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Application of gentiopicroside used as medicine for preventing and treating epileptic attack and cerebral injury

A technology for gentiopicroside and epilepsy, which is applied in the application field of gentiopicroside as a drug for preventing and treating epilepsy and brain injury, and achieves the effect of promoting expression

Active Publication Date: 2017-05-10
NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, whether gentiopicroside can prevent epileptic seizures and improve cranial nerve damage by affecting the changes of NMDA receptors has not been reported yet.

Method used

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  • Application of gentiopicroside used as medicine for preventing and treating epileptic attack and cerebral injury
  • Application of gentiopicroside used as medicine for preventing and treating epileptic attack and cerebral injury
  • Application of gentiopicroside used as medicine for preventing and treating epileptic attack and cerebral injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The use of gentiopicroside as a drug for preventing and treating epileptic seizures and brain damage, the structural formula of gentiopicroside is shown in formula (1):

[0035]

[0036] Among them, the brain injury is the cranial nerve injury caused by epilepsy in the acute stage or the recovery stage. The single application dose of gentiopicroside is limited to the dose that does not cause blood sugar drop. The single application dose of gentiopicroside is 200mg / kg for mice, The dosage form of the medicine is an injection dosage form.

Embodiment 2

[0038] The use of gentiopicroside as a drug for preventing and treating epileptic seizures and brain damage, the structural formula of gentiopicroside is shown in formula (1):

[0039]

[0040] Among them, the brain injury is the cranial nerve injury caused by epilepsy in the acute stage or the recovery stage. The single application dose of gentiopicroside is limited to the dose that does not cause blood sugar drop. The single application dose of gentiopicroside is 400mg / kg for mice, The dosage form of the medicine is an injection powder dosage form.

Embodiment 3

[0042] The use of gentiopicroside as a drug for preventing and treating epileptic seizures and brain damage, the structural formula of gentiopicroside is shown in formula (1):

[0043]

[0044] Among them, the brain injury is the cranial nerve injury caused by epilepsy in the acute stage or the recovery stage. The single application dose of gentiopicroside is limited to the dose that does not cause blood sugar drop. The single application dose of gentiopicroside is 800mg / kg for mice, The dosage form of the medicine is an injection powder dosage form.

[0045] The following animal experiment has further illustrated the effect of above-mentioned embodiment 1 to 3:

[0046] 1. Experimental materials

[0047] 1.1 Animal handling

[0048] Male ICR mice, weighing 18-22 g, were purchased from the Experimental Animal Center of Ningxia Medical University, animal production license number: NCXK (Ning) 2013-0005. Feeding conditions include standard feed, tap water, room temperature...

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Abstract

The invention discloses application of gentiopicroside (Gent) used as a protection medicine for preventing and treating epilepsy and epileptic cerebral injury. The application has the advantages that as shown by experimental results, the seizure attack latent periods of mice can be obviously prolonged when the gentiopicroside is used in safe dose ranges, the death rate can be reduced, and injury and death of hippocampal neurons of the mice after the mice are subjected to epileptic injury can be recovered; certain dose-efficacy correlation is shown and states that effects of delaying epileptic seizure, improving epileptiform activities and repairing injured cerebral nerves can be realized by the gentiopicroside.

Description

technical field [0001] The invention relates to the application of gentiopicroside, in particular to the application of gentiopicroside as a drug for preventing and treating epileptic seizures and brain damage. Background technique [0002] Epilepsy is a brain disorder characterized by sudden, recurrent, and transient brain dysfunction caused by excessive hypersynchronized electrical discharges of brain neurons. It is a disease of abnormal manifestations of the central nervous system. . The pathogenesis of epilepsy is complex and diverse, and has not yet been fully elucidated. Epidemiological survey results estimate that there are about 9 million epilepsy patients in my country, of which 6 million are active patients, and it is estimated that there are about 400,000 new patients each year. Currently, drugs are mainly used for clinical treatment of epilepsy, and so far there is no fundamental and effective measure for its post-injury treatment. How to effectively prevent e...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P25/08A61P25/00
CPCA61K31/7048
Inventor 余建强刘刚汪静马鹏生李玉香孙涛
Owner NINGXIA MEDICAL UNIV
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