Corneal graft cascade method for improving tissue engineering artificial cornea diopter

A technology of artificial cornea and tissue engineering, which is applied in tissue regeneration, pharmaceutical formulation, additive processing, etc., and can solve the problems of insufficient refractive power of artificial cornea

Active Publication Date: 2016-12-21
广州尤尼智康生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The invention relates to a corneal grafting cascading method for improving the diopter of a tissue-engineered artificial cornea, and solves the technical problem of insufficient diopter of a single tissue-engineered artificial cornea

Method used

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  • Corneal graft cascade method for improving tissue engineering artificial cornea diopter
  • Corneal graft cascade method for improving tissue engineering artificial cornea diopter
  • Corneal graft cascade method for improving tissue engineering artificial cornea diopter

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preparation example Construction

[0028] 1. The preparation method of the front end corneal graft is:

[0029] 1) Preparation of three-dimensional corneal stents using multi-component copolymers as raw materials: using a 3D bioprinter, place the multi-component copolymers in the barrel of the printer, one printing requires 8-12g of raw materials, and extrude the multi-component copolymer materials according to the preset model On a printing platform loaded with a sterilized glass bottom plate, a three-dimensional scaffold in the shape of the cornea was printed.

[0030] With reference to the average parameters of the human corneal structure, the design parameters of the three-dimensional corneal graft stent in this embodiment are as follows: the curvature radius of the outer wall of the three-dimensional stent is 7.7 mm, the curvature radius of the inner wall is 6.7 mm, and the wall thickness is 200-400 μm. The diameter of the corneal graft is 12mm.

[0031] The diameter of the print head is 200μm, the extrus...

Embodiment 1

[0053] Prepare the anterior corneal graft as follows:

[0054] (1) Synthesis of ternary copolymer materials: Take 40% of ε-caprolactone monomer, 40% of lactide monomer and 20% of collagen monomer as raw materials in the reaction equipment according to the mass percentage, and add all Put in 0.5% zinc octoate as a catalyst, vacuumize, fill with nitrogen, and react in a closed polymerization equipment at 160°C for 24 hours to obtain a multi-component copolymer with a molecular weight of 32838.

[0055] (2) Print three-dimensional corneal scaffolds: using the above-mentioned ternary copolymer materials as raw materials, use a 3D bioprinter to construct a three-dimensional structure in the shape of a human cornea. The radius of curvature of the inner wall is 6.7 mm, the wall thickness is 300 μm, and the diameter is 12 mm. A three-dimensional corneal scaffold capable of loading cells is obtained. The diameter of the print head is 200 μm, the extrusion speed is 0.033 mm / s, the prin...

Embodiment 2

[0063] Prepare the posterior corneal graft in the following steps, the steps are:

[0064] 1. Carry out an eye examination on the patient, collect eye data, and calculate the degree of correction of the posterior corneal graft.

[0065] The simplified formula for calculating the corneal curvature that needs to be selected is as follows:

[0066] (horizontal curvature + vertical curvature) / 2*110% = corneal curvature to be selected

[0067] For example: the horizontal curvature is 7.8, the vertical curvature is 7.5, the base arc of the required lens is: (7.8+7.5) / 2*110%=8.4

[0068] 2. 3D printing posterior corneal graft.

[0069] 1) Establish a three-dimensional model of the posterior corneal graft. Both the front and rear walls of the optical part use convex lenses. The diopter of the glasses is adjusted to the three-dimensional model according to the patient's needs, and then the model files are processed in layers. Posterior corneal grafts can be designed as image 3 I...

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Abstract

The invention discloses a corneal graft cascade method for improving the tissue engineering artificial cornea diopter. A tissue engineering artificial corneal graft is manufactured by polymeric biomaterials through 3D (three-dimensional) printing; the corneal graft comprises a front end corneal graft and a back end corneal graft; the front end corneal graft has the similar dimension and curvature to those of the patient cornea, and is put on a corneal recipient bed; the back end corneal graft has the similar dimension and curvature to those of a crystalline lens of a patient, and is put between the iris and the crystalline lens of the patient; by combining the diopter of the front end corneal graft, the front wall and back wall curvature in the back end corneal graft is regulated; the integral diopter is improved to the normal value; the corneal graft cascade is realized; the technical problem of insufficient single tissue engineering artificial cornea diopter is solved.

Description

technical field [0001] The invention belongs to the technical field of implanted medical devices for human body, and in particular relates to a corneal graft cascading method for improving the diopter of tissue engineering artificial cornea. Background technique [0002] Corneal blindness is the second most common blindness after cataract, and the vast majority of patients can regain their sight through corneal transplantation. At present, the treatment methods for corneal blindness mainly include surgical transplantation of donated cornea, artificial corneal transplantation and so on. However, due to various factors, the sources of corneas in eye banks across my country are extremely scarce, and many patients can only passively wait for donations. Research on artificial corneas has been developed abroad with heterogeneous materials such as polyhydroxyethyl methacrylate (PHEMA), polymethyl methacrylate (PMMA), glass, silica gel, etc., but there are biological Poor compatib...

Claims

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Application Information

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IPC IPC(8): A61F2/14B33Y10/00A61L27/24A61L27/18A61L27/36
CPCA61F2/142A61F2240/002A61L27/18A61L27/24A61L27/3633A61L2400/18A61L2430/16B33Y10/00C08L67/04
Inventor 王红陈静施敏超
Owner 广州尤尼智康生物科技有限公司
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