Preparation method of alpha, beta-unsaturated ketone

Abstract

The invention provides a preparation method of alpha-beta-unsaturated ketone and relates to the technical field of preparation of alpha, beta-unsaturated ketone compound. According to the preparation method, immobilized proline is utilized as a catalyst, 2,6-dimethylpiperazine is utilized as cocatalyst, and aldehyde and acetone are utilized as reaction raw materials in catalysis and are condensed to generate the alpha, beta-unsaturated ketone. The preparation method has the advantages: 1, the reaction conditions are moderate, and the synthetic method is convenient; 2, the catalyst is stable and can be recycled, and the yield is still higher than 70% after tenth circulation; 3, the catalyst is high in tolerance to an acidic functional group of substrate.

Description

technical field [0001] The invention relates to a synthetic method for preparing ɑ, β-unsaturated ketones. Background technique [0002] α, β -Unsaturated ketones are not only important synthetic building blocks in organic synthesis, but also widely used in many other fields, such as: spices, biopharmaceuticals, pesticides, food and material science, etc. Therefore, this kind of compound has very important research value. Currently, about α, β - There have been many reports in the literature on the research methods of unsaturated ketones, and in these methods, alkaline catalysts and organic solvents are mostly used. The catalysts and solvents used in these methods are harmful to the environment and will cause corrosion to equipment in industrial production , and the solid strong alkaline waste produced after the reaction is also difficult to deal with. These shortcomings limit its large-scale production and application in industry, and at the same time, it does not confor...

AI Technical Summary

Problems solved by technology

Currently, about α, β - There have been many reports in the literature on the research methods of unsaturated ketones, and in these methods, alkaline catalysts and organic solvents are mostly used. The catalysts and solvents used in these methods are harmful to the environment and will cause corrosion to equipment in industrial production , and the solid strong alkaline waste produced after the reaction is also difficult to deal with. These shortcomings limit its large-scale production and application in industry, and it does not conform to the spirit of green chemistry.

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