A superfast nuclear magnetic resonance two-dimension J spectrum method resisting a nonuniform magnetic field

Abstract

A method of acquiring a nuclear magnetic resonance two-dimension J spectrum in a superfast manner through single scanning resisting a unidirectional nonuniform magnetic field environment is provided. By utilization cooperation of a selective excitation module and a reunion sampling module, limits of traditional two-dimension J spectrum methods are broken, a two-dimension J spectrum can be acquired by superfast sampling in the unidirectional nonuniform magnetic field environment, influences of unidirectional magnetic field nonuniformity are effectively eliminated, experiment time is greatly shortened, and the application field of the two-dimension J spectrum is broadened. The method is suitable for conventional nuclear magnetic resonance spectrometers, does not need any special hardware apparatus, does not need any special sample pretreatment process, is simple, convenient and feasible, and provides an important means for rapidly acquiring a two-dimension J spectrum of a complex organic sample.

Description

technical field [0001] The invention relates to nuclear magnetic resonance (Nuclear Magnetic Resonance, NMR) spectroscopy molecular structure information detection technology, in particular to a single-scan ultra-fast acquisition of high-resolution two-dimensional J-spectrum in a single-direction non-uniform magnetic field environment. Background technique [0002] Due to the unique advantages of non-destructive and non-invasive detection of NMR spectroscopy, NMR technology has been widely used in biology, chemistry, physics, medicine, materials science and other disciplines in recent decades. In 1971, scholar Jeener proposed the concept of two-dimensional spectrum on the basis of one-dimensional spectrum, extending NMR from one-dimensional spectrum to two-dimensional spectrum. In conventional nuclear magnetic resonance spectroscopy detection, two-dimensional spectroscopy overcomes the problems of spectral crowding and peak assignment difficulties that often exist in one-dim...

AI Technical Summary

Problems solved by technology

Although the traditional two-dimensional J spectrum method provides a general method for obtaining nuclear chemical shift and coupling information, in practical applications, this technique has some limitations.

First of all, the traditional two-dimensional J spectrum method requires two-dimensional sampling, which takes a long time under the premise of ensuring the resolution of the spectrum

This problem limits the application of this method in real-time monitoring of chemical reactions and other fields, and also limits the development and application of this method to multidimensional spectroscopy.

Secondly, the acquisition of the traditional two-dimensional J-spectrum is limited by the uniformity of the magnetic field, and an ideal two-dimensional J-spectrum needs to be obtained under a relatively uniform magnetic field.

In practical applications, for homogeneous solution sample systems, it is necessary to perform complex and time-consuming shimming operations on the detection samples to obtain an ideal magnetic field environment; while for heterogeneous samples such as viscous samples and biological tissue samples , the magnetic susceptibility of the sample itself will bring large inhomogeneity of the magnetic field, and it is often difficult or even impossible to obtain a sufficiently high magnetic field uniformity

This problem also limits the scope of application of the traditional J-spectrum method

Images