Photoacoustic microimaging adaptive scanning system and method

A photoacoustic microscopy and scanning system technology, applied in applications, medical science, diagnosis, etc., can solve problems such as inability to image high-quality materials or biological tissues, and achieve the effect of ensuring real-time focusing and high-resolution imaging

CN106691377AInactive Publication Date: 2017-05-24HARBIN INST OF TECH AT WEIHAI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Publication Date
2017-05-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a photoacoustic microimaging adaptive scanning system and method. The photoacoustic microimaging adaptive scanning system comprises a master control set, a laser, an ultrasonic probe, an infrared ranging device and a drive unit; the infrared ranging device detects first vertical distance between the ultrasonic probe and a first position point of to-be-detected tissue; the infrared ranging device detects second vertical distance between the ultrasonic probe and a second position point of the to-be-detected tissue; the master control set controls the drive unit to drive the ultrasonic probe to move to the position above the second position point according to the first vertical distance and the second vertical distance, and the distance between the ultrasonic probe and the second position point is enabled to be equal to the first vertical distance; the ultrasonic probe collects photoacoustic signals generated from the first position point and the second position point. By the arrangement, the distance between the ultrasonic probe and the to-be-detected tissue can be automatically adjusted when materials or biological tissue lower in flatness are subjected to imaging, real-time focusing is guaranteed, and high-resolution imaging of photoacoustic images is realized.
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Description

technical field

[0001] The invention relates to the technical field of microscopic imaging, in particular to an adaptive scanning system and method for photoacoustic microscopic imaging. Background technique

[0002] Photoacoustic imaging is a non-destructive medical imaging method that has developed rapidly in recent years, combining the high penetration characteristics of pure ultrasound imaging with the high contrast characteristics of pure optical imaging. It uses pulsed laser as the excitation source and photoacoustic signal as the information carrier. According to the principle that different biological tissues have different optical absorption coefficients for specific wavelength lasers and then radiates different intensities of ultrasonic waves, it performs imaging through the collected photoacoustic signals. An imaging method that performs image reconstruction processing to obtain internal structure information of tissues. Photoacoustic imaging technology combines ...

Examples

Embodiment Construction

[0042] Embodiments of the present invention will be described in detail below with reference to the accompanying drawings.

[0043] Such as figure 1 As shown, the embodiment of the present invention provides a photoacoustic microscopy imaging adaptive scanning system, the system includes:

[0044] A main control device 1, a laser 2 connected to the main control device 1, an ultrasonic probe 3, an infrared distance measuring device 4 and a driving device 5, the laser 2 is used to emit a laser beam, and the laser beam passes through an optical fiber bundle 7 in sequence and the objective lens 8 are focused on the surface of the tissue to be measured 10 to generate a photoacoustic signal; the relative positions of the objective lens 8, the ultrasonic probe 3 and the infrared distance measuring device 4 are fixed;

[0045] When the infrared distance measuring device 4 is located above the first position point of the tissue to be measured 10, the infrared distance measuring device...