Chinese mugwort essential oil and preparation method and application thereof

An essential oil, supercritical technology, applied in the direction of essential oils/fragrance, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of high price, no large-scale clinical use, etc., and achieve low price, prevention and alleviation effects. , the effect of convenient use

Inactive Publication Date: 2017-01-04
苏州森佰生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

For example, the marketed Infliximab has not been used on a large scale in China due to its high price

Method used

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  • Chinese mugwort essential oil and preparation method and application thereof
  • Chinese mugwort essential oil and preparation method and application thereof
  • Chinese mugwort essential oil and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A kind of Artemisia argyi essential oil, its preparation method specifically comprises the following steps:

[0030] (1) Take 2 kg of Artemisia argyi leaves that were naturally dried during mid-June in Qichun, Hubei, pulverize them with a pulverizer, and put them into a supercritical extraction device;

[0031] (2) Heating in a water bath to make the supercritical extraction device reach a temperature of 38°C, and inject CO 2 , to replace the air in the system clean;

[0032] (3) Turn on the compressor, adjust the pressure in the supercritical extraction device to 15MPa, and adjust the outlet valve of the supercritical extraction device so that the CO 2 When the flow rate reaches a stable value of 22 kg / h, keep the system in this state for 60 minutes, open the separator, and obtain the crude product of essential oil;

[0033] (4) Add the crude product of the extracted essential oil into 2 times the volume of absolute ethanol, place it for 36 hours after stirring, and ...

Embodiment 2

[0036] The therapeutic effect of Artemisia argyi essential oil prepared in embodiment 1 on rat arthritis

[0037] 2.1 Animals and grouping: male Wistar rats, weighing 160-180g, the animal quality is qualified. They were raised in a second-level clean animal room, with 5 animals per cage, and were randomly selected for modeling after 7 days of adaptation. The groups are shown in Table 1.

[0038] Table 1 Grouping of experimental animals

[0039]

[0040] 2.2 Preparation of Type II Collagen Type II collagen was dissolved in 0.1mol / L acetic acid to make the final concentration 4mg / mL, and stirred overnight.

[0041] 2.3 Preparation of the model Add the stirred type II collagen acetic acid solution dropwise into cold Freund's complete adjuvant at a ratio of 1:1, and fully emulsify. Each rat was intradermally injected with a total of 0.25 mL of emulsion at 3 points on the sole of the left hind foot, the base of the tail, and the back. After 7 days, a booster injection was give...

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Abstract

The invention discloses Chinese mugwort essential oil and a preparation method and application of the Chinese mugwort essential oil. The preparation method comprises the following steps: taking Chinese mugwort leaves which are picked in Qichu, Hubei in mid June and naturally dried, grinding to be put in a supercritical extraction device; heating in water bath to make the supercritical extraction device reach the set temperature, and introducing CO2, and completely replacing air in the system; adjusting the pressure in the supercritical extraction device, and adjusting an outlet valve to make the flow rate of CO2 reach a required stable value, keeping the system in the state for 50 to 70 minutes to obtain an essential oil crude product; adding the extracted essential oil crude product to anhydrous ethanol, standing after stirring, carrying out vacuum filtration, removing precipitated wax compositions, and decompressing filtrates to recycle ethanol, so as to obtain the dewaxed Chinese mugwort essential oil. The Chinese mugwort essential oil disclosed by the invention is applied to prevention and mitigation of chronic inflammatory diseases, low in cost and obvious in curative effect on the prevention and mitigation of the chronic inflammatory diseases, and further develops a convenient use method of the Chinese mugwort essential oil.

Description

technical field [0001] The invention relates to the field of preparation and use methods of plant essential oils, in particular to a Artemisia argyi essential oil and its preparation method and application. Background technique [0002] Ai, a kind of wormwood, named after it is produced in Qizhou (formerly known as Qichun County), one of the "Four Treasures of Qichun" (Qizhu, Qiai, Qichun, Qichun) in Qichun County, Hubei Province , a specialty Chinese herbal medicine, a product of China's national geographical indication, both stems and leaves can be used as medicine. Artemisia argyi contains 17 known compounds, and its volatile oil content, total flavonoid content, and combustion calorific value are significantly better than those of Artemisia argyi leaves produced in other regions. Artemisia argyi oil has obvious anti-asthma, antitussive, expectorant and anti-inflammatory effects. Qiai is a famous and precious Chinese herbal medicine with a long history and is well-known...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C11B9/02A61K36/282A61P29/00
CPCC11B9/025A61K9/0004A61K9/0014A61K36/282A61K2236/37A61K2236/53
Inventor 不公告发明人
Owner 苏州森佰生物科技有限公司
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