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Application of dibiphenol in the preparation of drugs for preventing and treating convulsions

A biphenol and drug technology, applied in the field of medicine, can solve problems such as tolerance dependence and addiction, ataxia, coma and respiratory depression

Active Publication Date: 2021-01-08
XIAN LIBANG ZHAOXIN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, long-term use of diazepam is prone to tolerance, dependence, and addiction. Rebound and withdrawal symptoms occur when the drug is stopped. Large doses can cause ataxia, and poisoning can cause coma and respiratory depression, especially diazepam. Panan has a strong inhibitory effect on the central nervous system, which may affect the growth and development of the nervous system and cognitive ability of children

Method used

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  • Application of dibiphenol in the preparation of drugs for preventing and treating convulsions
  • Application of dibiphenol in the preparation of drugs for preventing and treating convulsions
  • Application of dibiphenol in the preparation of drugs for preventing and treating convulsions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1. Biphenol (compound 1) lipid microsphere preparation

[0029]

[0030] Preparation Process

[0031] (1) Dissolve 12g egg yolk lecithin with 100g oil for injection in a water bath at 70°C under nitrogen protection, add 10.0g biphenol and 10g vitamin E, pass through nitrogen protection, heat and stir to dissolve to obtain the oil phase ;

[0032] (2) 25g of glycerin is dissolved in water for injection, and stirred evenly to obtain an aqueous phase;

[0033] (3) Slowly add the oil phase to the water phase, and shear (10000r, 5min) under the protection of nitrogen at the same time to obtain colostrum, and adjust the pH to about 8.0 with sodium hydroxide.

[0034] (4) Homogenize the prepared colostrum for 5 to 8 times under the pressure of 800 to 900 bar, filter through a microporous membrane, fill with nitrogen, potting, and sterilize under high pressure at 115° C. to obtain the final product.

Embodiment 2

[0035] Embodiment 2. bisphenol monoethyl ester (compound 2) lipid microsphere preparation

[0036]

[0037] Preparation technology is the same as embodiment 1

Embodiment 3

[0038] Embodiment 3. Biphenol diethyl ester (compound 3) lipid microsphere preparation

[0039]

[0040] Preparation technology is the same as embodiment 1

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Abstract

The invention belongs to the technical field of medicines, relates to a new application of a drug, and particularly relates to applications of biphenyl in the preparation of a drug for preventing and treating convulsion.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a new medicine application. It specifically relates to a new application of biphenol for preventing and treating convulsions. Background technique [0002] Convulsions are commonly known as cramps, convulsions, and convulsions, also known as convulsions. It is manifested as paroxysmal limb and facial muscle twitches, often accompanied by upturned eyeballs, staring or strabismus on both sides, and confusion. Sometimes it is accompanied by foaming at the mouth or the corners of the mouth, apnea, and blue complexion. The attack time is usually within 3 to 5 minutes, and sometimes the attack occurs repeatedly, or even in a continuous state. It is a common emergency in children, especially in infants and young children. The development of the cerebral cortex of infants and young children is not perfect, so the analysis, identification and inhibition functions are poor; the medically ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/05A61K31/222A61P25/08A61P3/08
CPCA61K31/05A61K31/222
Inventor 王汝涛安龙赵熠郭树攀陈涛
Owner XIAN LIBANG ZHAOXIN BIOTECH CO LTD