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Levamisole hydrochloride medicinal composition

A technology of levamisole hydrochloride and composition, which is applied in the field of levamisole hydrochloride pharmaceutical composition and preparation thereof, can solve the problems of inability to persist in long-term medication and affect the curative effect, and achieve the effects of significant curative effect and small side effects

Inactive Publication Date: 2017-06-13
KAMP PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Yet existing levamisole hydrochloride preparation product only has a kind of oral tablet, and the side reaction rate of oral administration is generally about 30%, mainly are the gastrointestinal reactions such as nausea, vomiting, gastrointestinal discomfort, abdominal pain and dizziness, headache etc.
Therefore, long-term medication cannot be adhered to, thereby affecting the curative effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Prescription: (makes 1000 tablets)

[0022] Main ingredient: Levamisole Hydrochloride 50g

[0023] Accessory material: starch 62g

[0024] Dextrin 20g

[0025] Magnesium stearate 1.24g

[0026] Preparation:

[0027] 1) Weigh levamisole hydrochloride, starch, and dextrin according to the prescription, mix well, pass through 40 and 60 mesh sieves once, and mix well;

[0028] 2) Put the mixture in the mixing tank, dry stir, add 10% starch slurry, stir for 15-20 minutes to make a suitable soft material, granulate with a 16-mesh nylon sieve, dry at a temperature of 55-60°C, dry Grain moisture should be controlled below 3.0%;

[0029] 3) Add magnesium stearate to the dry granules, mix well; sieve the granules with 18-mesh nylon sieve, mix well, and press into tablets with a 5.5mm shallow concave die.

Embodiment 2

[0031] Prescription: (makes 1000 tablets)

[0032] Main ingredient: Levamisole Hydrochloride 50g

[0033] Accessories: starch 64g

[0034] Dextrin 18g

[0035] Magnesium stearate 1.24g

[0036] Preparation:

[0037] 1) Weigh levamisole hydrochloride, starch, and dextrin according to the prescription, mix well, pass through 60 and 80 mesh sieves once, and mix well;

[0038] 2) Put the mixture in the mixing tank, dry stir, add 10% starch slurry, stir for 15-20 minutes to make a suitable soft material, granulate with 18-mesh nylon sieve, dry at 55-60°C, dry Grain moisture should be controlled below 3.0%;

[0039] 3) Add magnesium stearate to the dry granules, and mix well; sieve the granules with a 20-mesh nylon sieve, mix well, and press into tablets with a 5.5mm shallow concave die.

[0040] Example 1

[0041] Prescription: (makes 1000 tablets)

[0042] Main ingredient: Levamisole Hydrochloride 50g

[0043] Accessories: starch 60g

[0044] Dextrin 22g

[0045] Magnes...

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PUM

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Abstract

The invention discloses a levamisole hydrochloride pharmaceutical composition, which is characterized in that the pharmaceutical composition is composed of levamisole hydrochloride and pharmaceutical auxiliary materials. The pharmaceutical composition is an oral preparation, and the percentage by weight of the prescription is: 5-55% of levamisole hydrochloride and 45-95% of pharmaceutical auxiliary materials. The prescription pharmaceutical composition of the preparation is used in combination with omeprazole enteric-coated capsules, thereby reducing the incidence of side effects of levamisole hydrochloride.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a levamisole hydrochloride pharmaceutical composition and a preparation method thereof. Background technique [0002] The pharmacological basis of levamisole hydrochloride is that it has no effect on the body with normal immune function, but only exerts a significant enhancement effect on the cases with low immune function, so that it can return to normal. It mainly acts on T lymphocytes, induces the differentiation and maturation of early pre-T cells into functional T cells, and restores dysfunctional T cells to normal. At the same time, it can enhance the chemotaxis and phagocytosis of monocytes, activate macrophages and granulocytes Inhibiting factor of cell movement, induces endogenous interferon, thus produces immune function and antiviral efficacy. Moreover, the metabolite of levamisole hydrochloride, omediazole (OMPI), has a stronger immunoregulatory...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/429A61K31/4439A61K47/36A61K47/12A61P37/02
CPCA61K9/2059A61K9/2077A61K31/429A61K31/4439
Inventor 曾培安吴健民贺莲
Owner KAMP PHARMA
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