Preparation method of ferrous sulfate coated sustained-release dropping pills

A technology of ferrous sulfate and sustained-release dropping pills, applied in sugar-coated pills, pill delivery, pharmaceutical formulations, etc., can solve the problem of not producing ferrous sulfate-coated sustained-release dropping pills, etc., and avoid the peak and valley phenomenon of blood drug concentration , good reproducibility, and the effect of reducing the number of doses and doses

Active Publication Date: 2019-08-02
GUANGXI UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, there is no such dosage form of ferrous sulfate-coated sustained-release dropping pills produced at home and abroad, and there are almost no relevant reports.

Method used

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  • Preparation method of ferrous sulfate coated sustained-release dropping pills
  • Preparation method of ferrous sulfate coated sustained-release dropping pills
  • Preparation method of ferrous sulfate coated sustained-release dropping pills

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] A preparation method for ferrous sulfate coated sustained-release dropping pills, which comprises the following steps:

[0052] (1) Preparation of pellet core: Weigh PEG6000 and ferrous sulfate in a weight ratio of 2:1, heat and melt PEG6000 in a water bath, then add ferrous sulfate to PEG6000 in stages, stir and dissolve to obtain a medicinal solution, the temperature of the medicinal solution is Keep it at 75°C, then absorb the medicinal solution and drop it into the condensate at a drop distance of 3cm, form a pellet, take it out after standing for half an hour, wipe off the condensate, and dry it; the condensate is paraffin. The dripping speed of the liquid medicine is 20 drops / min, and the temperature of the lower half of the condensate is 5°C.

[0053] (2) Preparation of slow-release coating solution: Weigh the film-forming agent with a mass concentration of 1%, the plasticizer of 0.4%, and the pore-forming agent of 0.05%, and replenish to 100% by the solvent, and...

Embodiment 2

[0056] A preparation method for ferrous sulfate coated sustained-release dropping pills, which comprises the following steps:

[0057] (1) Preparation of pellet core: Weigh PEG6000 and ferrous sulfate in a weight ratio of 4:1, heat and melt PEG6000 in a water bath, then add ferrous sulfate to PEG6000 in batches, stir and dissolve to obtain a medicinal solution, and the temperature of the medicinal solution is Keep it at 80°C, then absorb the medicinal solution and drip it into the condensate at a drop distance of 5cm, form a pellet, take it out after standing for half an hour, wipe off the condensate, and dry it; the condensate is paraffin. The dripping speed of the liquid medicine is 20 drops / min, and the temperature of the lower half of the condensate is 5°C.

[0058] (2) Preparation of slow-release coating solution: Weigh the film-forming agent, 0.6% plasticizer, and 0.15% pore-forming agent with a mass concentration of 3%, then replenish to 100% by solvent, add the film-fo...

Embodiment 3

[0061] A preparation method for ferrous sulfate coated sustained-release dropping pills, which comprises the following steps:

[0062] (1) Preparation of pellet core: Weigh PEG6000 and ferrous sulfate in a weight ratio of 3:1, heat and melt PEG6000 in a water bath, then add ferrous sulfate to PEG6000 in stages, stir and dissolve to obtain a medicinal solution, the temperature of the medicinal solution is Keep it at 85°C, then absorb the medicinal solution and drop it into the condensate at a drop distance of 7cm, form a pellet, take it out after standing for half an hour, wipe off the condensate, and dry it; the condensate is paraffin. The dripping speed of the liquid medicine is 20 drops / min, and the temperature of the lower half of the condensate is 5°C.

[0063] (2) Preparation of slow-release coating solution: Weigh the film-forming agent with a mass concentration of 5%, the plasticizer of 0.8%, and the pore-forming agent of 0.25%, and then replenish to 100% by the solvent...

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PUM

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Abstract

The invention discloses a preparation method of a ferrous sulfate-coated slow-release dropping pill, which comprises the following steps: (1) preparation of a ball core; (2) preparation of a slow-release coating liquid; (3) coating. The ferrous sulfate sustained-release dropping pills of the present invention have a cumulative release in vitro conforming to the Higuchi kinetic equation, and the sustained-release effect of the drug is good; it can increase the drug absorption of the human body, achieve the purpose of long-acting and high-efficiency, and improve bioavailability, reduce The times and doses of administration avoid the occurrence of peak and valley phenomena of blood drug concentration, reduce toxic and side effects, improve patient compliance, and can be widely used clinically. The preparation process of the invention is easy to operate, has good reproducibility and reliability.

Description

technical field [0001] The invention belongs to the field of medicine preparation, and in particular relates to a preparation method of ferrous sulfate-coated sustained-release dripping pills. Background technique [0002] Iron is the fourth most abundant element in the earth's crust. In the 17th century, the existence of iron in the human body and various animals and plants has been discovered, and it has become one of the earliest discovered essential trace elements for the human body. Although the content is not high, people gradually realize that it can affect certain health and diseases, and have accumulated a lot of clinical experience. With the rapid development of medical technology, people have gradually realized that when the body's iron content and red blood cell distribution are abnormal, physiological functions will also be affected. Among the causes of anemia, the most common one is iron deficiency anemia, also known as nutritional anemia, and the patients wi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/22A61K33/26A61K9/36A61P7/06
CPCA61K9/0002A61K9/2031A61K9/2866A61K33/26
Inventor 韦媛媛陈晓伟陈梦云郭莎莎
Owner GUANGXI UNIVERSITY OF TECHNOLOGY
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