A composition for synchronously adjusting glucose and lipid metabolism to treat type 2 diabetes
A technology for diabetes and lipid metabolism disorders, applied in the direction of metabolic diseases, drug combinations, active ingredients of hydroxyl compounds, etc., can solve problems such as lowering blood sugar, side effects, and inability to simultaneously reduce obesity
Active Publication Date: 2019-01-25
XIYUAN HOSPITAL OF CHINA ACAD OF CHINESE MEDICAL SCI
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Problems solved by technology
[0006] The present invention aims to provide the application of a composition of coix soluble cellulose and honokiol in pharmaceuticals. By using the combination of coix soluble cellulose and honokiol according to a specific example, the coix soluble cellulose can significantly improve the The bioavailability of honokiol, the two have a significant synergistic effect, solving the technical problems of serious side effects and other adverse reactions of drugs for treating diabetes in the prior art, and the inability to simultaneously reduce obesity while lowering blood sugar
Method used
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Embodiment 1
[0028] 1.1 Purpose of the experiment
[0029] KK / Upj-Ay mice were given high-fat diet to create a type II diabetes model, and KK / Upj-Ay mice that had been successfully induced into the model were given honokiol by intragastric administration, and the effect of honokiol on type II diabetic mice was investigated. Hypoglycemic effect of the model.
[0030] 1.2 Test samples
[0031] Honokiol was prepared by Xiyuan Hospital, China Academy of Chinese Medical Sciences. Set up three dosage groups of low, middle and high, and the dosages are 25mg / kg / d, 50mg / kg / d and 100mg / kg / d respectively. Prepare suspensions with concentrations of 2.5mg / ml, 5mg / ml and 10mg / ml with sterile water.
[0032] 1.3 Positive control drugs
[0033] Get pioglitazone hydrochloride tablet (15mg * 7 pieces, batch number is 120202, production date is January 31, 2012, valid until December, 2014, produced by Beijing Sun Pharmaceutical Co., Ltd.), ground into fine powder, weighed 40 mg, plus 20 mL of distilled ...
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The invention discloses a composition for synchronous adjustment of glucolipid metabolism and treatment of type II diabetes. A composition of Coix lacryma-jobi water-soluble cellulose and honokiol has the efficacy of improving insulin resistance, also can improve lipid metabolism disorder while lowering blood glucose and reduce weight. Single oral administration application of Coix lacryma-jobi water-soluble cellulose cannot reach the efficacy of lowering blood sugar and improving blood lipid, honokiol has efficacy of synchronous adjustment of blood glucose and blood lipid, but has large dosage. Through proper compatibility of Coix lacryma-jobi water-soluble cellulose and honokiol, Coix lacryma-jobi water-soluble cellulose and honokiol are applied in a composition form, thus reducing the dosage of honokiol to one fifth that of its single use, and the blood glucose lowering efficacy is significantly superior to its separate use. Coix lacryma-jobi water-soluble cellulose and honokiol have obvious synergistic effect, and application of the two as a composition can achieve obvious advantages.
Description
technical field [0001] The invention relates to the application of the composition of coix soluble cellulose and honokiol, in particular to the application of the composition of coix soluble cellulose and honokiol in pharmacy. Background technique [0002] Diabetes mellitus is a chronic endocrine and metabolic disease characterized by hyperglycemia. Its pathological basis is absolute and / or relative lack of insulin, which in turn causes a series of metabolic disorders of sugar, fat, protein, water and electrolytes. The vast majority of diabetes is type II, accounting for 90%-95% of the total number of diabetic patients. According to the epidemic trend forecast, by 2030, the global adults aged 20-79 suffering from diabetes will reach a staggering number of 439 million. Diabetes has become a major disease that seriously endangers human health, and research on its prevention and control has attracted great attention from all over the world. [0003] The key to the treatment o...
Claims
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IPC IPC(8): A61K31/717A61P3/10A61P3/04A61P5/50A61K31/05
Inventor 王建农
Owner XIYUAN HOSPITAL OF CHINA ACAD OF CHINESE MEDICAL SCI