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Manufacture method for soluble microneedle

A manufacturing method and soluble technology, which can be applied in the direction of microneedles, skin care preparations, medical preparations with non-active ingredients, etc., and can solve problems such as limiting the application of soluble microneedles

Inactive Publication Date: 2017-05-31
YOUWE ZHUHAI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the centrifugal force or vacuum treatment process applied to the microneedle mold 10 in the existing manufacturing method and the need to repeat the process, the instability of each batch of microneedle production limits its application in the industrialization of soluble microneedles. Applications

Method used

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  • Manufacture method for soluble microneedle
  • Manufacture method for soluble microneedle
  • Manufacture method for soluble microneedle

Examples

Experimental program
Comparison scheme
Effect test

no. 1 example

[0041] see figure 2 , in the microneedle manufacturing method of the present embodiment, the mold of the microneedle is first produced, the microneedle mold 20 has a plurality of micropore cavities 21, and each micropore cavity 21 is an inverted cone shape, of course, the shape of the micropore cavity It is not limited to the inverted tapered shape, and other shapes are also possible. Preferably, the height of each microneedle cavity 21 is between 50 microns and 1000 microns, and the inner diameter at the mouth of each microneedle cavity 21 is less than 1000 microns.

[0042] The microneedle mold 20 can be prepared using a wet etching process, for example, the pyramidal silicon microneedles are arranged in a 10×10 array, the length of the microneedle array is 200 microns, and the base diameter is 100 microns, or the cones The silicon microneedles are arranged in a 20×20 array. The length of the microneedle array is 800 microns, and the base diameter is 300 microns. needle c...

no. 2 example

[0049] see image 3 , using this embodiment to manufacture microneedles, firstly manufacture a microneedle mold 30, and the microneedle mold 30 has a plurality of microporous cavities 31 therein. After manufacturing the microneedle mold 30, at first spray water or the active drug solution into the microneedle mold 30, that is, use the high-pressure atomization nozzle 35 of the high-pressure atomization device to spray water or the active drug solution to the microneedle mold 30, as in this embodiment The high-pressure atomizing nozzle 35 sprays water 32 to the microneedle mould. Since the viscosity of water is very low and the surface tension is very small, it can easily flow into the microporous cavity 31 .

[0050] Then, the polymer solution 33 is sprayed to the microneedle mold 30 by using a high-pressure atomizing device. Since the microporous cavity 31 has been filled with water, the polymer solution 33 is actually sprayed on the water 32 . Moreover, since the polymer s...

no. 3 example

[0052] Such as Figure 4 As shown, a microneedle mold 40 is manufactured first, and a plurality of micropore cavities 41 are arranged in the microneedle mold 40 . Then, the surfactant 42 is sprayed into the microporous cavity 41 using a high-pressure atomizing device. Since the viscosity of the surfactant 42 used in this embodiment is low, and the amount injected into the microneedle mold 40 is less, the surfactant 42 only adheres to the inner wall of the micropore cavity 41 and does not fill the microneedle mold 40. Each microporous cavity 41 is filled, thereby forming a filling space 47 in the surfactant 42 .

[0053] Then, use the high-pressure atomizing nozzle 45 of the high-pressure atomizing equipment to spray the atomized polymer solution 43 on the microneedle mold 40, because the surfactant 42 has hydrophilicity, and the polymer solution 43 and the surfactant It has mutual solubility, so the polymer solution 43 can be evenly mixed on the surfactant 42, and each micro...

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Abstract

The invention provides a manufacture method for a soluble microneedle. The manufacture method comprises the following steps: manufacturing a microneedle mould, wherein the microneedle mould is provided with a plurality of micropore cavities; in addition, using high-pressure spraying equipment to inject macromolecular solution to the micropore cavities; filling the macromolecular solution into each micropore cavity; after the macromolecular solution is dried, taking out a solidified microneedle from the microneedle mould. Optimally, a high-pressure atomizing unit is used for injecting atomized macromolecular solution to the micropore cavities, or high-pressure burst firing equipment is used for injecting the drops of the macromolecular solution to the micropore cavities. When the method disclosed by the invention is applied to manufacture the microneedle, ways including vacuumizing, centrifugal force loading and the like are not required, the manufacture technology of the microneedle is simple, and a superior rate for microneedle manufacture can be improved.

Description

technical field [0001] The invention relates to the field of medical equipment, in particular to a method for manufacturing a soluble microneedle. Background technique [0002] The use of soluble microneedles as a new painless transdermal drug delivery technology can painlessly create micron-scale drug delivery channels on the skin and enhance the skin's permeability to active substances or drugs, especially macromolecular drugs. Due to the painless, safe, and easy-to-operate advantages of soluble microneedle drug delivery technology, it is the development direction of transdermal drug delivery to the body in the future. [0003] The height of the microneedles used in microneedle drug delivery technology is generally between 50 microns and 1000 microns, which can penetrate the stratum corneum of the skin with natural protection (usually only 10 microns to 20 microns), but it does not reach the level of nerve endings. It is deep in the skin and will not cause pain. It is sui...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K47/36A61K8/02A61K8/73A61Q19/00A61M37/00
CPCA61K8/02A61K8/735A61K9/0021A61K47/36A61K2800/10A61M37/0015A61M2037/0053A61Q19/00A61M2037/0046B29C39/025B29C39/10B29C39/24B29C41/08B29C41/36B29L2031/756B29L2031/759A61M2037/0023A61M2207/10B29C41/10B29K2105/0035B29K2105/0058B29K2995/006B29L2031/7544
Inventor 李成国
Owner YOUWE ZHUHAI BIOTECH CO LTD
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