Method for preparing Gengnian An tablets

Abstract

The invention relates to a method for preparing Gengnian An tablets. The method comprises the following steps: (1), preparation of backflow paste: taking caulis polygoni multiflori, radix polygonum multiflorum preparata, ramulus uncariae cum uncis, schisandra chinensis, rhizoma alismatis and cortex moutan, adding 4-8 times amount of 60% ethyl alcohol, performing reflux extraction for 1-3 times (1-3 h for each time), and performing concentration to obtain the backflow paste; (2), preparation of a dry extract powder: taking rhizoma rehmanniae, radix scrophulariae, poria cocos, radix rehmanniae praeparata, rhizoma curculiginis and radix ophiopogonis, adding 4-8 times amount of water, performing decoction for 1-3 times (1-3 h for each time), concentrating the decoction solution into thick paste, performing drying under reduced pressure, and conducting crushing to obtain the dry extract powder; (3), preparation of three herbal powder including fructus tritici levis: weighing and drying fructus tritici levis, magnetitum and concha margaritiferallsta, performing crushing into powder, and respectively bagging the powder for later use; (4), uniformly mixing powder of the three herbs including fructus tritici levis, the dry extract powder and the backflow paste, and performing granulation, drying and tabletting to obtain the tablets.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a preparation method of Gengnian'an tablets. Background technique [0002] The prescription of Gengnian'an Tablets is composed of fifteen Chinese medicinal materials. The current preparation process: the three medicinal materials of floating wheat, magnetite, and mother-of-pearl powder are crushed into fine powder; The medicinal materials are decocted with water to obtain a decoction concentrated solution; the other six medicinal materials of Radix Polygoni Multiflori, Radix Polygoni Multiflori, Uncaria, Schisandra, Alisma, and Cortex Moutan are extracted by percolation with 60% ethanol to obtain a concentrated solution of percolation; take the above two The concentrated liquid is mixed with three-flavored fine powder such as floating wheat, and made into coarse granules, dried, crushed, sieved, added with an appropriate amount of 75% ethanol to make granules, dried ...

AI Technical Summary

Problems solved by technology

[0004] The Gengnian’an tablet prepared by the prior art mainly has the problem of low extraction and transfer rate of emodin, the active ingredient of Radix Polygoni Multiflori and Shouwu Teng, and the low friability of the plain tablet, which leads to a little edge falling during coating. The process is complex, because of the large amount of clear paste, it needs to be granulated twice to make Gengnianan tablets. The two drying processes have a certain loss on the emodin content of the granules and the identification of Schisandra chinensis.

[0005] The inventors have found through research that the above-mentioned preparation method has problems such as low drug efficacy and waste of medicinal materials, and the resulting tablet will split when stored for a certain period of time, and the active ingredient will be reduced

For this reason, the applicant improves the existing preparation method, and provides a new preparation method of Gengnian'an Tablet, which can improve the curative effect of Gengnian'an Tablet, increase the active ingredient content of Gengnian'an Tablet, and solve the Stability and Fragmentation Issues

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