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A resveratrol self-microemulsion preparation and a preparing method thereof

A technology of resveratrol and emulsion preparation, applied in the field of biochemical separation and purification, can solve the problems of fast metabolism and elimination rate, poor stability, difficult resveratrol and the like

Inactive Publication Date: 2017-06-23
CHONGQING DOUHAO BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the characteristics of resveratrol insoluble in water, poor stability, low bioavailability, short half-life, fast metabolism and elimination rate, its clinical application is greatly limited.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] (1) Weigh 1g of triacetin, 1.5g of Cremophor EL, 0.5g of Cremophor RH40, and 1.5g of isopropanol, and mix them evenly in a 37°C water bath with magnetic stirring.

[0018] (2) Add 0.4 g of resveratrol crude drug, and mix evenly in a water bath at 37° C. under the action of magnetic stirring to obtain a resveratrol self-microemulsion preparation.

Embodiment 2

[0020] (1) Weigh 1 g of glycerol triacetate, 1 g of Cremophor EL, 0.7 g of Cremophor RH40, and 2.0 g of isopropanol, and mix them evenly in a 37°C water bath with magnetic stirring.

[0021] (2) Add 0.4 g of the resveratrol crude drug, and mix evenly in a water bath at 37° C. under the action of magnetic stirring to obtain a resveratrol self-microemulsion preparation.

Embodiment 3

[0023] (1) Weigh 1 g of glycerol triacetate, 1.25 g of Cremophor EL, 0.6 g of Cremophor RH40, and 1.75 g of isopropanol, and mix them evenly in a 37°C water bath with magnetic stirring. .

[0024] (2) Add 0.4 g of the resveratrol crude drug, and mix evenly in a water bath at 37° C. under the action of magnetic stirring to obtain a resveratrol self-microemulsion preparation.

[0025] Example 3 Identification of resveratrol self-microemulsion

[0026] The formation of resveratrol self-microemulsion was verified by transmission electron microscope and particle size detection method.

[0027] The resveratrol self-microemulsion was verified by transmission electron microscope and particle size detection method. The results of transmission electron microscopy showed that the formed nanoemulsion droplets were round in appearance and uniform in size, with a particle size of about 15nm. The particle size was detected by a Malvern particle size analyzer, and the result showed that th...

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Abstract

A resveratrol self-microemulsion preparation is disclosed. The preparation includes glyceryl triacetate that is adopted as an oil phase, polyoxyethylene castor oil (Cremophor EL), polyoxyethylene hydrogenated castor oil (Cremophor RH40) and isopropanol. The mass ratio of the glyceryl triacetate, the Cremophor EL, the Cremophor RH40 and the isopropanol is 1:1-1.5:0.5-0.7:1.5-2.0. The preparation is prepared by fully mixing the glyceryl triacetate, the Cremophor EL, the Cremophor RH40 and the isopropanol under stirring in a water bath having a temperature of (37+ / -2) DEG C. The preparation can be prepared into microemulsion and soft capsules, or can be adopted as an adhesive and prepared into granules, tablets, micro-pills, and other dosage forms.

Description

technical field [0001] The invention belongs to the technical field of biochemical separation and purification, and specifically relates to a resveratrol self-microemulsion preparation and a preparation method thereof. Background technique [0002] Resveratrol (Res) is a non-flavonoid polyphenolic compound containing a stilbene structure, which exists in large quantities in grapes, peanuts and other foods that people often eat. Resveratrol plays an important role in maintaining human health, and has anti-inflammatory, anti-cancer, antibacterial, anti-oxidation and cardiovascular protection effects. Due to the characteristics of resveratrol insoluble in water, poor stability, low bioavailability, short half-life, fast metabolism and elimination rate, its clinical application is greatly limited. According to the hydrophobicity of resveratrol, the present invention is made into a self-microemulsion preparation, aiming at significantly improving the water solubility, stability ...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/05A61K47/14A61K47/44A61K47/10A61P29/00A61P35/00A61P31/04A61P39/06A61P9/00
Inventor 邓小玲其他发明人请求不公开姓名
Owner CHONGQING DOUHAO BIOTECH
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