Insecticide composition containing fluorine thiamethoxam sulfone and trifluoro-pyrimidine amide

A technology of triflumidamide and insecticidal composition, which is applied in the field of agrochemicals, and can solve the problems of complicated screening of compound structures, many residues, and long research and development cycles.

Inactive Publication Date: 2017-02-01
冯涵丽
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Problems solved by technology

[0004] Long-term use of a single insecticide will easily lead to insect resistance and increase the amount of pesticide used, leading to adverse consequences such as high toxicity, large dosage, large residues, and poor efficacy, and the field of action is relati...
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Abstract

The invention provides an insecticide composition containing fluorine thiamethoxam sulfone and trifluoro-pyrimidine amide. The insecticide composition contains the fluorine thiamethoxam sulfone and the trifluoro-pyrimidine amide, wherein the weight ratio of the fluorine thiamethoxam sulfone to the trifluoro-pyrimidine amide is (1 to 60) to (1 to 70). The fluorine thiamethoxam sulfone used by the invention is a new chemical nematicide, which belongs to non-fumigation novel nematicide, has greater difference from a function mechanism of the trifluoro-pyrimidine amide of an insecticide, and has no cross resistance.

Application Domain

BiocideDead animal preservation +3

Technology Topic

PyrimidineChemistry +7

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  • Insecticide composition containing fluorine thiamethoxam sulfone and trifluoro-pyrimidine amide
  • Insecticide composition containing fluorine thiamethoxam sulfone and trifluoro-pyrimidine amide
  • Insecticide composition containing fluorine thiamethoxam sulfone and trifluoro-pyrimidine amide

Examples

  • Experimental program(1)
  • Effect test(1)

Example Embodiment

[0098] Specific embodiments: combined toxicity of triflumid and fluthiazol in different ratios
[0099] 1.1 Drugs to be tested
[0100] 95.7% of the original drug of triflumidazol, 95% of the original drug of fluthiazol.
[0101] 1.2 Source of tested insects
[0102] Tomato root-knot nematodes with consistent individual size and physiological state were continuously fed for 5 generations indoors.
[0103] 1.3 Two single-dose indoor toxicity assays
[0104] The two original drugs were dissolved with a small amount of acetone by the worm soaking method, and then diluted with 0.1% Tween aqueous solution to form solutions of 5 equal concentrations, which were diluted in beakers for later use, and clear water was used as a control. Immerse tomato root-knot nematodes of the same size in the liquid medicine soaked in the insect cage for 5 seconds. After absorbing the excess liquid medicine, place them in a petri dish with a diameter of 12 cm. The dish is covered with fresh tomato roots. Each concentration treated 10 heads and repeated 4 times. A blank control was set up. at ( 27±1 ) o C kept in the light incubator for 48 hours to check the mortality rate, and those who did not respond to the worm body with a dial needle were considered dead. The mortality rate was corrected by Abbott's formula, and then according to the concentration logarithm-mortality probability value analysis (Bliss) method, the toxicity regression equation and the lethal median LC were obtained 50 value.
[0105] 2 Optimal ratio screening
[0106] Mixing optimization was carried out by mixing in proportion (Crafte), and the best mixing ratio of triflumidazolamide and fluthiazol was screened out. 48-hour Indoor Toxicity LC of Triflumid and Fluthiazol against Tomato Meloidogyne 50 They are a and b respectively. When the two agents are mixed, they are mixed according to the following proportions to form 11 formulas, that is, a+0, 0.9a+0.1b, 0.8a+0.2b, 0.7a+0.3b, 0.6a+0.4b , 0.5a+0.5b, 0.4a+0.6b, 0.3a+0.7b, 0.2a+0.8b, 0.1a+0.9b, 0+b. Each proportioned medicinal solution was tested for toxicity according to the above-mentioned method, and the death result of tomato root-knot nematode was checked after 24 hours, and the toxicity ratio Table 1 of each proportioning was obtained.
[0107] Table 1 LC 50 dose of triflumid with LC 50 Indoor Toxicity Test Results of Fluthiazol in Different Proportions of Doses to Meloidogyne Nematode of Tomato
[0108]
[0109] According to the results in Table 1, two single-dose LC 50 Based on the different ratios of the composition, the toxicity of root-knot nematode to tomato root-knot nematode is determined. It can be seen from the table that the mixtures of different ratios all have synergistic effects, and their actual inhibition rates are greater than or close to 50%. The toxicity ratio are greater than 1. Among them, the mixture of 0.5a+0.5b had the highest actual mortality rate.
[0110] Therefore, the optimal ratio of the mixture is trifluoroimidinamide LC 50 50% of the value plus fluthiazol LC 50 50% of the value, the ratio of active ingredients converted into two single doses is 1:4.56. Referring to the results of the optimal ratio, actually mix with triflumid : fluthiazol = 1: 4.56 (active ingredient), and the mixed preparation is diluted with acetone to a series of concentrations with a certain gradient, and then the indoor toxicity test is carried out , toxicity regression equation for mixture determination, LC 50 And the co-toxicity coefficient and calculate the co-toxicity coefficient (CTC) according to Sun Yunpei's method. Co-toxicity coefficient CTC, the calculation formula is as follows: (Triflumid is used as the standard drug, and its toxicity index is 100):
[0111] Toxicity index (TI) for fluthiazol = LC for triflumidazol 50 / LC of fluthiazol 50 ×100
[0112] Actual Toxicity Index (ATI) of M = LC of Triflumid 50 /M LC 50 ×100
[0113] Theoretical toxicity index (TTI) of M = TI of triflumidazolamide × P of triflumidazolamide + TI of fluthiazol sulfone × P of fluthiazol
[0114] M's co-toxicity coefficient (CTC) =M's ATI/M's TTI×100
[0115] In the formula:
[0116] M is a mixture of different ratios of fluthiazol and triflumid
[0117] P Fluthiazol is the proportion of fluthiazol in the mixture
[0118] P Triflumid is the proportion of triflumid in the mixture shown in Table 2.
[0119] Table 2 Laboratory toxicity test results of triflumid, fluthiazol and their mixture against tomato root-knot nematode
[0120]
[0121] Table 2 shows that the actual compounding with triflumid : fluthiazol = 1: 4.56 (active ingredient), and then the indoor toxicity test, the co-toxicity coefficient is 196.0131, and its synergistic effect is obvious.
[0122] 3.1 Field experiment to control corn root rot nematode

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