Oral disintegrating tablet and preparation method thereof

An oral disintegrating tablet and a disintegrating agent technology are applied in the field of oral disintegrating tablet and its preparation, which can solve the problems of inability to obtain satisfactory results, incapable of frequent use, inconvenience to carry, etc. The effect of holding and carrying, inhibiting bacterial growth

Active Publication Date: 2017-05-31
YUNNAN BAIYAO GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Slight bad breath is not easy to be noticed, but image points are often deducted unknowingly; heavy bad breath will cause obvious delay and seriously affect social interaction
Although products such as chewing gum and mouth spray can

Method used

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  • Oral disintegrating tablet and preparation method thereof
  • Oral disintegrating tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] The weight of each orally disintegrating tablet is 1g, and raw materials are prepared: accurately weigh 0.3g of freshener and 0.7g of disintegrating agent.

[0045] The following defines the weight of the components of the freshener and the mass percentage of each component in the freshener. Wherein, what is in brackets is the mass percentage of each component in the freshener. Subsequent embodiments are the same and will not be repeated here. The refreshing agent includes 0.105g (35%) of Lactobacillus paracasei, 0.09g (30%) of Yunnan Baiyao extract and 0.105g (35%) of essence.

[0046] Next, the weight of the components of the disintegrant and the mass percentage of each component in the disintegrant are defined. Among them, the brackets are the mass percentage of each component in the disintegrant. Subsequent embodiments are the same and will not be repeated here. Disintegrants include microcrystalline cellulose 0.07 (10%), crospovidone 0.035 (5%), sodium bicarbon...

Embodiment 2

[0049] The weight of each orally disintegrating tablet is 1g, and raw materials are prepared: accurately weigh 0.3g of freshener and 0.7g of disintegrating agent.

[0050] The following defines the weight of the components of the freshener and the mass percentage of each component in the freshener. The refreshing agent includes 0.135g (45%) of Lactobacillus paracasei, 0.03g (10%) of Yunnan Baiyao extract and 0.135g (45%) of essence.

[0051] Next, the weight of the components of the disintegrant and the mass percentage of each component in the disintegrant are defined. Disintegrants include microcrystalline cellulose 0.14g (20%), crospovidone 0.105g (15%), sodium bicarbonate 0.175g (25%), citric acid 0.105g (15%), sugar alcohol 0.175g (25%).

[0052] The preparation method of the orally disintegrating tablet: the freshener and the disintegrant were dried at 65° C. for 20 hours. The measured mass percent of the water content of the disintegrant and freshener is 0.1%. Then t...

Embodiment 3

[0054] The weight of each orally disintegrating tablet is 1g, and raw materials are prepared: accurately weigh 0.2g of freshener and 0.8g of disintegrating agent.

[0055] The following defines the weight of the components of the freshener and the mass percentage of each component in the freshener. Refreshing agents include Lactobacillus paracasei 0.074g (37%), Yunnan Baiyao extract 0.03g (15%), essence 0.078g (39%), allantoin 0.004g (2%), zinc L-lactate 0.004g (2%) %), chlorophyll powder 0.01g (5%).

[0056] Next, the weight of the components of the disintegrant and the mass percentage of each component in the disintegrant are defined. Disintegrants include microcrystalline cellulose 0.024g (3%), crospovidone 0.12g (15%), sodium bicarbonate 0.24g (30%), citric acid 0.096g (12%), sugar alcohol 0.32g (40%).

[0057] The preparation method of the orally disintegrating tablet: the freshener and the disintegrating agent were dried at 60° C. for 22 hours. The measured mass perc...

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Abstract

The invention provides an oral disintegrating tablet and a preparation method thereof, and belongs to the field of oral cleaning articles. The oral disintegrating tablet is prepared from the following raw materials in percentage by mass: 50 to 80% of disintegrating agent and 20 to 50% of refreshing agent, wherein the refreshing agent is prepared from the following components in percentage by mass: 10 to 45% of lactobacillus paracasei, 10 to 35% of Yunnan Baiyao extract and 20 to 55% of essence. The oral disintegrating tablet has the advantages that by adopting the design, the carrying is convenient; the oral disintegrating tablet can be quickly disintegrated in an oral cavity, the refreshing agent is quickly distributed in the oral cavity, and the purpose of gargling is realized. The preparation method of the oral disintegrating tablet is simple, and comprises the following steps of drying the raw materials, uniformly mixing, and pressing into a tablet at the pressure of 3 to 5kg.

Description

technical field [0001] The invention relates to the field of oral cleaning products, in particular to an orally disintegrating tablet and a preparation method thereof. Background technique [0002] Bad breath can have a negative impact on people's social interactions. Slight bad breath is not easy to detect, but image points are often deducted unknowingly; heavy bad breath will cause people to have a significant sense of delay and seriously affect social interaction. Although products such as chewing gum and mouth spray can cover up bad breath, they often cannot obtain satisfactory results. The best way is to brush your teeth and rinse your mouth with mouthwash, but toothpaste and ordinary mouthwash are inconvenient to carry and cannot be used frequently. Contents of the invention [0003] The purpose of the present invention is to provide an orally disintegrating tablet. The design of the tablet is easy to carry, and at the same time, the orally disintegrating tablet ca...

Claims

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Application Information

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IPC IPC(8): A61K8/99A61K8/97A61K8/02A61K8/81A61K8/73A61K8/58A61K8/49A61K8/365A61K8/34A61K8/19A61K36/00A61K9/20A61Q11/00A61P1/02A61K35/747A61K31/4166A61K31/19A61K31/409
CPCA61K8/0204A61K8/19A61K8/345A61K8/365A61K8/4946A61K8/58A61K8/585A61K8/731A61K8/8176A61K8/97A61K8/99A61K9/0056A61K9/2054A61K31/19A61K31/409A61K31/4166A61K35/747A61K36/00A61Q11/00A61K2300/00
Inventor 李劲峰宁科功伍鹏张秋霞刘萍张浩
Owner YUNNAN BAIYAO GROUP
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