Semipermeable membrane layered bio-artificial liver online monitoring and constant-temperature heating integrated system

Abstract

The invention discloses a semipermeable membrane layered bio-artificial liver online monitoring and constant-temperature heating integrated system, which comprises a blood input port, a blood pump, an arterial kettle, a semipermeable membrane layered integrated bioreactor, an intravenous kettle and a blood return port which are sequentially connected; the semipermeable membrane layered integrated bioreactor comprises a cavity, a plasma separator which is arranged at one side of the cavity and a bio-reactor body which is arranged at the other side of the cavity; the plasma separator and the bio-reactor body are spaced by virtue of a spacing semipermeable membrane; and multiple layers of filtering semipermeable membranes are horizontally arranged in the bio-reactor body. The integrated system disclosed by the invention has the beneficial effects that the integrated system is simpler and more practical in design; cells and plasma get into full contact, which is conducive to improving an exchange efficiency of the two types of substances, and a plasma degrading effect is enhanced; a cell storage space is enlarged and a loading capacity is increased.

Description

technical field [0001] The invention belongs to the technical field of bioartificial liver, and in particular relates to an integrated system of on-line monitoring and constant temperature heating of a semipermeable membrane layered bioartificial liver. Background technique [0002] There are a huge number of patients with liver failure in my country, and finding new effective treatments for liver failure has become an urgent problem to be solved. The artificial liver system can maintain the patient's life, waiting for the opportunity of liver transplantation, or the opportunity of the patient's own liver recovery, which is a hot spot of research and development in the near future. The bioartificial liver support system mainly uses cell groups with liver metabolism function to purify the blood of patients with liver failure, realize the function of liver support in vitro, and win precious time for liver regeneration or waiting for liver transplantation, which has important c...

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Problems solved by technology

[0005] The purpose of the present invention is to overcome the problems of the existing bioartificial liver system, such as complex structure, cumbersome operation, limited volume of bioreactor corresponding to the system, small cell loading, limited exchange area between plasma and liver cells, uneven cell distribution, etc., and provide a Semi-permeable membrane layered bioartificial liver online monitoring and constant temperature heating integrated system, which has the characteristics of simple system, easy operation, increased cell loading, constant temperature heating, and improved material exchange efficiency and uniformity.

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