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Preparation method for biodegradable medical ultrasonic coupling agent

An ultrasonic coupling agent, biological technology, applied in botany equipment and methods, biocides, echo/ultrasonic imaging agents, etc. And problems such as biodegradability, skin irritation and allergic reaction, to achieve good biocompatibility and biodegradability, remarkable sound transmission effect, and good sliding properties

Inactive Publication Date: 2017-05-10
董晓
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem mainly solved by the present invention: the sterilization efficiency of the existing medical ultrasonic coupling agent is low, long-term use will cause the bacteria to develop drug resistance, and it does not have biocompatibility and biodegradability, which will cause irritation and allergy to the skin Reaction defect, provide a kind of method that extracts camphor oil and compound preparation antibacterial and degradable medical ultrasonic coupling agent with the laminar gum that extracts from kelp, the present invention firstly makes camphor fruit into slurry and mixes and extracts with ethanol solution, obtains ethanol The extract, then grind the kelp, mix it with ethanol solution and oscillate, then put it aside for aging with hydrochloric acid and centrifuge it, collect the supernatant, adjust the pH, filter it with an ultrafiltration membrane, then drop it into a calcium chloride solution for reaction, and then extract it Filtrate and collect the extracted filtrate, mix and modify it with deionized water, glycerin, etc. to obtain a biodegradable medical ultrasonic coupling agent, and the biodegradable medical ultrasonic coupling agent prepared by the present invention The coupling agent effectively solves the problem that the existing coupling agent does not have biocompatibility and biodegradability. After use, it will not cause skin irritation and toxic side effects. At the same time, the sterilization efficiency of the coupling agent is improved, and it has a broad spectrum of sterilization characteristics, has a broad application space

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0018] First collect fresh camphor fruit, wash it and dry it naturally, then place it in a homogenizer for 10 minutes to collect the camphor fruit slurry, and mix the camphor fruit slurry with the mass fraction in a mass ratio of 1:8 Stir and mix the 90% ethanol solution, let it stand at room temperature for extraction for 6 hours, filter and collect the filtrate, and prepare the ethanol extract of camphor fruit, and set aside; then select fresh kelp, wash it with water and dry it naturally, and dry it The kelp was ground and passed through a 50-mesh sieve, and the dried kelp particles were collected. According to the mass ratio of 1:5, the dried kelp particles were stirred and mixed with the ethanol solution with a mass fraction of 95%, and ultrasonically oscillated at 200W for 10 minutes to prepare a kelp particle dispersion. According to the volume ratio of 1:5, add 0.5mol / L hydrochloric acid to the kelp particle dispersion, and let it age for 6h; % sodium hydroxide solutio...

example 2

[0021]First collect fresh camphor fruit, wash it and dry it naturally, then place it in a homogenizer for 13 minutes, collect the camphor fruit slurry, and mix the camphor fruit slurry with the mass fraction Stir and mix the 90% ethanol solution, leave it at room temperature for extraction for 7 hours, filter and collect the filtrate, and prepare the ethanol extract of camphor fruit for future use; then select fresh kelp, wash it with clean water and dry it naturally, and dry it Grind the kelp and pass through a 50-mesh sieve, collect the dried kelp particles, stir and mix the dried kelp particles with a mass fraction of 95% ethanol solution at a mass ratio of 1:5, and ultrasonically vibrate at 250W for 13 minutes to prepare a kelp particle dispersion, then According to the volume ratio of 1:5, add 0.5mol / L hydrochloric acid to the kelp particle dispersion, and let it age for 7h; % sodium hydroxide solution to adjust the pH to 7.0 to prepare a neutralized extract, filter the n...

example 3

[0024] First collect fresh camphor fruit, wash it and dry it naturally, then place it in a homogenizer for 15 minutes to collect the camphor fruit slurry, and mix the camphor fruit slurry with the mass fraction Stir and mix the 90% ethanol solution, let it stand at room temperature for extraction for 8 hours, filter and collect the filtrate, and prepare the ethanol extract of camphor fruit, and set aside; then select fresh kelp, wash it with water and dry it naturally, and dry it Grind the kelp and pass through a 50-mesh sieve, collect the dried kelp particles, stir and mix the dried kelp particles with a mass fraction of 95% ethanol solution at a mass ratio of 1:5, and ultrasonically vibrate at 300W for 15 minutes to prepare a kelp particle dispersion, then According to the volume ratio of 1:5, add 0.5mol / L hydrochloric acid to the kelp particle dispersion, and let it age for 8h; % sodium hydroxide solution to adjust the pH to 7.0 to prepare a neutralized extract, filter the ...

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Abstract

The invention discloses a preparation method for a biodegradable medical ultrasonic coupling agent, and belongs to the technical field of medical product preparation. The preparation method comprises the following steps: firstly, pulping cinnamomum camphora, mixing the pulp with an ethanol solution, extracting to obtain an ethanol extract; grinding kelp, oscillating the ground kelp together with the ethanol solution, standing together with hydrochloric acid, aging and performing centrifugal separation; collecting supernatant, adjusting the pH, and filtering with an ultrafiltration membrane; dropwise adding a calcium chloride solution for reacting; performing suction filtration, collecting filtrate, modifying together with the cinnamomum camphora ethanol extracting solution, and mixing with deionized water, glycerinum and the like to obtain the biodegradable medical ultrasonic coupling agent. By adopting the biodegradable medical ultrasonic coupling agent, the problem that the conventional coupling agent is not biocompatible or biodegradable is solved effectively, and no skin simulation and toxic and side effects are produced after use; meanwhile, the sterilizing efficiency of the coupling agent is increased; the coupling agent has a bactericidal broad-spectrum characteristic and a wide application space.

Description

technical field [0001] The invention discloses a preparation method of a biodegradable medical ultrasonic coupling agent, belonging to the technical field of medical product preparation. Background technique [0002] When ultrasonic waves are incident on the interface between two different media, the greater the difference in impedance between the two, the greater the reflection coefficient, and the less sound energy that passes through the interface into another medium. For medical ultrasound, if the probe is in "dry contact" with the skin, the ultrasonic waves emitted by the probe cannot enter the human body at all due to the strong reflection of the air layer between the two. For this reason, a certain substance must be filled between the surface of the probe and the skin to drive out the air and form a channel for the smooth and undistorted transmission of ultrasonic waves. This substance is called a medical ultrasonic coupling agent. [0003] Medical ultrasonic couplin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/22A61K36/54A61P31/04A61P31/10A61P31/02A01N65/24A01P3/00A01P1/00A61K31/734
CPCA61K49/22A01N65/00A01N65/24A61K31/734A61K36/54A61K2300/00A01N2300/00
Inventor 董晓蒋玉芳薛蕾
Owner 董晓
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