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Hemostasis spraying type adhesive and preparation method thereof

An adhesive and adhesive liquid technology, applied in surgical adhesives, pharmaceutical formulations, applications, etc., can solve the problems of low adhesive strength, inconvenient use, poor diffusion, etc., and achieve increased surface area, effective hemostasis, and particle size. and excellent particle size

Active Publication Date: 2017-03-22
FUALIE SCI & TECH DEVING BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The invention provides an adhesive and a preparation method thereof, which can overcome the disadvantages of inconvenient use caused by the need for low-temperature storage of the existing medical adhesives; and also overcome the low bonding strength, slow polymerization, and strong odor of the existing adhesives. , poor diffusivity, and avoid the risk of iatrogenic CJD spongiform cerebrovascular disease, antiviral infection, hepatitis C virus infection and AIDS caused by the use of blood products

Method used

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  • Hemostasis spraying type adhesive and preparation method thereof
  • Hemostasis spraying type adhesive and preparation method thereof
  • Hemostasis spraying type adhesive and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A method for preparing hemostatic spray adhesive, characterized in that the method comprises the following steps:

[0040] Step 1. Preparation of adhesive

[0041] Add the phenol derivative to medical ethanol, heat to 40°C and reflux until completely dissolved, then heat to 45°C, add the mixture of polyethylene glycol and maleic anhydride, stir and react for 5-8h, wash with saturated NaCl solution for 3-6 Time, stand for 30-60 minutes, filter off the supernatant of the upper layer, use the light yellow transparent adhesive liquid of the lower layer, the mass ratio of the phenol derivative, medical ethanol, polyethylene glycol and maleic anhydride is 3-5: 20-30:1-2:1-2;

[0042] Step two, preparation of nanoparticles:

[0043] Place the substrate in the first solution, blow nitrogen at the same time at 45°C, stir for 15-20min, then reduce to room temperature, add acid solution to keep the pH of the system at 5-8, preferably 5.5-6.5, stir for 1~ 4 hours to obtain a milky white ...

Embodiment 2

[0066] A hemostatic spraying adhesive, which is characterized in that the compound has α-n-octyl cyanoacrylate compound and α-n-butyl cyanoacrylate, and the structural formula of the n-octyl cyanoacrylate compound is shown in formula 3.

[0067]

[0068] The mass ratio of the n-octyl α-cyanoacrylate compound and the n-butyl α-cyanoacrylate is 4.5:5.5, and the hemostatic spray adhesive containing α-cyanoacrylate alkoxy ester is suitable for use In vivo and in vitro operations include: general hepatobiliary, pancreatic, spleen, gastrointestinal, cardiothoracic, extraneurological, extraneural, tumor, obstetrics and gynecology, burn plastic surgery, extraosseous, oral, ENT and other operations for hemostasis, adhesion, covering, Plugging, hard tissue fixation, etc.

[0069] 1. Prevention and treatment of cerebrospinal fluid leakage

[0070] 1) Open head injury:

[0071] The local cap-shaped aponeurosis is broken, the muscle membrane is used to cover the damage, and the periphery is seale...

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Abstract

The invention relates to a hemostasis spraying type adhesive and a preparation method thereof. The method comprises the following steps: preparing an adhesive solution; preparing nanometer grains; preparing an amine chitosan derivative; preparing the final adhesive. The adhesive prepared according to the method has the advantages that the gelation time required by adhesion is short, the mechanical strength is excellent, the bleeding can be quickly stopped and the adhesive also has quick and strong adhering property even under the existence of water.

Description

Technical field [0001] The invention relates to a hemostatic spraying adhesive and a preparation method thereof. Background technique [0002] In the field of clinical medicine, the problem of hemostasis caused by large-area bleeding or blood vessel bleeding during surgery has been plagued by the medical community. There is an urgent need for a material that can quickly stop bleeding and bond the wound. Conventional surgical techniques ensure strong tension. Stretching strength, but it has the disadvantages of pain and the need to remove stitches after surgery. On the other hand, tissue adhesives enjoy the advantages of short bonding time, simple usage, and no need for postoperative removal. However, tissue adhesives exhibit low adhesion, poor biocompatibility, and poor tensile strength, and particularly It is a problem that the adhesion is significantly reduced in the presence of moisture. [0003] The emergence of medical adhesives has changed the traditional medical concept of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/10A61L24/00A61L24/08
CPCA61L24/00A61L24/0031A61L24/08A61L24/102A61L2400/04A61L2400/12C08L5/08
Inventor 田霞
Owner FUALIE SCI & TECH DEVING BEIJING
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