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Application of glacial acetic acid in freeze-drying process of Panax Notoginseng saponins or composition thereof

A technology of Panax notoginseng saponins and freeze-drying method, which is applied in the field of chemical drugs, can solve the problems of no freezing method and conditions, long turnaround time, and large production energy consumption, and achieve significant economic and social benefits. Freeze-drying The effect of short cycle time and energy saving

Inactive Publication Date: 2017-05-24
GUANGXI WUZHOU PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Chinese patent application 96101652.3 relates to a drug in a special dosage form for the treatment of cardiovascular and cerebrovascular diseases, but does not give specific freezing methods and conditions
[0009] The safety of injections has exposed many problems in recent years. The use of excipients other than drugs in injections will cause patients to have to accept more unnecessary substances into the blood at the same time during treatment, laying the groundwork for adverse reactions. Hidden danger; while in the preparation method, the production is energy-intensive and the turnaround time is long

Method used

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  • Application of glacial acetic acid in freeze-drying process of Panax Notoginseng saponins or composition thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Weigh Panax notoginseng total saponins, operate according to the following steps:

[0032] 1) Pre-freezing: add Panax notoginseng saponins into glacial acetic acid with a water content of 5%, dissolve at 20°C to make a 0.5% solution, filter, and pack the filtrate into open containers, and place in a freeze-drying cabinet. Continue to cool down to 5°C within 0.25h, and maintain this temperature for 0.5h;

[0033] 2) Freezing and system balance: After the pre-freezing is completed, continue to cool down within 0.25 hours, lower the temperature in the freeze-drying cabinet to -5°C, and maintain this temperature for 0.5 hours, and then maintain the same temperature to freeze The pressure in the dry cabinet is adjusted to 2Pa and maintained for 1.5h;

[0034] 3) Sublimation: maintain the vacuum at 2Pa, increase the temperature of the inner plate layer of the freeze-drying cabinet from the base temperature of -5°C to 5°C, and keep it at this temperature for 1.5 hours; then k...

Embodiment 2

[0039] Weigh Panax notoginseng total saponins, operate according to the following steps:

[0040] 1) Pre-freezing: Add Panax notoginseng saponins to glacial acetic acid with a water content of 2%, dissolve at 30°C to make a 5% solution, filter, pack the filtrate into open containers, and place in a freeze-drying cabinet. Continue to cool down to 0°C within 0.5h, and maintain this temperature for 0.75h;

[0041] 2) Freezing and system balance: After the pre-freezing is completed, continue to cool down within 0.5 hours, lower the temperature in the freeze-drying cabinet to -15°C, and maintain this temperature for 0.75 hours, and then maintain the same temperature to freeze The pressure in the dry cabinet is adjusted to 10Pa and maintained for 2h;

[0042]3) Sublimation: maintain the vacuum degree at 10Pa, raise the temperature of the inner plate layer of the freeze-drying cabinet from the base temperature of -15°C to 0°C, and keep it at this temperature for 2 hours; then keep t...

Embodiment 3

[0047] Weigh Panax notoginseng total saponins, operate according to the following steps:

[0048] 1) Pre-freezing: Add Panax notoginseng saponins to anhydrous glacial acetic acid, dissolve at 40°C to make a 20% solution, filter, divide the filtrate into open containers, put it in a freeze-drying cabinet, and keep it for 1 hour Cool down to -5°C, and maintain this temperature for 1h;

[0049] 2) Freezing and system balance: After the pre-freezing is completed, continue to cool down within 1 hour, lower the temperature in the freeze-drying cabinet to -30°C, and maintain it at this temperature for 1 hour, and then keep the temperature constant to cool the freeze-drying cabinet The pressure inside is adjusted to 50Pa and maintained for 3h;

[0050] 3) Sublimation: maintain the vacuum at 50Pa, increase the temperature of the inner plate layer of the freeze-drying cabinet from the base temperature of -30°C to -5°C, and keep it at this temperature for 3 hours; then keep the temperat...

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Abstract

The invention relates to an application of glacial acetic acid in a process for preparing a loose and dry substance from Panax Notoginseng saponins or composition thereof with a non-water freeze-drying method. When freeze-dried Panax Notoginseng saponins or the composition thereof are prepared through drying with a specified freeze-drying process, a freeze-drying preparation method of the Panax Notoginseng saponins or the composition thereof has the characteristic of extremely low moisture content, and the freeze-drying period is short.

Description

technical field [0001] The invention relates to the field of chemical medicines, in particular to the application of glacial acetic acid in the process of making loose dried products of Panax notoginseng saponins or its composition by freeze-drying. Background technique [0002] The freeze-drying time of Panax notoginseng saponins freeze-dried powder injection generally takes more than 30 hours, and the shortest one takes about 20 hours. There is no public literature report on the detailed study on the freeze-drying of Panax notoginseng saponins. The following are some preparation process literatures of Chinese medicine and western medicine freeze-dried powder injection related to freeze-drying technology. [0003] Chinese patent application 96101652.3 relates to a medicine in a special dosage form for treating cardiovascular and cerebrovascular diseases, but does not provide specific freezing methods and conditions. [0004] Chinese patent application 200610010988.5 states...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258F26B5/06
Inventor 黄宇声刘冠萍徐卓张栩颜陈志坚程智宁陈勇贤英越
Owner GUANGXI WUZHOU PHARMA GRP
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