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Method for preparing biodegradable polymer scaffold

A technology for degrading polymers and polymer materials is applied in the field of preparation of biodegradable polymer stents, which can solve the problems of easy fracture of stents, inability to slow down the physical aging of materials, and insignificant technical advantages, and achieves improved strength and toughness, It is not easy to break, and the effect of reducing the breaking phenomenon

Inactive Publication Date: 2017-05-10
SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, after research, it was found that the technical advantages of the above-mentioned treatment effect are not obvious, and the physical aging of the material cannot be slowed down, and the stent treated by this method is still prone to fracture

Method used

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  • Method for preparing biodegradable polymer scaffold
  • Method for preparing biodegradable polymer scaffold
  • Method for preparing biodegradable polymer scaffold

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0043] The present invention generally provides a method for preparing a biodegradable polymer scaffold, comprising the following steps:

[0044] Step 1): preparing a biodegradable polymer original pipe 2 from a biodegradable polymer material;

[0045] Step 2): Put the original pipe material 2 prepared in the step 1) into the tubular mold 1 (such as figure 1 As shown, the original pipe material 2 is inserted into the inner hole of the tubular mold 1), the original pipe material 2 is heated, and high-pressure gas is injected into the original pipe material 2 to move along the radial direction of the original pipe material 2 Inflation of the original pipe material 2, so that the outer diameter of the pipe material 3 after inflation is equal to the inner diameter of the tubular mold 1 (as figure 2 shown), so that the tube can be highly oriented in the radial direction; and, the tube can be axially stretched along the axial direction of the tube before blowing the tube along sai...

example 1

[0064] The polymer material of the original tubing 2 selected in this example is polylactic acid, a biodegradable polymer material. The polylactic acid particles were extruded to obtain a raw pipe 2 with an outer diameter of 1.5 mm and a wall thickness of 0.5 mm. Put this original pipe 2 into a stainless steel tubular mold 1 with an internal diameter of 2.5mm, such as figure 1 shown in . One end of the polylactic acid original pipe material 2 is closed, and the other end is connected with a high-pressure gas circuit. First, the original pipe 2 and the tubular mold 1 are heated to raise the temperature to 120° C., and then the original pipe 2 is filled with high-pressure nitrogen with a pressure of 200 psi (pounds per square inch), and the original pipe 2 is axially Stretch, the stretching distance is 40mm. The original pipe 2 is prepared under the conditions of high temperature, high pressure and stretching into a pipe with an outer diameter of 2.5 mm and a wall thickness o...

example 2

[0069] The polymer material of the original pipe 2 selected in this example is the biodegradable polymer material polylactic acid-polyglycolic acid copolymer (PLGA), and the copolymerization ratio is 85:15. The copolymerized particles were injection-molded to obtain an original pipe material 2 with an outer diameter of 1.2 mm and a wall thickness of 0.3 mm. This raw pipe material 2 was put into a stainless steel tubular mold 1 with an inner diameter of 2.5 mm. One end of the PLGA original pipe 2 is closed, and the other end is connected with a high-pressure gas circuit. First, the original pipe 2 and the tubular mold 1 are heated to 80° C., and then the original pipe 2 is filled with high-pressure helium at a pressure of 400 psi. The original pipe 2 was prepared under high temperature and high pressure conditions into a pipe with an outer diameter of 2.5 mm and a wall thickness of 0.15 mm. Afterwards, the entire system is rapidly cooled to 20° C., and then the pressure is re...

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Abstract

The invention provides a method for preparing a biodegradable polymer scaffold. The method comprises the steps of 1, preparing a biodegradable polymer original tube stock from a biodegradable polymer material; 2, placing the original tube stock in a tubular mold, conducting heating, injecting high-pressure gas into the original tube stock to enable high orientation of the tube stock in the radial direction, and conducting axial tension on the tube stock in the axial direction of the tube stock so as to achieve simultaneous orientation of the tube stock in the radial direction and the axial direction; 3, annealing the inflated tube stock at the annealing temperature to obtain a molded tube stock, wherein the annealing temperature is higher than the glass-transition temperature of the polymer material and lower than the melting temperature of the polymer material; 4, preparing the molded tube stock into the biodegradable polymer scaffold. By the adoption of the method, the immediate support force of the scaffold is high, breakage does not occur easily, the internal stress of the tube stock can be effectively released, and therefore the shelf life of the scaffold can be prolonged.

Description

technical field [0001] The invention relates to a preparation method of a biodegradable polymer bracket for medical use. Background technique [0002] As an important device for the treatment of vascular stenosis, stent has been widely used in the field of cardiovascular diseases. For metal stents that are widely used in clinical practice at present, because they will permanently remain in the human body after completing the treatment task, they will weaken MRI or CT images of coronary arteries, interfere with surgical revascularization, hinder the formation of collateral circulation, and inhibit the positive blood flow of blood vessels. Remodeling and other defects. Based on these problems, biodegradable scaffolds have attracted much attention as a possible alternative solution. [0003] Biodegradable stents are made of degradable polymer materials or metal materials. After being implanted in the lesion, the biodegradable stent can support blood vessels in a short period...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/90
CPCA61F2/90A61F2210/0004A61F2240/001A61F2/91B29C49/0005B29C49/04B29K2995/006B29C71/02B29C2071/022B29C71/0063B29C71/0072
Inventor 陈宝爱孟娟陈树国罗七一
Owner SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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