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Application of Linderolide H in preparation of lung cancer drugs

A drug and lung cancer technology, applied in the application field of LinderolideH in the preparation of drugs for the treatment of lung cancer, can solve the problem of damage to normal tissues and cells, and achieve the effect of strong cytotoxicity and prominent substantive characteristics

Inactive Publication Date: 2017-01-25
ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Malignant tumors are diseases that seriously threaten human life and health. Chemotherapy drugs commonly used in clinical practice can greatly damage normal tissues and cells while killing tumor cells, which limits its application.

Method used

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  • Application of Linderolide H in preparation of lung cancer drugs
  • Application of Linderolide H in preparation of lung cancer drugs
  • Application of Linderolide H in preparation of lung cancer drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: the preparation of the compound Linderol ide H tablet involved in the present invention:

[0013] Take 20 grams of compound Linderol ide H, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tabletting machine.

Embodiment 2

[0014] Embodiment 2: the preparation of the compound Linderol ide H capsules involved in the present invention:

[0015] Take 20 grams of compound Linderol ide H, add conventional auxiliary materials such as starch 180 grams for the preparation of capsules, mix well, and make 1000 capsules.

[0016] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example

[0017] Experimental example: Linderolide H’s inhibitory effect on the proliferation of lung cancer cells cultured in vitro and its effect on human normal cells

[0018] Impact

[0019] Lung cancer cells in logarithmic growth phase (non-small cell lung cancer cell A549, large cell lung cancer cell NCI-H460, lung squamous cell carcinoma cell HTB-8 and human lung squamous cell carcinoma cell QG-5) and human normal liver cell L02 were inoculated in On a 96-well culture plate, the inoculum volume per well was 3000-4000 cells / 100uL and 6000 cells / 100uL respectively; aseptically collected 15 mL of venous blood from healthy blood donors, anticoagulated with heparin, and separated mononuclear cells by Ficoll density gradient centrifugation. Prepare a single cell suspension with RPMI1640 containing 10% fetal bovine serum, adjust the cell concentration to 2×105 cells / mL, inoculate in a 96-well culture plate, 100 uL per well. After 24 hours of cell culture on the above-mentioned culture ...

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PUM

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Abstract

The invention discloses application of Linderolide H in the preparation of lung cancer drugs; the compound exhibits good lung cancer resisting activity, is applicable to the preparation of lung cancer drugs and belongs to the technical field of novel applications of drugs. Linderolide H can significantly inhibit non-small cell lung cancer cells A549, large cell lung cancer cells NCI-H460, lung squamous carcinoma cells HTB-8 and human lung squamous carcinoma cells QG-5 cultured in vitro, but exhibit low inhibitory action on human normal liver cell LO2 and peripheral blood lymphocyte, and shows significant selectivity; the application of Linderolide H in the preparation of lung cancer drugs is disclosed herein for the first time; since a framework is of brand-new type, the inhibitory activity for lung cancer cells is unexpectedly high.

Description

technical field [0001] The present invention relates to a new application of compound Linderolide H, in particular to the application of Linderolide H in the preparation of drugs for treating lung cancer. Background technique [0002] Malignant tumors are diseases that seriously threaten human life and health. Chemotherapy drugs commonly used in clinical practice can greatly damage normal tissues and cells while killing tumor cells, which limits its application. It has become the direction and urgent task of current anticancer drug research to find highly efficient and low toxic drugs for treating tumors. Finding high-efficiency, low-toxic anticancer drugs has been considered an effective way. [0003] The present invention has confirmed through experiments that Linderolide H has significant inhibitory effect on non-small cell lung cancer cell A549, large cell lung cancer cell NCI-H460, lung squamous cell carcinoma cell HTB-8 and human lung squamous cell carcinoma cell QG-5...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61P35/00A61P1/00
CPCA61K31/365
Inventor 田丽华
Owner ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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