A kind of porcine circular synthetic peptide vaccine and its preparation method and application

A technology for synthesizing peptide vaccines and porcine circoviruses, which is applied in the field of medicine, can solve the problems of difficulty in uniform quality between batches, limited control effect of porcine circovirus disease, and high price, so as to improve safety and specificity and vaccine quality Reliable, inexpensive to produce results
CN106380509BActive Publication Date: 2019-07-26CHINA ANIMAL HUSBANDRY IND
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CHINA ANIMAL HUSBANDRY IND
Publication Date
2019-07-26

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Abstract

The invention provides antigen peptides for preparing a porcine circovirus synthetic peptide vaccine as well as an application. The antigen peptides are peptides shown in the sequence 2, the sequence3 or the sequence 4. The porcine circovirus synthetic peptide vaccine has excellent immune efficiency, and the existing problems of fever, inflammation and the like of traditional vaccines cannot be caused. As a result, the vaccine can effectively cope with present antigen variation of porcine circovirus and no biosecurity, is prone to synthesis on a large scale, and has bright application prospects. The invention also provides a preparation method of the peptides and the peptide vaccine as well as a pharmaceutical application thereof.
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Description

technical field

[0001] The invention relates to the technical field of medicine, and in particular, the invention relates to a porcine circular synthetic peptide vaccine and a preparation method thereof. Background technique

[0002] Porcine circovirus-associated disease (PCVAD) refers to a series of syndromes caused by PCV2 or diseases related to PCV2 infection. According to the difference in PCV antigenicity and genetic composition, it is divided into two genotypes (serotypes). The porcine circovirus associated with clinical disease is named porcine circovirus type 2 (PCV2). The circovirus is named porcine circovirus type 1 (PCV1). Porcine circovirus is the smallest animal virus discovered so far, with a diameter of 17nm, icosahedral symmetry, and no envelope. The viral genome consists of single-stranded negative-strand closed circular DNA, of which PCV1 contains 1759 nucleotides and PCV2 contains 1767 or 1768 nucleotides.

[0003] After PCV2 infects the body, it invade...

Claims

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