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Chitosan quaternary ammonium salt multi-sterilization-system contact lens care solution

A quaternary ammonium salt chitosan, contact lens technology, applied in biocides, preservation of human or animal bodies, plant growth regulators, etc. Good compatibility and high biocompatibility

Inactive Publication Date: 2017-07-07
HAICHANG CONTACT LENSES +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the compatibility between fungicides has a great influence on the bactericidal effect, and there is no research on the compounding of quaternary ammonium chitosan and other common fungicides.

Method used

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  • Chitosan quaternary ammonium salt multi-sterilization-system contact lens care solution
  • Chitosan quaternary ammonium salt multi-sterilization-system contact lens care solution
  • Chitosan quaternary ammonium salt multi-sterilization-system contact lens care solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The formulation composition of quaternary ammonium chitosan multi-bactericidal system contact lens care solution is as follows by the mass percentage of care solution (the degree of substitution of quaternary ammonium chitosan used is 80%, molecular weight 600kDa):

[0016]

[0017]

[0018] The balance is other components of the nursing solution and water for injection.

[0019] Suspension quantitative sterilization test shows that the bactericidal rate to Pseudomonas aeruginosa is 99.98%, the bactericidal rate to Staphylococcus aureus is 99.99%, the bactericidal rate to Candida albicans is 98.25%, the cell proliferation rate is 114.5%, and there is no cytotoxicity The contact angle on the silicone hydrogel was 20.0°.

Embodiment 2

[0021] The formula composition of quaternary ammonium chitosan multi-bactericidal system contact lens care solution is as follows (the degree of substitution of quaternary ammonium chitosan used is 84.8%, molecular weight 400kDa):

[0022]

[0023] The balance is other components of the nursing solution and water for injection.

[0024] Suspension quantitative sterilizing test shows that the bactericidal rate to Pseudomonas aeruginosa is 99.91%, the bactericidal rate to Staphylococcus aureus is 99.92%, the bactericidal rate to Candida albicans is 94.26%, the cell proliferation rate is 118.8%, and there is no cytotoxicity . The contact angle on the silicone hydrogel was 40.0°.

Embodiment 3

[0026] The formula composition of quaternary ammonium chitosan multi-bactericidal system contact lens care solution is as follows (the degree of substitution of quaternary ammonium chitosan used is 75.0%, molecular weight 800kDa):

[0027]

[0028] The balance is other components of the nursing solution and water for injection.

[0029] Suspension quantitative sterilization test shows that the bactericidal rate against Pseudomonas aeruginosa is 99.96%, the bactericidal rate against Staphylococcus aureus is 99.93%, the bactericidal rate against Candida albicans is 98.98%, the cell proliferation rate is 107.9%, and there is no cytotoxicity , and the contact angle on the silica hydrogel was 33.5°.

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Abstract

The invention discloses a chitosan quaternary ammonium salt multi-sterilization-system contact lens care solution, which is prepared from sterilization agents, moisture preservation agents, cleaning agents, buffer agents, osmotic pressure regulating agents and chelating agents, wherein the sterilization agents comprise chitosan quaternary ammonium salt and one or a mixture of several kinds of materials selected from poly-quaternary ammonium salt, polyhexamethylene biguanidine hydrochloride, polyaminopropyl biguanide and myristoyl propyl dimethylamine. The chitosan quaternary ammonium salt multi-sterilization-system contact lens care solution has the advantages that the content of each sterilization agent can be reduced through a multi-sterilization-agent system; the cooperated and matching effect between the sterilization agents can be sufficiently utilized; good sterilization performance and biocompatibility can be ensured; the duplex effects of sterilization and moisture preservation are achieved.

Description

technical field [0001] The invention relates to a contact lens care solution, in particular to a quaternary ammonium chitosan multi-sterilization system contact lens care solution. Background technique [0002] As a chitosan derivative, quaternized chitosan not only has good moisture absorption and moisturizing properties, bactericidal properties, film-forming properties, non-toxicity and biocompatibility, but also has many excellent properties of chitosan, and also has typical quaternary ammonium The nature of salt shows stronger bactericidal and antibacterial properties and better moisture absorption and moisturizing properties. The quaternary ammonium chitosan with different molecular weight and different degrees of substitution has different bactericidal and mold-forming properties. In addition, the compatibility of fungicides has a great influence on the bactericidal effect, and there is no research on the compounding of quaternary ammonium chitosan and other common fu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N47/44A01N43/16A01N33/12A01P1/00C11D1/722C11D3/60C11D3/37C11D3/22C11D3/33C11D3/32C11D3/075C11D3/04
CPCA01N47/44A01N33/12A01N37/20A01N43/16C11D1/722C11D3/046C11D3/075C11D3/227C11D3/32C11D3/33C11D3/3703C11D3/3723A01N2300/00
Inventor 束伟霞王怡红王华甫郭庆陈平
Owner HAICHANG CONTACT LENSES
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