A kind of anti-collapse calcium-silica-based composite bone cement and its preparation method and application
A bone cement and anti-collapse technology, which is applied in the fields of medical formula, prosthesis, and drug delivery, can solve the problems of bone cement blood dispersal, solid-liquid separation, etc., and achieve support for proliferation and differentiation, low cost, and simple preparation methods Effect
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
preparation example Construction
[0033] The preparation method of the anti-collapse calcium-silicon-based composite bone cement of the present invention specifically includes the following steps.
[0034] (1) Sodium alginate solution
[0035] Weigh sodium alginate (SA) powders of different masses, add them into deionized water, and stir at room temperature for 1-5 hours to obtain sodium alginate (SA) solutions with different concentrations. In the present invention, the concentration of the sodium alginate (SA) solution may be 0.1wt%-10wt%, preferably 1wt%-2wt%. When not in use, the sodium alginate solution can be stored in a low-temperature environment for future use, such as in a refrigerator at 4°C.
[0036] (2) Preparation of calcium-silica-based composite bone cement
[0037] Calcium-silica-based bone cement powder and different concentrations of sodium alginate (SA) solutions are fully reconciled at a liquid-solid ratio of 0.4-1.2mL / g for 0.5-1 minute to obtain calcium-silica-based / seaweed with anti-c...
Embodiment 1
[0054] 1) Preparation of sodium alginate solution:
[0055] Weigh 0.2g of sodium alginate powder and dissolve it in 20mL of deionized water, and stir evenly at room temperature to finally obtain a sodium alginate solution with a concentration of 1.0%, and store it in a 4°C refrigerator for later use;
[0056] 2) Preparation of tricalcium silicate / sodium alginate composite bone cement:
[0057] Tricalcium silicate powder and 1.0% sodium alginate solution were uniformly mixed at a liquid-solid ratio of 0.6mL / g to obtain tricalcium silicate / sodium alginate composite bone cement slurry, and the content of sodium alginate was 0.6% at this time . The collapse resistance and injectability of the composite bone cement paste were tested at room temperature. The results show that the composite bone cement paste has obvious anti-collapse effect in water (see image 3 Figure b) in Fig. 1; the injectability of the slurry is close to 100% after standing in the syringe for 5 minutes (see ...
Embodiment 2
[0059] 1) Preparation of sodium alginate solution:
[0060] Weigh 0.3g of sodium alginate powder and dissolve it in 20mL of deionized water, and stir evenly at room temperature to finally obtain a sodium alginate solution with a concentration of 1.5%, and store it in a refrigerator at 4°C for later use;
[0061] 2) Preparation of tricalcium silicate / sodium alginate composite bone cement:
[0062] Tricalcium silicate powder and 1.5% sodium alginate solution were evenly blended at a liquid-solid ratio of 0.6mL / g to obtain a tricalcium silicate / sodium alginate composite bone cement slurry. At this time, the content of sodium alginate was 0.9%. . The collapse resistance and injectability of the composite bone cement paste were tested at room temperature. The results show that the composite bone cement paste has obvious anti-collapse effect in water (see image 3 Panel c) in Fig. 1; the injectability of the slurry is close to 100% after standing in the syringe for 5 minutes (see ...
PUM
| Property | Measurement | Unit |
|---|---|---|
| particle diameter | aaaaa | aaaaa |
| compressive strength | aaaaa | aaaaa |
| compressive strength | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
Login to View More