Gynecological menstruation-regulating slow-release dropping pills and preparation method thereof

A technology for slow-release dropping pills and gynecological menstruation regulation, which is applied in the directions of pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc. Achieve the effect of maintaining blood drug concentration, enhancing drug efficacy and reducing the number of times of medication

Active Publication Date: 2017-03-01
GUIZHOU YIBAI WOMAN BIG PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still some problems in the gynecological regulating menstruation dropping pills made by the existing preparation method: (1) the dropping pills are easily heated and cracked when stored, easy to absorb moisture, sticky pills, deformation and other problems that easily affect product quality, poor drug stability, and long-term storage. Affect the quality of the drug; (2) the prepared drop pills have a quick onset of effect, but the half-life is short, the peak and valley fluctuations of the blood drug are large, the drug is metabolized too fast in the body, the blood drug concentration is difficult to maintain for a long time, and the administration method is inconvenient and not suitable for long-term Disadvantages such as drug administration

Method used

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  • Gynecological menstruation-regulating slow-release dropping pills and preparation method thereof
  • Gynecological menstruation-regulating slow-release dropping pills and preparation method thereof
  • Gynecological menstruation-regulating slow-release dropping pills and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1: Preparation of Gynecology Tiaojing Sustained Release Dropping Pills (low component):

[0039] Prescription: Angelica 18g, Chuanxiong 1g, Rhizoma Cyperi (made with vinegar) 75g, Atractylodes macrocephala 2g, Radix Paeoniae Alba 1g, Radix Paeoniae Rubra 1g, Corydalis Corydalis (roasted with vinegar) 4g, Rehmannia glutinosa 8g, Jujube 14g, Licorice 1g, Ethyl Cellulose 9g, carbomer 4g, polyethylene glycol (2:1 mixture of polyethylene glycol 4000 and polyethylene glycol 6000) 20g;

[0040] Grind the above-mentioned ten Chinese herbal medicines, pass through a 40-mesh sieve, add 6 amounts of 80% ethanol, soak for 2 hours, heat and reflux for 3 hours, filter, recover the ethanol from the filtrate and concentrate it to a thick paste; add 8 amounts of water to the dregs, decoct for 2 hours, Filtrate, concentrate the filtrate to get a thick paste, combine the thick paste obtained by 2 extractions, dry under reduced pressure, pulverize, add the above-mentioned amount...

Embodiment 2

[0041] Embodiment 2: Preparation of Gynecological Tiaojing Sustained Release Dropping Pills:

[0042] Prescription: Angelica 20g, Chuanxiong 2g, Rhizoma Cyperi (made with vinegar) 80g, Atractylodes macrocephala 3g, Radix Paeoniae Alba 2g, Radix Paeoniae Rubra 2g, Corydalis Corydalis (roasted with vinegar) 5g, Rehmannia glutinosa 9g, Jujube 15g, Licorice 2g, Ethyl Cellulose 10g, carbomer 5g, polyethylene glycol (2:1 mixture of polyethylene glycol 4000 and polyethylene glycol 6000) 25g;

[0043] Grind the above-mentioned ten Chinese herbal medicines, pass through a 40-mesh sieve, add 6 amounts of 80% ethanol, soak for 2 hours, heat and reflux for 3 hours, filter, recover the ethanol from the filtrate and concentrate it to a thick paste; add 8 amounts of water to the dregs, decoct for 2 hours, Filtrate, concentrate the filtrate to get a thick paste, combine the thick paste obtained by 2 extractions, dry under reduced pressure, pulverize, add the above-mentioned amount of ethyl ce...

Embodiment 3

[0044] Embodiment 3: Preparation of Gynecological Tiaojing Sustained Release Dropping Pills:

[0045]Prescription: 31.97g Angelica, 3.58g Chuanxiong, 88.9g Rhizoma Cyperi (vinegar-roasted), 5.13g Atractylodes macrocephala, 2.64g Radix Paeoniae Alba, 2.64g Radix Paeoniae Rubra, 7.08g Corydalis Corydalis (roasted with vinegar), 10.66g Rehmannia glutinosa, 17.8g jujube , licorice 2.41g, ethyl cellulose 12.5g, carbomer 7.5g, polyethylene glycol (2:1 mixture of polyethylene glycol 4000 and polyethylene glycol 6000) 30g;

[0046] Grind the above ten Chinese herbal medicines, pass through a 40-mesh sieve, add 7 amounts of 80% ethanol, soak for 3 hours, heat and reflux for 3 hours, filter, recover the ethanol from the filtrate and concentrate it to a thick paste; add 9 amounts of water to the dregs, decoct for 3 hours, Filtrate, concentrate the filtrate to get a thick paste, combine the thick paste obtained by 2 extractions, dry under reduced pressure, pulverize, add the above-mention...

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PUM

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Abstract

The invention provides gynecological menstruation-regulating slow-release dropping pills and a preparation method thereof. According to the present invention, by optimizing the original herb extraction process and using the double extraction method of alcohol extraction and water extraction, the active components of the Chinese herbs are completely extracted; in order to overcome the defects of the gynecological menstruation-regulating dropping pills in the prior art, a lot of test screening researches are performed; and the ethyl cellulose is used to compound so as to provide the good biodegradability, the carbomer has the good slow release effect is adopted as the skeleton material, and a proper amount of polyethylene glycol is added to prepare the slow release dropping pills, such that the product quality is stable, the number of medication can be reduced, the stable plasma concentration can be maintained, and the efficacy can be enhanced.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and in particular relates to a gynecological menstruation regulating sustained-release dripping pill and a preparation method thereof. Background technique [0002] Gynecological diseases such as irregular menstruation and abdominal pain during menstruation are common diseases that threaten women's physical and mental health in the world today, bringing great pain to women. In order to achieve the purpose of prevention and treatment, many inventors and pharmaceutical companies have done a lot of research , also provides some therapeutic products; such as: Fuke Tiaojing Granules, Fuke Tiaojing Capsules, etc. However, the existing products have a large dosage, many times of taking, easy to absorb moisture, and the product quality is unstable. The bioavailability and drug stability of these traditional dosage forms are not ideal, especially the problem that the bioavailability of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8905A61K9/22A61K47/38A61K47/32A61K47/10A61P15/00
Inventor 郎洪平韦玉栋
Owner GUIZHOU YIBAI WOMAN BIG PHARMA FACTORY
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