Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Water-soluble coagulant drug vitamin k2 solid-state complex and preparation method thereof

A vitamin and procoagulant technology, applied in the field of medicine, to achieve the effect of improving solubility

Inactive Publication Date: 2017-03-22
YUNNAN NORMAL UNIV
View PDF7 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, the inclusion of vitamin K with modified β-cyclodextrins is currently 2 The study of molecular solid-state complexes has not been reported, although solid-state complexes have the advantages of easy portability, transportation and storage, good stability, and no need to add preservatives during preparation

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Water-soluble coagulant drug vitamin k2 solid-state complex and preparation method thereof
  • Water-soluble coagulant drug vitamin k2 solid-state complex and preparation method thereof
  • Water-soluble coagulant drug vitamin k2 solid-state complex and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0036] Mono-[6-(diethylenetriamine)-6-deoxy]-β-cyclodextrin and vitamin K involved 2 The solid complexes were synthesized as follows:

[0037] 1) Synthesis of mono-[6-(diethylenetriamine)-6-deoxy]-β-cyclodextrin 2 Mono-[6-(diethylenetriamine)-6-deoxy]-β-cyclodextrin For the detailed synthetic route, see Figure 14 (Synthesized according to literature, I.Tabushi, N.Shimizu, T.Sugimoto, M.Shiozuka, K.Yamamura, J.Am.Chem.Soc.1977,99,7100; I.Tabushi, N.Shimizu, Jpn.Kodai Tokkyo Koho 78 102 985, 1978 [Chem. Abstr., 1979, 90, 39196b]).

[0038] Into a 100mL dry round-bottomed flask, add 40mL of diethylenetriamine purified by distillation, add 5.0g of mono-(6-oxo-6-p-toluenesulfonyl)-β-cyclodextrin while stirring, protect with nitrogen, and dissolve Raise the temperature to about 76°C and react for 7 hours, then distill off most of the diethylenetriamine under reduced pressure, add the remaining liquid to acetone, collect the precipitate by suction filtration, repeat the operation...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a water-soluble coagulant drug vitamin k2 solid-state complex and a preparation method thereof, and belongs to the technical field of medicines. The product is a solid-state complex of mono-[6-(diethylenetriamine)-6-deoxy]-[beta]-cyclodextrin and vitamin K2 at a mixing ratio of 2 to 1. The mono-[6-(diethylenetriamine)-6-deoxy]-[beta]-cyclodextrin is obtained by adding mono-(6-o-6-p-toluenesulfonyl)-[beta]-cyclodextrin to diethylenetriamine, conducting a reaction in a mode of dissolving and increasing temperature in a nitrogen atmosphere, adding acetone after most diethylenetriamine is distilled so as to obtain a crude product, dissolving the crude product in a water and separating the dissolved product so as to obtain the mono-[6-(diethylenetriamine)-6-deoxy]-[beta]-cyclodextrin. A vitamin K2 acetone solution is added to a mono-[6-(diethylenetriamine)-6-deoxy]-[beta]-cyclodextrin water solution, and it conducts stirring at 35-40 DEG C in a sealed mode for 4.5-5.5 days so as to remove acetone and vitamin K2 failing to participate in inclusion. The obtained product (the solid-state complex) is low in toxicity; and the solubility of the vitamin K2, through inclusion, in water is increased by 110 times, and the product, as a vitamin K2 substitute, is applicable to the clinical field.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to water-soluble procoagulant drug vitamin K 2 Solid state composite and method for its preparation. Background technique [0002] Vitamin K 2 (English name menaquinone) has the following structure: [0003] [0004] Refers to a family of homologues of 2-methyl-1,4-naphthoquinone, the third position of which is substituted by isopentenyl side chains containing 4 to 13 isoprene units, these are called menaquinones; The suffix (-4) indicates the number of isodiene units on the side chain. In 1934, Danish scientists first discovered vitamin K and confirmed that it was a fat-soluble vitamin. naturally occurring vitamin K 1 、K 2 , Vitamin K 1 Widely present in green plants, it is an important source of vitamin K in food; vitamin K 2 Mainly synthesized by intestinal bacteria. Vitamin K is biologically active in animals 2 , while vitamin K 1 and vitamin K 3 be converted in...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/14A61K31/122A61K47/40A61P7/04A61K47/69
CPCA61K31/122A61K9/146
Inventor 赵焱杨自明朱茜朱洪友阮琼郑萍尹华滔
Owner YUNNAN NORMAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com