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Temperature-responsive core-shell magnetic hydrogel nanoparticles and preparation method thereof

A temperature-responsive, magnetic nanoparticle technology, which can be used in medical preparations without active ingredients, medical preparations containing active ingredients, and materials for wave energy or particle radiation treatment, and can solve problems such as inability to prepare magnetic gel particles , to achieve the effect of mild and simple adsorption process

Active Publication Date: 2019-10-11
FOSHAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method cannot prepare nano-scale magnetic gel particles.

Method used

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  • Temperature-responsive core-shell magnetic hydrogel nanoparticles and preparation method thereof
  • Temperature-responsive core-shell magnetic hydrogel nanoparticles and preparation method thereof
  • Temperature-responsive core-shell magnetic hydrogel nanoparticles and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0043] A temperature-responsive core-shell magnetic hydrogel nanoparticle comprising the following steps (the parts are parts by mass):

[0044] (1) Put 10 parts of P(GMA-N 3 ) (the degree of polymerization is 2000), 20 parts of P(NIPAAm-co-GMA)-C≡CH (the degree of polymerization is 2000, the molar ratio of crosslinking point monomer and temperature responsive monomer is 1:1000), 5 parts of DOPA- C≡CH was co-dissolved in 40 parts of dimethyl sulfoxide, adding 0.05 parts of PMDETA / CuCl, wherein the mass ratio of the two was 1:1, bubbling inert gas for 10 minutes, and then stirring and reacting at 35°C for 6 hours, using Dialysis technology, the reaction solution is dialyzed for 72 hours, and then freeze-dried to obtain a binary functional graft copolymer.

[0045] (2) Dissolve and disperse 60 parts of binary functional graft copolymers and 10 parts of magnetic nanoparticles in 10 parts of methylene chloride, stir at room temperature for 20 minutes, remove methylene chloride by...

Embodiment 2

[0049] A temperature-responsive core-shell magnetic hydrogel nanoparticle comprising the following steps (the parts are parts by mass):

[0050] (1) Put 10 parts of P(GMA-N 3 ) (the degree of polymerization is 3000), 20 parts of P(NIPAAm-co-GMA)-C≡CH (the degree of polymerization is 6000, the molar ratio of crosslinking point monomer and temperature responsive monomer is 4:1000), 5 parts of DOPA- C≡CH was co-dissolved in 60 parts of dimethyl sulfoxide, adding 0.05 parts of PMDETA / CuCl, wherein the mass ratio of the two was 2:1, bubbling inert gas for 20 minutes, and then stirring and reacting at 35°C for 12 hours, using In the dialysis technique, the reaction solution is dialyzed for 66 hours, and then freeze-dried to obtain a binary functional graft copolymer.

[0051] (2) Dissolve and disperse 60 parts of binary functional graft copolymers and 10 parts of magnetic nanoparticles in 10 parts of methylene chloride, stir at room temperature for 20 minutes, remove methylene chlo...

Embodiment 3

[0055] A temperature-responsive core-shell magnetic hydrogel nanoparticle comprising the following steps (the parts are parts by mass):

[0056] (1) Put 10 parts of P(GMA-N 3 ) (the degree of polymerization is 4000), 20 parts of P(NIPAAm-co-GMA)-C≡CH (the degree of polymerization is 10000, the molar ratio of crosslinking point monomer and temperature responsive monomer is 8:1000), 6 parts of DOPA- C≡CH was co-dissolved in 60 parts of dimethyl sulfoxide, adding 0.1 part of PMDETA / CuCl, wherein the mass ratio of the two was 3:1, bubbling inert gas for 20 minutes, and then stirring and reacting at 45°C for 24 hours, using In the dialysis technique, the reaction solution is dialyzed for 60 hours, and then freeze-dried to obtain a binary functional graft copolymer.

[0057] (2) Dissolve and disperse 70 parts of binary functional graft copolymers and 20 parts of magnetic nanoparticles in 20 parts of chloroform, stir at room temperature for 40 minutes, remove chloroform by rotary ev...

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Abstract

The invention particularly relates to a preparation method of core-shell structure magnetic hydrogel nanoparticles with temperature responsiveness. Firstly, a binary functional grafted copolymer containing an efficient adsorption unit and a temperature-responsive unit containing cross-linking points is synthesized; then, the efficient adsorption unit in the copolymer is utilized for adsorbing copolymer molecules on the surfaces of magnetic nanoparticles; a cross-linking agent is introduced, the molecular structure of the temperature-responsive unit is locked, and a gel layer is formed. The defects that an existing method of constructing a hydrogel layer on the surfaces of magnetic nanoparticles is complex in step and poor in controllability, and the stability of the magnetic nanoparticles is influenced are overcome, and the preparation method has the advantages that the adsorption efficiency of the copolymer on the surfaces of the magnetic nanoparticles is high; the negative influence on the magnetic nanoparticles in the adsorption process is small; the magnetic nanoparticles are wrapped comprehensively; the gel layer structure is adjustable; the circulating performance of the hydrogel layer is stable.

Description

technical field [0001] The invention belongs to the technical field of organic / inorganic composite functional materials, and in particular relates to a temperature-responsive core-shell magnetic hydrogel nanoparticle and a preparation method thereof. Background technique [0002] Hydrogel is a soft polymer material with a three-dimensional structure and the ability to absorb water and swell. According to different application environments or uses, its chemical properties, mechanical properties, and biocompatibility can all be adjusted as needed. Hydrogels have great application prospects in the fields of biological tissue engineering and drug release. Hydrogel can be used as a biomimetic material to simulate non-vascular tissues such as skin and cartilage in vivo; it can also be used as a carrier to absorb and release drug molecules through the holes and channels inside the gel. [0003] Temperature-responsive hydrogels are a class of smart materials that can adjust their ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/30A61K41/00A61K9/06A61K47/32C08G81/02
Inventor 苗磊
Owner FOSHAN UNIVERSITY
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