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Preparation method of ferrous sulfate enteric dropping pill

A ferrous sulfate enteric-coated dripping technology is applied in the directions of pill delivery, pharmaceutical formulations, sugar-coated pills, etc., which can solve the problem of not producing ferrous sulfate enteric-coated dripping pills, etc., and achieves convenient taking and carrying, simple equipment, and roundness. high degree of effect

Active Publication Date: 2017-01-25
GUANGXI UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] At present, the dosage form of ferrous sulfate enteric-coated dripping pills has not been produced at home and abroad, and there are almost no related reports.

Method used

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  • Preparation method of ferrous sulfate enteric dropping pill
  • Preparation method of ferrous sulfate enteric dropping pill
  • Preparation method of ferrous sulfate enteric dropping pill

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A preparation method of ferrous sulfate enteric-coated dripping pills, which comprises the following steps:

[0039] (1) Preparation of pellet core: weigh the composite matrix and FeSO according to the weight ratio of 3:1 4 ·7H 2 O. The composite matrix is ​​a mixture of PEG6000 and PEG4000. The weight ratio of PEG6000 and PEG4000 is 1:4. After mixing PEG6000 and PEG4000, heat to 70℃, and then combine the composite matrix with FeSO 4 ·7H 2 O melts at this temperature, fully stir and mix uniformly to obtain a drug solution, keep it for 20 minutes, and then suck the drug solution into the condensate at a drop distance of 2cm and a dropping speed of 10 drops / min, form a pellet, and let it stand for half Take it out after hours, wipe off the condensate and dry it to get it; the temperature of the lower half of the condensate is 0℃, and the condensate is paraffin wax;

[0040] (2) Preparation of enteric-coated film coating solution: soak acrylic resin No. Ⅱ in an ethanol solution ...

Embodiment 2

[0043] A preparation method of ferrous sulfate enteric-coated dripping pills, which comprises the following steps:

[0044] (1) Preparation of pellet core: weigh the composite matrix and FeSO according to the weight ratio 4:1 4 ·7H 2 O, the composite matrix is ​​a mixture of PEG6000 and PEG4000. The weight ratio of PEG6000 and PEG4000 is 4:1. After mixing PEG6000 and PEG4000, heat to 85°C, and then combine the composite matrix with FeSO 4 ·7H 2 O melts at this temperature, fully stir and mix evenly to obtain a drug solution, keep it for 20 minutes, and then suck the drug solution into the condensate at a drip distance of 4cm and a drip rate of 35 drops / min, form a pellet, and let it stand for half Take it out after hours, wipe off the condensate and dry it to get it; the temperature of the lower half of the condensate is 10℃, and the condensate is paraffin wax;

[0045] (2) Preparation of enteric-coated film coating solution: soak acrylic resin No. Ⅱ in an ethanol solution with a ma...

Embodiment 3

[0048] A preparation method of ferrous sulfate enteric-coated dripping pills, which comprises the following steps:

[0049] (1) Preparation of pellet core: weigh the composite matrix and FeSO at a weight ratio of 5:1 4 ·7H 2 O, the composite matrix is ​​a mixture of PEG6000 and PEG4000. The weight ratio of PEG6000 and PEG4000 is 2:1. After mixing PEG6000 and PEG4000, heat to 90℃, and then combine the composite matrix with FeSO 4 ·7H 2 O melts at this temperature, fully stir and mix uniformly to obtain a drug solution, keep it for 20 minutes, and then suck the drug solution into the condensate at a drip distance of 6cm and a drip rate of 50 drops / min, form a pellet, and let it stand for half Take it out after hours, wipe off the condensate, and dry it to get; the temperature of the lower half of the condensate is 20℃, and the condensate is paraffin wax;

[0050] (2) Preparation of enteric-coated film coating solution: soak acrylic resin No. Ⅱ in an ethanol solution with a mass conten...

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Abstract

The invention discloses a preparation method of ferrous sulfate enteric dropping pills. The preparation method comprises the following steps: (1) preparation of pill cores; (2) preparation of an enteric thin-film coating solution; (3) coating, thus obtaining the ferrous sulfate enteric dropping pills. The ferrous sulfate enteric dropping pills prepared by the invention through dropping are small in weight difference, high in roundness, long in dissolution time limit and good in appearance quality and all meet the requirements of Chinese Pharmacopoeia 2010.

Description

Technical field [0001] The invention belongs to the field of medicine preparation, and specifically relates to a preparation method of ferrous sulfate enteric-coated dripping pills. Background technique [0002] At present, iron is an essential trace element for the human body, and the body is highly dependent on iron. Iron deficiency is a nutritional problem that I often encounter. Iron deficiency is the most inevitable problem in both developed and developing countries. Iron does not account for much in the human body, accounting for about four hundred thousandths of the body weight. The iron content of an adult is about 3-5 grams. According to the chemical properties and the role of iron in the body, it is divided into functional iron and reserve iron. Although their storage methods and proportions are different, their functions in the body are roughly the same. Among the microelements, the body's demand for iron is Other elements are irreplaceable, and at the same time they ...

Claims

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Application Information

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IPC IPC(8): A61K9/32A61K33/26A61P3/02A61P7/06
CPCA61K9/284A61K33/26
Inventor 韦媛媛陈晓伟郭莎莎龙圣亿
Owner GUANGXI UNIVERSITY OF TECHNOLOGY
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