Preparation method of povidone iodine powder

A technology of povidone iodine and solid powder, which is applied in the field of preparation of povidone iodine, can solve the problems of difficult industrialization, high equipment requirements, and long process routes, and achieve low iodine content, stable quality, and low process equipment requirements Effect

Inactive Publication Date: 2017-05-17
CHANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] It can be seen from the above analysis that the existing methods either have the problem of high free iodine content in the product, or have the problems of high equipment requirements, long process route, unstable product quality, and difficult industrialization.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Add 1.00g of iodine, 4.00g of polyvinylpyrrolidone K30, and 30.0mL of cyclohexane in sequence into a 100mL three-necked flask, stir evenly, heat the oil bath to 70°C, and perform the complexation reaction for 2 hours, then cool and discharge. The solid after suction filtration was air-dried to obtain 4.85 g of reddish-brown powder. Weigh 0.23g of PVP-I powder, add a small amount of ethanol to dissolve, titrate with calibrated 0.1mol / L sodium thiosulfate solution, add starch indicator near the end point, continue titration until the blue color disappears, and the volume of the titration solution is 2.50 mL. The calculated solid PVP-I available iodine content is 13.79%.

Embodiment 2

[0025] Add 1.00g of iodine, 4.00g of polyvinylpyrrolidone K30, and 30.0mL of cyclohexane in sequence into a 100mL three-necked flask, mix well, heat in an oil bath at 60°C, stir and reflux for 4 hours, then cool and discharge. The solid after suction filtration was air-dried to obtain 4.96 g of reddish-brown powder. Weigh 0.28g of PVP-I powder, add a small amount of ethanol to dissolve, titrate with 0.1mol / L sodium thiosulfate solution after calibration, add starch indicator near the end point, continue titration until the blue color disappears, and the volume of titration solution is 3.00 mL. The calculated solid PVP-I available iodine content is 13.60%.

Embodiment 3

[0027] Add 1.00g of iodine, 4.50g of polyvinylpyrrolidone K30, and 20.0mL of xylene into a 100mL three-necked flask in sequence, mix well, heat in an oil bath at 100°C, stir and reflux for 2 hours, cool and discharge, filter, and dry to obtain reddish brown Powder 5.42g. Weigh 0.30g of PVP-I powder, add a small amount of ethanol to dissolve, titrate with 0.1mol / L sodium thiosulfate solution after calibration, add starch indicator near the end point, continue titration until the blue color disappears, and the titration solution volume is 3.02 mL. The calculated solid PVP-I available iodine content is 12.78%.

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PUM

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Abstract

The invention relates to a novel method for preparing povidone iodine solid powder. The method particularly comprises the following steps: in the presence of an organic solvent, complexing a polyvinylpyrrolidone solid and iodine, and carrying out liquid-solid separation to obtain the povidone iodine solid powder. Compared with the existing processes, the method has the advantages of low uncomplex iodine content in the product, stable product quality, and low requirements for technological equipment, and is suitable for industrial production.

Description

technical field [0001] The invention relates to a preparation method of povidone-iodine, in particular to a new method for obtaining povidone-iodine powder by liquid-solid separation after polyvinylpyrrolidone powder and iodine are complexed in a solvent. Background technique [0002] Povidone-iodine is a complex iodine formed by polyvinylpyrrolidone (PVP) and iodine in a complex form with the help of hydrogen bonds. Povidone-iodine, also known as polyvinylpyrrolidone-iodine, iodophor, and Yisujing, can be expressed as PVP-I. It is an internationally recognized high-efficiency, broad-spectrum, and non-toxic fungicide. It has a strong killing effect on Staphylococcus aureus, hepatitis B virus, Neisseria gonorrhoeae, Pseudomonas aeruginosa, Escherichia coli, virus Mycobacterium tuberculosis, etc., and has been included in the Pharmacopoeia of the People's Republic of China. It is widely used in the fields of textile printing and dyeing, medicine, cosmetics, detergents, paints...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F8/22C08F26/10
CPCC08F8/22C08F26/10
Inventor 林富荣顾金艳仲艳艳
Owner CHANGZHOU UNIV
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