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Composition for medicinal material deodorization and preparation method and application thereof

A technology of composition and medicinal material, which is applied in the field of medicinal material deodorizing composition, can solve the problems of obvious fishy smell, unfavorable development and application of philium phenanthrae freeze-dried powder, and difficult acceptance by patients, so as to achieve high anticoagulant activity and method Efficient, feel good effect

Inactive Publication Date: 2017-05-03
云南云域瑞达生物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The fishy smell is obvious when taken orally, which is not easy to be accepted by patients, which is not conducive to the development and application of the lyophilized powder.

Method used

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  • Composition for medicinal material deodorization and preparation method and application thereof
  • Composition for medicinal material deodorization and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1 A kind of pharmaceutical composition with anticoagulant activity

[0034] Take the raw materials according to the following weight ratio:

[0035] 5g of chrysanthemum, 21g of cyclodextrin, 80g of freeze-dried powder of leeches

[0036] The preparation method is as follows:

[0037] a. Take the chrysanthemum, add 20 times the amount of 60% v / v ethanol to reflux extraction, extract for 1 hour, evaporate the ethanol from the extract, cool and filter to obtain the chrysanthemum extract;

[0038] b. Take the cyclodextrin and dissolve it to obtain a cyclodextrin solution;

[0039] c. Mix the chrysanthemum extract with the cyclodextrin solution.

[0040] d. Take the mixed solution in step c and mix it evenly with the freeze-dried powder of B. phenanthrae, take a water bath at 50°C for 1 hour, dry it at below 60°C, and pulverize it to obtain the pharmaceutical composition of the present invention.

Embodiment 2

[0041] Embodiment 2 A kind of pharmaceutical composition with anticoagulant activity

[0042] Take the raw materials according to the following weight ratio:

[0043] 5g of chrysanthemum, 7g of cyclodextrin, 40g of freeze-dried powder of leeches

[0044] The preparation method is as follows:

[0045] a. Take the chrysanthemum, add 20 times the amount of 60% v / v ethanol to reflux extraction, extract for 1 hour, evaporate the ethanol from the extract, cool and filter to obtain the chrysanthemum extract;

[0046] b. Take the cyclodextrin and dissolve it to obtain a cyclodextrin solution;

[0047] c. Mix the chrysanthemum extract with the cyclodextrin solution.

[0048] d. Take the mixed solution in step c and mix it evenly with the freeze-dried powder of B. phenanthrae, take a water bath at 50°C for 1 hour, dry it at below 60°C, and pulverize it to obtain the pharmaceutical composition of the present invention.

Embodiment 3

[0049] Embodiment 3 A kind of pharmaceutical composition with anticoagulant activity

[0050] Take the raw materials according to the following weight ratio:

[0051] 15g of chrysanthemum, 7g of cyclodextrin, 80g of freeze-dried powder of leeches

[0052] The preparation method is as follows:

[0053] a. Take the chrysanthemum, add 20 times the amount of 60% v / v ethanol to reflux extraction, extract for 1 hour, evaporate the ethanol from the extract, cool and filter to obtain the chrysanthemum extract;

[0054] b. Take the cyclodextrin and dissolve it to obtain a cyclodextrin solution;

[0055] c. Mix the chrysanthemum extract with the cyclodextrin solution.

[0056] d. Take the mixed solution in step c and mix it evenly with the freeze-dried powder of B. phenanthrae, take a water bath at 50°C for 1 hour, dry it at below 60°C, and pulverize it to obtain the pharmaceutical composition of the present invention.

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Abstract

The invention provides a composition for medicinal material deodorization. The composition comprises a preparation prepared from, by weight, 5-15 parts of chrysanthemum flowers and 7-21 parts of cyclodextrin. The invention further provides a preparation method and application of the composition. By means of the prepared composition, the fishy smells of poecilobdella manillensis freeze-dried powder can be obviously reduced, the poecilobdella manillensis freeze-dried powder can keep high anticoagulant activity, and the beneficial effects of being efficient, safe, free of toxins, free of pollution, simple, easy to implement and the like are achieved.

Description

technical field [0001] The invention relates to a composition for deodorizing medicinal materials, a preparation method and application thereof. Background technique [0002] The application of animal medicinal materials in my country has a long history. Animal medicinal materials have high medicinal value, but most animal medicinal materials or their processed products have a strong fishy smell, which is difficult for patients to accept when taken orally. [0003] The lyophilized powder of phenanthrene leech is the processed product of the fresh whole of the leech phenanthrene Poecilobdella manillensis Lesson. Its main functions are breaking the blood and dredging the menstrual flow, removing blood stasis and eliminating symptoms. It is mostly used in the treatment of cardiovascular and cerebrovascular diseases such as hypertension, hyperlipidemia, cerebral hemorrhage, and cerebral thrombosis in modern clinical practice. [0004] The freeze-dried powder of Hirudo phenanth...

Claims

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Application Information

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IPC IPC(8): A61K47/46A61K47/40A61K35/62A61K35/32A61P7/02
Inventor 段红宇魏恒
Owner 云南云域瑞达生物药业有限公司
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