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Preparation method of ferrous sulfate skeleton type sustained-release dropping pills

A technology of ferrous sulfate and sustained-release dropping pills, which is applied in the fields of pill delivery, pharmaceutical formulations, extracellular fluid diseases, etc. and other problems, to achieve the effect of improving patient compliance, good drug release effect, and simple calculation.

Active Publication Date: 2019-07-19
GUANGXI UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] At present, there is no dosage form of ferrous sulfate skeleton sustained-release dripping pills produced at home and abroad, and there is no precedent for optimizing its process by response surface methodology.

Method used

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  • Preparation method of ferrous sulfate skeleton type sustained-release dropping pills
  • Preparation method of ferrous sulfate skeleton type sustained-release dropping pills
  • Preparation method of ferrous sulfate skeleton type sustained-release dropping pills

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] A preparation method of a ferrous sulfate skeleton type sustained-release dropping pill, which comprises the following steps: weighing a matrix and drug ferrous sulfate in a weight ratio of 2:1, heating and melting the matrix in a water bath, and then adding ferrous sulfate to the matrix , stirring and dissolving to obtain the liquid medicine, the temperature of the liquid medicine is kept at 70°C, and then the liquid medicine is dripped into the condensate at a drop distance of 2cm and a drop speed of 10 drops / min, and the temperature of the lower half of the condensate is 0°C , into a pellet, take it out after standing, wipe off the condensate, and dry it to get the product; the matrix is ​​a mixture of polyethylene glycol and glyceryl monostearate, and the weight ratio of the mixture of polyethylene glycol and glyceryl monostearate is 3:1, the polyethylene glycol mixture consists of PEG4000 and PEG6000, the weight ratio of PEG6000 and PEG4000 is 2:1.

Embodiment 2

[0076] A preparation method of ferrous sulfate skeleton type sustained-release dripping pills, which comprises the following steps: weighing a matrix and drug ferrous sulfate in a weight ratio of 4:1, heating and melting the matrix in a water bath, and then adding ferrous sulfate to the matrix , stirring and dissolving to obtain the liquid medicine. The temperature of the liquid medicine is kept at 85°C, and then the liquid medicine is dripped into the condensate at a drop distance of 6cm and a drop speed of 30 drops / min. The temperature of the lower half of the condensate is 5°C. Form a pellet, take it out after standing, wipe off the condensate, and dry it to get the product; the matrix is ​​a mixture of polyethylene glycol and glyceryl monostearate, and the weight ratio of the mixture of polyethylene glycol and glyceryl monostearate is 5 :1, the polyethylene glycol mixture is composed of PEG4000 and PEG6000, and the weight ratio of PEG6000 and PEG4000 is 4:1.

Embodiment 3

[0078] A preparation method of ferrous sulfate skeleton type sustained-release dripping pills, which comprises the following steps: weighing base and drug ferrous sulfate in a weight ratio of 6:1, heating and melting the base in a water bath, and then adding ferrous sulfate into the base , stirring and dissolving to obtain the liquid medicine. The temperature of the liquid medicine is kept at 90°C, and then the liquid is drawn into the condensate at a drop distance of 10cm and a drop speed of 50 drops / min. The temperature of the lower half of the condensate is 20°C. Form a pellet, take it out after standing, wipe off the condensate, and dry it to get the product; the matrix is ​​a mixture of polyethylene glycol and glyceryl monostearate, and the weight ratio of the mixture of polyethylene glycol and glyceryl monostearate is 7 :1, the polyethylene glycol mixture is composed of PEG4000 and PEG6000, and the weight ratio of PEG6000 and PEG4000 is 6:1.

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Abstract

The invention discloses a preparation method of a ferrous sulfate skeleton type slow-release dripping pill, which comprises the following steps: weighing a matrix and drug ferrous sulfate in a weight ratio of 2:1 to 6:1, heating and melting the matrix in a water bath, and then Add ferrous sulfate into the matrix, stir and dissolve to obtain a medicinal solution, keep the temperature of the medicinal solution at 70°C-90°C, then absorb the medicinal solution at a drop distance of 2-10cm, and drop in at a rate of 10-50 drops / min In the condensate, the temperature of the lower half of the condensate is 0-20°C, and it is formed into pellets, taken out after standing, wiped off the condensate, and dried to obtain it; the ferrous sulfate skeleton type slow-release dropping pill of the present invention can release cumulatively in vitro The degree conforms to the Higuchi kinetic equation, and the slow-release effect of the drug is good; it can increase the absorption of the drug in the human body, achieve the purpose of long-acting and high-efficiency, and improve the bioavailability, reduce the number of times and doses of taking, and avoid the phenomenon of peak and valley plasma concentration , reduce toxic and side effects, improve patient compliance, and can be widely used clinically.

Description

technical field [0001] The invention belongs to the field of medicine preparation, and in particular relates to a preparation method of a ferrous sulfate skeleton type sustained-release dripping pill. Background technique [0002] The most common anemia in our country is iron deficiency anemia, because iron is an indispensable raw material for the formation of hemoglobin (ie hemoglobin), if the supply of iron is not kept up, the hemoglobin will drop, resulting in anemia in the human body. The harm of iron deficiency anemia to the three major systems of the body: the first is the harm of human iron deficiency anemia to the cardiovascular system. The more serious anemia, that is, if the hemoglobin is lower than 7 g / dl, the heart rate will be accelerated and the heart will be enlarged. What’s more, you can hear all kinds of murmurs during systole; the second is the harm of iron deficiency anemia to the digestive system, that is, contraction of the papilla of the tongue, weakene...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/22A61K33/26A61P7/06
CPCA61K9/0002A61K9/2031A61K33/26
Inventor 韦媛媛陈晓伟梁茜莹郭莎莎
Owner GUANGXI UNIVERSITY OF TECHNOLOGY
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