57 results about "Biphenylol" patented technology

The invention relates to an application of 3,3',5,5'-tetraisopropyl-4,4'-diphenol and pharmaceutical salts, ester compounds or solvent compounds thereof in preparation for traditional Chinese medicines for preventing and treating ischemic stroke. The structure of the diphenol structure is specified in the description.

Stable, homogeneous melt solutions are prepared at temperatures of 200 DEG C or less from solid mixtures comprising at least one diaryl carbonate, at least one high melting dihydroxy aromatic compound (mp>200 DEG C), a transesterification catalyst, and optionally a lower melting dihydroxy aromatic compound. Thus, a stable, homogeneous melt solution is obtained from a solid mixture comprising 4,4'-biphenol(mp 282-284 DEG C) at a temperature of about 200 DEG C using either diphenyl carbonate or bis(methyl salicyl) carbonate as the diaryl carbonate component. It is shown that formation of the stable, homogeneous melt solutions requires the presence of the transesterification catalyst when substantial amounts of the high melting dihydroxy aromatic compound are present in the initial solid mixture. Solid mixtures comprising a variety of high melting bisphenols; 4,4'-biphenol; 3,3,3,3'tetramethylspirobiindanbisphenol, and 4,4'-sulfonydiphenol are converted to stable, homogeneousmelt solutions at 200 DEG C, a temperature substantially below the melting points of the high melting bisphenols in their pure states.

The present invention relates to a compound of formula I or a pharmaceutically acceptable salt thereof. In formula (I), R 1 and R 2 Each independently is H or alkyl; Y is alkyl, CONR 3 R 4 、COOR 5 , SO 2 NR 16 R 17 , NHSO 2 R 18 or CN; X is aryl or heteroaryl, each of which may optionally be substituted by one or more substituents selected from (CH 2 ) m Z, where Z is halogen, OH, CN, alkyl, alkoxy, NO 2 、CF 3 、CONR 6 R 7 , CN, NR 8 R 9 、COOR 10 or NHCOR 11 , m is 0 to 3; R 3 to R 11 Each is independently H, alkyl or aryl, wherein the alkyl and aryl are optionally substituted by one or more substituents selected from halogen, OH, CN, alkyl, alkoxy , NO 2 、CF 3 、CONR 12 R 13 , CN, NH 2 、COOR 14 , NHCOR 15 and CN; R 12 to R 18 Each independently is H or alkyl, more preferably H or Me; n is 1 to 6; wherein the compound is not 3',5'-dimethyl-4-(1,1-dimethylheptyl)- 1,1'-biphenyl-2-phenol. Another aspect of the invention relates to the use of such compounds for the manufacture of a medicament for the treatment of muscular disorders, gastrointestinal disorders or for the control of spasticity or tremor.

The present invention relates to an antimicrobial composition. More particularly the present invention relates to an antimicrobial composition for malodor and oral biofilm inhibitions benefits. Accordingly, the present invention provides an antimicrobial composition comprising: a, 0.1 to 10% by weight of tetrahydroxypropyl ethylenediamine (THPE) and, and b, 0.001 to 10% by weight of at least one compound selected from a biphenol.