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Detection method on basis of taking epidermal keratin and associated protein thereof as biomarkers for predication and detection of ultraviolet injuries and application of detection method

A biomarker and related protein technology is applied in the fields of application, spectrum diagnosis, and light diagnosis. It can solve the problems of no application, no direct damage detection, and no guiding significance for early detection and prevention of skin diseases. The effect of popularization

Inactive Publication Date: 2017-01-04
JIANGSU KUNHUI BIOTECH CO LTD
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Problems solved by technology

Therefore, such instruments have poor clarity and sensitivity, cannot detect early skin damage caused by ultraviolet rays, have no guiding significance for early detection and prevention of skin damage and further skin diseases, and have almost no clinical application
In particular, for dermatology clinics, it is often only possible to make a qualitative assessment of the skin's UV sensitivity using a phototest, in which UV light is irradiated on a non-lighted skin area, such as a patch of skin on the back, and then passed The area of ​​erythema that appears on this skin is used to evaluate the patient's skin UV sensitivity, which is neither accurate nor a direct detection of damage.

Method used

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  • Detection method on basis of taking epidermal keratin and associated protein thereof as biomarkers for predication and detection of ultraviolet injuries and application of detection method
  • Detection method on basis of taking epidermal keratin and associated protein thereof as biomarkers for predication and detection of ultraviolet injuries and application of detection method
  • Detection method on basis of taking epidermal keratin and associated protein thereof as biomarkers for predication and detection of ultraviolet injuries and application of detection method

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Embodiment Construction

[0022] The present invention will be further illustrated by specific description below.

[0023] Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

[0024] The inventor has conducted a large number of experiments to determine the relationship between the degree of change in the structure and content of keratin and keratin-related proteins after ultraviolet-induced skin damage and the degree of skin damage.

[0025] According to the present invention, using male C57 mice, the weight of UVC and irradiated mice is in the range of 15-25 g, and the weight of UVB / UVA irradiated mice is in the range of 18-25 g. After the UV radiation was completed, the mice were housed in the animal room at 22-24°C with a 12-hour light / dark cycle, and had free access to food and water.

[0026] UV-irradiated skin was imaged non-invasively using confocal laser micro...

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Abstract

The invention provides a detection method on the basis of taking epidermal keratin and associated protein thereof as biomarkers for predication and detection of ultraviolet injuries and application of the detection method. According to the method, predication and detection of the ultraviolet injuries are realized on the basis of detecting changes of keratin and associated protein thereof. After skin is exposed to ultraviolet irradiation, structures and contents of the epidermal keratin and the associated protein have changes which are positively associated with skin injuries.

Description

technical field [0001] The present invention relates to the prediction and detection of biomarkers for ultraviolet light-induced skin damage, specifically based on the detection of changes in keratin and keratin-related proteins in the epidermis, as a detection method for predicting and detecting ultraviolet light-induced skin damage biomarkers and its application . Background technique [0002] Ultraviolet rays in the sun are the main reason why human skin is damaged by ultraviolet radiation. Ultraviolet radiation will cause various pathological effects on the skin, such as skin redness, peeling, inflammation, ulceration, and various skin diseases, etc., and will produce a large amount of active oxidation substances, causing DNA damage to subcutaneous cells and accelerating skin aging. In fact, 90% of human skin aging is due to ultraviolet radiation, and the most serious disease induced by ultraviolet radiation is skin cancer. Studies have proved that more than 90% of skin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00
CPCA61B5/445A61B5/0059A61B5/0071A61B5/0075
Inventor 殷卫海张铭超贺号
Owner JIANGSU KUNHUI BIOTECH CO LTD
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