Extraction method for effective components of traditional Chinese medicine

The technology of an active ingredient and an extraction method is applied in the field of extraction of active ingredients of traditional Chinese medicinal materials, which can solve the problems of low extraction rate, poor absorption effect of flavonoid glycosides, and low safety, and achieves improvement of extraction rate, retention of safety, and improvement of absorption efficiency. Effect

Inactive Publication Date: 2017-07-14
HENAN KANGHUA PHARMA
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Problems solved by technology

In the prior art, the extraction method of effective components in Chinese medicinal materials is mostly extracted by decocting, and the extraction effect on flavonoid glycosides is better, but the extraction rate for free flavonoids is very low, and although the extraction rate is high when using organic solvent extraction, but low security
On the other hand, the body's absorption effect on flavonoid glycosides is poor, and free flavonoids can be directly absorbed

Method used

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Effect test

Embodiment 1

[0016] A method for extracting effective components of Chinese medicinal materials, characterized in that it comprises the following steps:

[0017] 1) Add enough water to soak the Chinese medicinal materials, add maltose and glycoside synthase at the same time, and keep the temperature at 40~50°C;

[0018] 2) The soaked Chinese medicinal materials are decocted to obtain an aqueous solution;

[0019] 3) Add glycoside hydrolase after the aqueous solution is cooled, and carry out hydrolysis reaction at 40-50°C to obtain a hydrolysis solution;

[0020] 4) The hydrolyzed solution is filtered, concentrated and dried under reduced pressure to obtain the traditional Chinese medicine extract.

[0021] The glycoside synthase described in step 1) is obtained by substituting a non-nucleophile amino acid for a nucleophile amino acid by a glycoside hydrolase.

[0022] The glycoside hydrolase described in step 3) is a mixture of cellulase and pectinase.

[0023] The Chinese herbal medici...

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Abstract

The invention relates to an extraction method for effective components of traditional Chinese medicine. The extraction method for effective components of the traditional Chinese medicine comprises the following steps: 1) adding the traditional Chinese medicine into sufficient water for soaking, adding maltose and glycoside synthetase at the same time in a soaking process and keeping the temperature at 40 to 50 DEG C, wherein the traditional Chinese medicine comprises fructus crataegi, semen raphani, semen cassiae, dried tangerine or orange peel and herba lycopi; 2) decocting the soaked traditional Chinese medicine to get aqueous solution; 3) adding the glycoside synthetase to the aqueous solution after cooling, and conducting hydrolysis reaction at 40 to 50 DEG C to obtain hydrolysis solution; 4) filtering, concentrating and drying the hydrolysis solution under reduced pressure to get traditional Chinese medicine extract. The extraction method for effective components of the traditional Chinese medicine can improve the extraction rate of flavone in the traditional Chinese medicine by a water extraction method.

Description

technical field [0001] The invention relates to a method for extracting effective components of Chinese medicinal materials, belonging to the technical field of health care products. Background technique [0002] Flavonoids are a large class of natural compounds, which widely exist in the plant kingdom and are the active ingredients of many Chinese herbal medicines. Most of them combine with sugar in plants to form flavonoid glycosides, and some exist in a free state. The physiological activity of flavonoids is strong. And Guang, some can lower blood lipids, some have a strong hepatoprotective effect, and some also have anti-inflammatory and crown-expanding effects. Flavonoid glycosides are easily soluble in hot water, while free flavonoids are generally insoluble or insoluble in water. In the prior art, the extraction method of effective components in Chinese medicinal materials mostly adopts the method of decocting to extract, and the extraction effect on flavonoid glycos...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/734A61K36/31A61K36/482A61K36/752A61K36/53
CPCA61K36/31A61K36/482A61K36/53A61K36/734A61K36/752A61K2236/19A61K2236/331A61K2236/51A61K2236/53
Inventor 田国庆王许周赵大庆薛寸艳刘修申
Owner HENAN KANGHUA PHARMA
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