant temperature device, etc. composed of several or all components). When the instrument is running, the non-crossing reagent unit is used to distribute the reag...

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Abstract

The invention provides a novel low-cross-pollution full-automatic biochemical analyzer which includes a reaction disk unit. The reaction disk unit includes a reaction disk, on which a group of detection cups are placed. A non-contacted non-uniform air pressure stirring unit is arranged on the reaction disk and includes an air pressure stirring needle tip and a power supply system, the air pressure stirring needle tip connected to the power supply system through a pipeline. The air pressure stirring unit includes, successively, an air inlet, an air filter, an air pump, an air storage tank, an air flow pressure regulating switch, an air supply pipe and finally the air pressure stirring needle tip. An air heating machine temperature control device is arranged on the lower end of the air storage tank. The analyzer also includes a non-cross-type reagent unit, which comprises a reagent needle moving apparatus, a reagent disk, and a reagent needle bracket. The reagent disk includes a group of reagent bottles. A plurality of reagent needle positions are arranged on the reagent needle bracket. The number of the reagent needle positions on the reagent needle bracket is equal to the number of the reagent bottles, wherein each reagent needle is used for sucking only one corresponding reagent.

Description

technical field [0001] The invention relates to the field of medical equipment, in particular to a novel fully automatic biochemical analyzer with low cross-contamination. Background technique [0002] Biochemical analyzers are commonly used testing equipment in medical institutions. One of the very common main problems in the use of existing full-automatic biochemical analyzers is that the existing full-automatic biochemical analyzers often need to use a variety of different reagents and detect different (concentration) samples in the detection work, and the instrument A common reagent needle is used to absorb different reagents and add them to each test cup for measurement. When drawing reagents, the inside and outside of the reagent needle, especially the reagent residue inside the needle often needs to use a lot of water, and even needs to be cleaned with a cleaning agent. Otherwise, residual The reagent will pollute the next inhaled reagent, which will affect the corre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N35/02
CPCG01N35/025G01N2035/00544
Inventor 徐新周强张陆军缪建潘有铭宋成桥纪本奎魏炜王金香
Owner SINNOWA MEDICAL SCI & TECH
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